Abstract: IgA vasculitis is a common systemic small vasculitis in childhood. Its pathogenesis is mainly caused by IgA immune complex deposition，manifested as skin purpura with or without digestive tract injury，joint injury and kidney involvement. The long-term prognosis is mainly related to the severity of kidney damage，and some may develop into endstage renal disease，which endangers the physical and mental health of children. The etiology，pathogenesis and progression mechanism of IgA vasculitis are complex and have not been determined so far. As an effective tool for disease research，omics technology has been gradually applied to the search for biomarkers at different molecular levels of IgA vasculitis and the exploration of pathogenesis，progression and other mechanisms，and has achieved certain results. By reviewing the current literature on IgA vasculitis，this paper summarizes and analyzes the application status and progress of various omics techniques in IgA vasculitis，in order to provide ideas and directions for further research on IgA vasculitis in the future.

Key words: IgA vasculitis, IgA vasculitis nephritis, Multi-omics, Genomics, Transcriptomics, Proteomics, Metabolomics

摘要： IgA血管炎是儿童时期常见的一种系统性小血管炎，其发病由IgA免疫复合物沉积为主，表现为皮肤紫癜伴或不伴消化道损伤、关节损伤及肾脏受累，远期预后主要与肾脏损害的严重程度有关，部分可能发展为终末期肾病，危害着儿童的身心健康。IgA血管炎的病因及发病、进展机制复杂，至今尚无定论。组学技术作为疾病研究的有效工具，逐渐被应用于IgA血管炎不同分子层次上生物标志物的寻找及其发病、进展等机制的探索，并取得一定的效果。本文通过梳理目前IgA血管炎的组学研究文献，总结并分析了多种组学技术在IgA血管炎中的应用现状与进展，以期为今后更深入地研究IgA血管炎提供思路和方向。

关键词: IgA 血管炎, IgA 血管炎肾炎, 多组学, 基因组学, 转录组学, 蛋白质组学, 代谢组学