Abstract: Objective　To investigate sexual dysfunction status of Chinese female patients with systemic lupus erythematosus（SLE） and its influencing factors.Methods　Eighty female SLE patients from Affiliated Hospital of Nantong University from October 2014 and October 2015 were enrolled to conduct questionnaire investigation.The questionnaires included General Information Questionnaire,Female Sexual Function Index（FSFI） in Chinese Version,Systemic Lupus Erythematosus Disease Activity Index（SLEDAI）,and 36-item Short-Form Health Survey Questionnaire（SF-36） in Chinese version.A total of 85 questionnaires were sent out and 80 were recovered with a response rate of 94.1%.Results　There were 61 patients（76.2%） with sexual dysfunction,including 58（72.5%） loss of libido and 54（67.5%） had difficulties in sexual arousal.The FSFI total scores of patients were correlated with age,years of marriage,age at menarche,menopause or not,combining with heart disease,taking nonsteroidal antiinflammatory drugs,presence of vasculitis and pyuria,dimensional scores of physical function,physical role function and emotional function in SF-36（P<0.05）;the scores of sexual desire were correlated with age,years of marriage,menopause or not,combining with heart disease,presence of vasculitis,dimensional scores of physical function and physical role function in SF-36（P<0.05）;the scores of sexual arousal were correlated with age,years of marriage,menopause or not,combining with heart disease,presence of vasculitis and pyuria,dimensional scores of physical function,physical role function and emotional function in SF-36（P<0.05）;the scores of vaginal lubrication degree were correlated with age,years of marriage,age at menarche,menopause or not,number of pregnancy,combining with heart disease,taking nonsteroidal antiinflammatory drugs,presence of vasculitis,pyuria and mucosal ulcer,dimensional scores of physical function,physical role function and emotional function in SF-36（P<0.05）;the scores of orgasm were correlated with age,years of marriage,menopause or not,combining with heart disease,taking nonsteroidal antiinflammatory drugs,presence of vasculitis and pyuria,physical function,dimensional scores of physical function,physical role function and emotional function in SF-36（P<0.05）;the scores of satisfaction degree of sexual life were correlated with age,years of marriage,menopause or not,age at menopause,combining with heart disease,presence of vasculitis and pleurisy,dimensional scores of physical function,physical role function and emotional function in SF-36（P<0.05）;the scores of dyspareunia were correlated with age,years of marriage,age at menarche,menopause or not,combining with heart disease,taking nonsteroidal antiinflammatory drugs,presence of vasculitis and pyuria,the dimensional scores of physical function,physical role function,body pain and emotional function（P<0.05）.Multiple linear regression analysis results showed that combining with heart disease was the influencing factor of scores of sexual desire,sexual arousal,vaginal lubrication and dyspareunia in FSFI among female SLE patients;presence of vasculitis was the influencing factor of total score and scores of sexual arousal,vaginal lubrication,orgasm and dyspareunia in FSFI;the dimensional score of physical role function was the influencing factor of scores of sexual arousal;mucosal ulcer was the influencing factor of scores of vaginal lubrication（P<0.05）.Conclusion　The Chinese female SLE patients present a high incidence of sexual dysfunction,and its main types are loss of libido and difficulties in sexual arousal,and combining with heart disease,presence of vasculitis and mucosal ulcers,and lacking in physical role function are the influencing factors.

Key words: Lupus erythematosus,systemic, Sexual dysfunction, Root cause analysis, Femininity

摘要： 目的　了解我国女性系统性红斑狼疮（SLE）患者的性功能障碍状况，并探讨其影响因素。方法　于2014年10月—2015年10月在南通大学附属医院选取女性SLE患者80例，并进行问卷调查。问卷包括一般资料调查表、中文版女性性功能量表（FSFI）、系统性红斑狼疮狼疮疾病活动指数（SLEDAI）、中文版简明生活质量评估量表（SF-36）4部分。共发放问卷85份，回收80份，问卷有效回收率为94.1%。结果　共61例（76.2%）患者存在性功能障碍，其中存在性欲减退58例（72.5%）、性唤起困难54例（67.5%）。患者FSFI总分与年龄、婚龄、初潮年龄、绝经与否、合并心脏病、服用非甾体类抗炎药，存在血管炎、脓尿，SF-36生理机能、生理职能、情感职能维度得分存在相关性（P<0.05）；性欲维度得分与年龄、婚龄、绝经与否、合并心脏病，存在血管炎，SF-36生理机能、生理职能维度得分存在相关性（P<0.05）；性唤起维度得分与年龄、婚龄、绝经与否、合并心脏病，存在血管炎、脓尿，SF-36生理机能、生理职能、情感职能维度得分存在相关性（P<0.05）；阴道润滑度维度得分与年龄、婚龄、初潮年龄、绝经与否、妊娠次数、合并心脏病、服用非甾体类抗炎药，存在血管炎、脓尿、黏膜溃疡，SF-36生理机能、生理职能、情感职能维度得分存在相关性（P<0.05）；性高潮维度得分与年龄、婚龄、绝经与否、合并心脏病、服用非甾体类抗炎药，存在血管炎、脓尿，SF-36生理机能、生理职能、情感职能维度得分存在相关性（P<0.05）；性生活满意度维度得分与年龄、婚龄、绝经与否、绝经年龄、合并心脏病，存在血管炎、胸膜炎，SF-36生理机能、生理职能、情感职能维度得分存在相关性（P<0.05）；性交疼痛维度得分与年龄、婚龄、初潮年龄、绝经与否、合并心脏病、服用非甾体类抗炎药，存在血管炎、脓尿，SF-36生理机能、生理职能、躯体疼痛、情感职能维度得分存在相关性（P<0.05）。多元线性回归分析结果显示，合并心脏病是女性SLE患者FSFI性欲、性唤起、阴道润滑度、性交疼痛维度得分的影响因素，存在血管炎是FSFI总分及性唤起、阴道润滑度、性高潮、性交疼痛维度得分的影响因素，SF-36生理职能维度得分是FSFI性唤起维度得分的影响因素，黏膜溃疡是FSFI阴道润滑度维度得分的影响因素，差异均有统计学意义（P<0.05）。结论　我国女性SLE患者的性功能障碍发生率较高，主要类型为性欲减退、性唤起困难，合并心脏病、存在血管炎和黏膜溃疡、生理职能缺失是其影响因素。

关键词: 红斑狼疮, 系统性, 性功能障碍, 影响因素分析, 女性