Chinese General Practice ›› 2024, Vol. 27 ›› Issue (17): 2091-2097.DOI: 10.12114/j.issn.1007-9572.2023.0673
• Original Research • Previous Articles Next Articles
Received:
2023-11-20
Revised:
2024-02-18
Published:
2024-06-15
Online:
2024-03-22
Contact:
SUN Jing, LIN Genlai
通讯作者:
孙菁, 林根来
作者简介:
基金资助:
CLC Number:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0673
项目 | 例数 | 5年 | 10年 | ||||
---|---|---|---|---|---|---|---|
生存率 | χ2值 | P值 | 生存率 | χ2值 | P值 | ||
年龄(岁) | 4.727 | 0.094 | 5.295 | 0.071 | |||
≤40 | 18 | 6(33.3) | 5(27.8) | ||||
41~60 | 71 | 40(55.6) | 30(41.7) | ||||
>60 | 46 | 27(60.0) | 26(57.8) | ||||
性别 | 0.348 | 0.555 | 0.018 | 0.892 | |||
男 | 97 | 51(52.6) | 45(46.4) | ||||
女 | 38 | 22(57.9) | 16(42.1) | ||||
pTNM分期(期) | 15.809 | <0.001 | 17.736 | <0.001 | |||
ⅢA | 39 | 28(71.8) | 26(66.7) | ||||
ⅢB | 56 | 33(58.9) | 26(46.4) | ||||
ⅢC | 40 | 12(30.0) | 9(22.5) | ||||
pT分期(期) | 4.998 | 0.025 | 5.992 | 0.014 | |||
T1~3 | 29 | 21(72.4) | 19(65.5) | ||||
T4 | 106 | 52(49.1) | 42(39.6) | ||||
pN分期(期) | 3.306 | 0.069 | 3.333 | 0.068 | |||
N0~2 | 42 | 28(66.7) | 24(57.1) | ||||
N3 | 93 | 45(48.4) | 37(39.7) | ||||
LNR(%) | 18.464 | <0.001 | 15.621 | 0.001 | |||
≤50 | 91 | 60(65.9) | 50(54.9) | ||||
>50 | 44 | 13(29.5) | 11(25.0) | ||||
癌结节 | 4.984 | 0.026 | 2.072 | 0.150 | |||
无 | 110 | 63(57.3) | 51(46.4) | ||||
有 | 25 | 10(41.7) | 10(41.7) | ||||
病理组织类型 | 1.237 | 0.266 | 1.330 | 0.249 | |||
腺癌 | 123 | 65(52.8) | 54(43.9) | ||||
非腺癌 | 12 | 8(66.7) | 7(58.3) | ||||
脉管癌栓 | 2.425 | 0.119 | 2.364 | 0.124 | |||
有 | 48 | 22(45.8) | 18(37.5) | ||||
无 | 87 | 51(58.6) | 43(49.4) | ||||
神经浸润 | 2.650 | 0.104 | 3.923 | 0.048 | |||
有 | 76 | 37(48.7) | 29(38.2) | ||||
无 | 59 | 36(61.0) | 32(54.2) | ||||
肿瘤位置 | 4.959 | 0.026 | 2.056 | 0.152 | |||
胃窦 | 62 | 40(64.5) | 31(50.0) | ||||
贲门+胃体 | 73 | 33(45.2) | 30(41.1) | ||||
胃切除方式 | 14.667 | <0.001 | 11.775 | 0.001 | |||
次全胃切除术 | 107 | 65(60.7) | 54(50.5) | ||||
全胃切除术 | 28 | 8(28.6) | 7(25.0) |
Table 1 Analysis of 5-year and 10-year survival rates of patients with different baseline data
项目 | 例数 | 5年 | 10年 | ||||
---|---|---|---|---|---|---|---|
生存率 | χ2值 | P值 | 生存率 | χ2值 | P值 | ||
年龄(岁) | 4.727 | 0.094 | 5.295 | 0.071 | |||
≤40 | 18 | 6(33.3) | 5(27.8) | ||||
41~60 | 71 | 40(55.6) | 30(41.7) | ||||
>60 | 46 | 27(60.0) | 26(57.8) | ||||
性别 | 0.348 | 0.555 | 0.018 | 0.892 | |||
男 | 97 | 51(52.6) | 45(46.4) | ||||
女 | 38 | 22(57.9) | 16(42.1) | ||||
pTNM分期(期) | 15.809 | <0.001 | 17.736 | <0.001 | |||
ⅢA | 39 | 28(71.8) | 26(66.7) | ||||
ⅢB | 56 | 33(58.9) | 26(46.4) | ||||
ⅢC | 40 | 12(30.0) | 9(22.5) | ||||
