Advances in the Application of Precision Medicine-based Approach for Guiding the Diagnosis and Treatment of Chronic Hepatitis C

doi:10.3969/j.issn.1007-9572.2018.00.078

Abstract

Abstract: Hepatitis C（HCV），with strong infectiousness and highly variable viral genome，has been widely spread，causing global public health problems.Precision medicine，based on individualized treatment，is a hot spot attracting the attention of both the public and the academic realm.A large number of medical frontier technologies are used to develop the precision medical model for the prevention and treatment of specific patients.This paper reviews the impact of HCV genotyping on the diagnosis of hepatitis C，achievements in genomics，proteomics，pharmaco metabonomics and other high-throughput proteomic technologies，biomarkers and potential therapeutic targets related to HCV diagnosis and treatment，as well as the prospect of precision medicine-based approach used for the guide of chronic HCV diagnosis，treatment and prognosis assessment.

Key words: Precision medicine, Hepatitis C, Genomics, Proteomics, Metabolomics, Biomarker

摘要： 丙型肝炎传染性强、流行面广，病毒基因组高度变异，是全球性公共卫生难题之一。精准医疗是以个体化治疗为基础应用大量医学前沿技术针对特定患者制定相应的疾病预防与治疗的医疗模式，是目前公众和学术关注的热点。本文综述了丙型肝炎病毒基因分型在丙型肝炎分型诊断中的作用，丙型肝炎在基因组学、蛋白质组学、药物代谢组学等高通量组学技术方面的发展，丙型肝炎生物标志物及潜在治疗靶点等研究成果，探讨精准医学理念在丙型肝炎诊断、治疗及预后中的应用前景。

关键词: 精准医学, 丙型肝炎, 基因组学, 蛋白质组学, 代谢组学, 生物标志物

LU Ming-zi,ZHU Wei,ZHANG Xiao-kun, et al. Advances in the Application of Precision Medicine-based Approach for Guiding the Diagnosis and Treatment of Chronic Hepatitis C[J]. Chinese General Practice, 2018, 21(27): 3393-3396. DOI: 10.3969/j.issn.1007-9572.2018.00.078.
卢明子,朱伟,张晓琨等. 精准医学理念在丙型肝炎诊治中的应用进展[J]. 中国全科医学, 2018, 21(27): 3393-3396. DOI: 10.3969/j.issn.1007-9572.2018.00.078.

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