Abstract: Objective　To investigate the clinical characteristics of acute ischemic stroke patients with family history.Methods　Data was derived from the China National Stroke Registry（CNSR）study.A total of 11 031 patients who had acute ischemic stroke with available information of family history from April to May 2018 were included in this study.They were divided into the group with family history（1 406 cases）and group without family history（9 625 cases）.The baseline data and clinical characteristics were collected and compared.Results　The group with family history had lower proportion of female patients and smoking rate and younger age than group without family history（P<0.05）.Systolic pressure，diastolic pressure，drinking rate，incidence rates of ischemic stroke，cerebral hemorrhage，subarachnoid hemorrhage，diabetes，hypertension，asthma，arthritis，wake-up stokes，and headache，National Institutes of Health Stroke Scale（NIHSS）score，incidence rates of upper limb weakness，numbness of limbs，facial paralysis，dysarthria，diplopia and dysphagia in group with family history were significantly higher than those in group without family history（P<0.05）.Conclusion　Acute ischemic stroke patients with family history had more cardiovascular risk factors and neurological deficits were more common in them.

Key words: Stroke, Family history, Clinical characteristic

摘要： 目的　分析有脑卒中家族史急性缺血性脑卒中患者的临床特征。方法　2018年4—5月从中国国家卒中登记研究（CNSR）数据中选取11 031例急性缺血性脑卒中患者的临床资料。根据家族史情况，将患者分为有家族史组（1 406例）和无家族史组（9 625例）。收集并比较两组患者基线资料、临床特征。结果　有家族史组患者女性所占比例、年龄、吸烟率低于无家族史组，收缩压、舒张压、饮酒率、缺血性脑卒中发生率、脑出血发生率、蛛网膜下腔出血发生率、糖尿病发生率、高血压发生率、哮喘发生率、关节炎发生率、醒后脑卒中发生率、头痛发生率、美国国立卫生研究院卒中量表（NIHSS）评分、上肢无力发生率、肢体麻木发生率、面瘫发生率、构音障碍发生率、复视发生率、吞咽困难发生率高于无家族史组（P<0.05）。结论　有家族史急性缺血性脑卒中患者合并心脑血管疾病危险因素较无家庭史患者更多，且神经功能缺损更为常见。

关键词: 卒中, 家族史, 临床特征