pT分期(期) | 4.998 | 0.025 | 5.992 | 0.014 | |||
T1~3 | 29 | 21(72.4) | 19(65.5) | ||||
T4 | 106 | 52(49.1) | 42(39.6) | ||||
pN分期(期) | 3.306 | 0.069 | 3.333 | 0.068 | |||
N0~2 | 42 | 28(66.7) | 24(57.1) | ||||
N3 | 93 | 45(48.4) | 37(39.7) | ||||
LNR(%) | 18.464 | <0.001 | 15.621 | 0.001 | |||
≤50 | 91 | 60(65.9) | 50(54.9) | ||||
>50 | 44 | 13(29.5) | 11(25.0) | ||||
癌结节 | 4.984 | 0.026 | 2.072 | 0.150 | |||
无 | 110 | 63(57.3) | 51(46.4) | ||||
有 | 25 | 10(41.7) | 10(41.7) | ||||
病理组织类型 | 1.237 | 0.266 | 1.330 | 0.249 | |||
腺癌 | 123 | 65(52.8) | 54(43.9) | ||||
非腺癌 | 12 | 8(66.7) | 7(58.3) | ||||
脉管癌栓 | 2.425 | 0.119 | 2.364 | 0.124 | |||
有 | 48 | 22(45.8) | 18(37.5) | ||||
无 | 87 | 51(58.6) | 43(49.4) | ||||
神经浸润 | 2.650 | 0.104 | 3.923 | 0.048 | |||
有 | 76 | 37(48.7) | 29(38.2) | ||||
无 | 59 | 36(61.0) | 32(54.2) | ||||
肿瘤位置 | 4.959 | 0.026 | 2.056 | 0.152 | |||
胃窦 | 62 | 40(64.5) | 31(50.0) | ||||
贲门+胃体 | 73 | 33(45.2) | 30(41.1) | ||||
胃切除方式 | 14.667 | <0.001 | 11.775 | 0.001 | |||
次全胃切除术 | 107 | 65(60.7) | 54(50.5) | ||||
全胃切除术 | 28 | 8(28.6) | 7(25.0) |
变量 | 单因素分析 | 多因素分析 | ||||
---|---|---|---|---|---|---|
HR | 95%CI | P值 | HR | 95%CI | P值 | |
年龄(以>60岁为参照) | ||||||
≤40岁 | 2.26 | 1.11~4.59 | 0.024 | 2.19 | 1.06~4.53 | 0.035 |
41~60岁 | 1.37 | 0.79~2.35 | 0.259 | 1.27 | 0.74~2.20 | 0.392 |
性别(以女为参照) | ||||||
男 | 1.04 | 0.63~1.71 | 0.892 | |||
pTNM分期(以ⅢC期为参照) | ||||||
ⅢA期 | 0.28 | 0.15~0.53 | <0.001 | 0.40 | 0.19~0.83 | 0.014 |
ⅢB期 | 0.51 | 0.31~0.85 | 0.010 | 0.73 | 0.42~1.27 | 0.270 |
pT分期(以T1~3期为参照) | ||||||
T4期 | 2.25 | 1.15~4.38 | 0.017 | |||
pN分期(以N0~2期为参照) | ||||||
N3期 | 1.63 | 0.96~2.78 | 0.071 | |||
LNR(以≤50%为参照) | ||||||
>50% | 2.46 | 1.55~3.91 | <0.001 | 1.74 | 1.03~2.94 | 0.039 |
癌结节(以无为参照) | ||||||
有 | 1.51 | 0.86~2.67 | 0.153 | |||
病理类型(以非腺癌为参照) | ||||||
腺癌 | 0.59 | 0.24~1.46 | 0.254 | |||
肿瘤位置(以胃窦为参照) | ||||||
非胃窦 | 1.40 | 0.88~2.22 | 0.154 | |||
脉管浸润(以无为参照) | ||||||
有 | 1.44 | 0.90~2.29 | 0.126 | |||
神经浸润(以无为参照) | ||||||
有 | 1.61 | 1.00~2.58 | 0.050 | 1.31 | 0.80~2.16 | 0.280 |
胃切除方式(以次全胃切除术为参照) | ||||||
全胃切除术 | 2.37 | 1.43~3.95 | 0.007 | 2.07 | 1.22~3.50 | 0.007 |
Table 2 Univariate and multivariate Cox proportional risk regression analysis of factors influencing patients overall survival time
变量 | 单因素分析 | 多因素分析 | ||||
---|---|---|---|---|---|---|
HR | 95%CI | P值 | HR | 95%CI | P值 | |
年龄(以>60岁为参照) | ||||||
≤40岁 | 2.26 | 1.11~4.59 | 0.024 | 2.19 | 1.06~4.53 | 0.035 |
41~60岁 | 1.37 | 0.79~2.35 | 0.259 | 1.27 | 0.74~2.20 | 0.392 |
性别(以女为参照) | ||||||
男 | 1.04 | 0.63~1.71 | 0.892 | |||
pTNM分期(以ⅢC期为参照) | ||||||
