Abstract: Parkinson’s disease is a common neurodegenerative disease in elderly patients,involving degeneration of dopaminergic neuron in the substantia nigra.Parkinson’s disease is clinically characterized by four motor symptoms,known as bradykinesia,myotonia,abnormal posture and gait and resting tremor.Olfactory dysfunction,one of the most common non-motor symptoms which receive increasingly more attention in academic circle,contributes to a serious loss of quality of life.In this article,advances in olfactory dysfunction in recent years are reviewed in aspects of epidemiology,mechanism and its treatment.

Key words: Parkinson disease, Olfaction disorders, Review

摘要： 帕金森病是好发于中老年人群的一种神经退行性疾病，其病理改变涉及脑黑质多巴胺能神经元的变性。典型的运动系统症状包括静止性震颤、肌强直、运动迟缓以及姿势步态异常。近年来，帕金森病的非运动症状逐渐引起学界的关注，嗅觉障碍作为帕金森病非运动系统症状之一，可显著影响患者的生活质量。关于帕金森病嗅觉障碍的研究近年来有了新的进展，本文就帕金森病嗅觉障碍的流行病学、发生机制及治疗等方面的研究进展做一综述。

关键词: 帕金森病, 嗅觉障碍, 综述