Chinese General Practice ›› 2022, Vol. 25 ›› Issue (23): 2903-2909.DOI: 10.12114/j.issn.1007-9572.2022.0122

Special Issue: 神经退行性病变最新文章合集 阿尔茨海默病最新文章合集

• Research of Brain Health:Cognitive Dysfunction • Previous Articles     Next Articles

Advances in the Mechanism of Enriched Environment Improving Chronic Cerebral Hypoperfusion-induced Cognitive Impairment

  

  1. 1School of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450000, China
    2Department of Rehabilitation, the First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, China
  • Received:2022-02-07 Revised:2022-03-10 Published:2022-08-15 Online:2022-03-24
  • Contact: Xiaodong FENG
  • About author:
    LIU H H, GAO J, SU K Q, et al. Advances in the mechanism of enriched environment improving chronic cerebral hypoperfusion-induced cognitive impairment[J]. Chinese General Practice, 2022, 25 (23) : 2903-2909.

丰富环境对慢性低灌注性认知障碍保护作用的机制研究进展

  

  1. 1450000 河南省郑州市,河南中医药大学康复医学院
    2450000 河南省郑州市,河南中医药大学第一附属医院康复科
  • 通讯作者: 冯晓东
  • 作者简介:
    刘环环,高静,苏凯奇,等. 丰富环境对慢性低灌注性认知障碍保护作用的机制研究进展[J]. 中国全科医学,2022,25(23):2903-2909. [www.chinagp.net] 作者贡献:刘环环进行文章的构思,负责撰写论文;刘环环、苏凯奇负责文献/ 资料收集、整理;高静进行论文修订;冯晓东负责文章质量控制及审校,对文章整体负责。
  • 基金资助:
    国家自然科学基金资助项目(81574042,U2004131)

Abstract:

Chronic cerebral hypoperfusion-induced cognitive impairment (CCHCI) is a cognitive deficit caused by cerebral cortex or subcortical infarction, white matter degeneration, blood-cerebrospinal fluid barrier, and hippocampal injury due to long-term hypoperfusion of the brain. Clinical evidence shows that there is still no effective pharmacological treatment for CCHCI. But numerous animal studies have demonstrated that enriched environment can alleviate brain tissue damage caused by chronic hypoperfusion and promote nerve growth and functional recovery in ischemic brain areas. We reviewed the latest advances in the use of enriched environment as a non-drug intervention for CCHCI in animal models via regulating autophagy and epigenetic mechanisms to inhibit oxidative stress, protect the blood-cerebrospinal fluid barrier, promote neurovascular reconstruction and stimulate synaptic plasticity. We hope the review could provide new ideas for the treatment and clinical research of CCHCI to reverse CCHCI-induced neurological impairment and improve cognitive impairment.

Key words: Cognition disorders, Brain ischemia, Chronic hypoperfusion, Environmental enrichment, Epigenomics, Trauma, nervous system, Review

摘要:

慢性低灌注性认知障碍是因大脑长期处于低灌注状态,导致脑皮质或皮质下梗死、脑白质变性、血-脑脊液屏障及海马等损伤而出现的一种认知缺陷。目前,慢性低灌注性认知障碍在临床治疗中尚未发现有效的治疗药物。大量动物研究表明丰富环境干预能减轻慢性低灌注造成的脑组织损伤,促进缺血脑区的神经生长和功能恢复。为此,本文总结了丰富环境作为非药物干预方式通过调控细胞自噬及表观遗传机制、抑制氧化应激、保护血-脑脊液屏障、促进神经血管重建和突触可塑性的研究进展,为慢性低灌注性认知障碍的治疗及临床研究提供新的思路,逆转慢性低灌注造成的神经功能损伤,改善认知障碍。

关键词: 认知障碍, 脑缺血, 慢性低灌注, 丰富环境, 表观基因组学, 创伤,神经系统, 综述