ⅢA期 | 0.28 | 0.15~0.53 | <0.001 | 0.40 | 0.19~0.83 | 0.014 |
ⅢB期 | 0.51 | 0.31~0.85 | 0.010 | 0.73 | 0.42~1.27 | 0.270 |
pT分期(以T1~3期为参照) | ||||||
T4期 | 2.25 | 1.15~4.38 | 0.017 | |||
pN分期(以N0~2期为参照) | ||||||
N3期 | 1.63 | 0.96~2.78 | 0.071 | |||
LNR(以≤50%为参照) | ||||||
>50% | 2.46 | 1.55~3.91 | <0.001 | 1.74 | 1.03~2.94 | 0.039 |
癌结节(以无为参照) | ||||||
有 | 1.51 | 0.86~2.67 | 0.153 | |||
病理类型(以非腺癌为参照) | ||||||
腺癌 | 0.59 | 0.24~1.46 | 0.254 | |||
肿瘤位置(以胃窦为参照) | ||||||
非胃窦 | 1.40 | 0.88~2.22 | 0.154 | |||
脉管浸润(以无为参照) | ||||||
有 | 1.44 | 0.90~2.29 | 0.126 | |||
神经浸润(以无为参照) | ||||||
有 | 1.61 | 1.00~2.58 | 0.050 | 1.31 | 0.80~2.16 | 0.280 |
胃切除方式(以次全胃切除术为参照) | ||||||
全胃切除术 | 2.37 | 1.43~3.95 | 0.007 | 2.07 | 1.22~3.50 | 0.007 |
变量 | 单因素分析 | 多因素分析 | ||||
---|---|---|---|---|---|---|
HR | 95%CI | P值 | HR | 95%CI | P值 | |
年龄(以>60岁为参照) | ||||||
≤40岁 | 2.15 | 1.06~4.36 | 0.034 | 2.05 | 0.99~4.24 | 0.054 |
41~60岁 | 1.37 | 0.80~2.36 | 0.254 | 1.29 | 0.74~2.23 | 0.370 |
性别(以女为参照) | ||||||
男 | 1.08 | 0.64~1.79 | 0.748 | |||
pTNM分期(以ⅢC期为参照) | ||||||
ⅢA期 | 0.28 | 0.15~0.53 | <0.001 | 0.40 | 0.19~0.82 | 0.009 |
ⅢB期 | 0.53 | 0.32~0.88 | 0.014 | 0.74 | 0.43~1.29 | 0.291 |
pT分期(以T1~3期为参照) | ||||||
T4期 | 2.18 | 1.12~4.24 | 0.022 | |||
pN分期(以N0~2期为参照) | ||||||
N3期 | 1.64 | 0.97~2.80 | 0.067 | |||
LNR(以≤50%为参照) | ||||||
>50% | 2.41 | 1.52~3.82 | <0.001 | 1.73 | 1.02~2.94 | 0.043 |
癌结节(以无为参照) | ||||||
有 | 1.46 | 0.83~2.58 | 0.192 | |||
病理类型(以非腺癌为参照) | ||||||
腺癌 | 0.65 | 0.26~1.62 | 0.356 | |||
肿瘤位置(以胃窦为参照) | ||||||
非胃窦 | 1.49 | 0.94~2.37 | 0.090 | |||
脉管浸润(以无为参照) | ||||||
有 | 1.44 | 0.90~2.29 | 0.126 | |||
神经浸润(以无为参照) | ||||||
有 | 1.63 | 1.02~2.62 | 0.043 | 1.42 | 0.87~2.32 | 0.164 |
胃切除方式(以次全胃切除术为参照) | ||||||
全胃切除术 | 2.35 | 1.41~3.91 | 0.001 | 2.02 | 1.20~3.41 | 0.008 |
Table 3 Univariate and multivariate Cox proportional risk regression analysis of factors influencing patients disease-free survival time
变量 | 单因素分析 | 多因素分析 | ||||
---|---|---|---|---|---|---|
HR | 95%CI | P值 | HR | 95%CI | P值 | |
年龄(以>60岁为参照) | ||||||
≤40岁 | 2.15 | 1.06~4.36 | 0.034 | 2.05 | 0.99~4.24 | 0.054 |
41~60岁 | 1.37 | 0.80~2.36 | 0.254 | 1.29 | 0.74~2.23 | 0.370 |
性别(以女为参照) | ||||||
男 | 1.08 | 0.64~1.79 | 0.748 | |||
pTNM分期(以ⅢC期为参照) | ||||||
ⅢA期 | 0.28 | 0.15~0.53 | <0.001 | 0.40 | 0.19~0.82 | 0.009 |
ⅢB期 | 0.53 | 0.32~0.88 | 0.014 | 0.74 | 0.43~1.29 | 0.291 |
pT分期(以T1~3期为参照) | ||||||
T4期 | 2.18 | 1.12~4.24 | 0.022 | |||
pN分期(以N0~2期为参照) | ||||||
N3期 | 1.64 | 0.97~2.80 | 0.067 | |||
LNR(以≤50%为参照) | ||||||
>50% | 2.41 | 1.52~3.82 | <0.001 | 1.73 | 1.02~2.94 | 0.043 |
癌结节(以无为参照) | ||||||
有 | 1.46 | 0.83~2.58 | 0.192 | |||
病理类型(以非腺癌为参照) | ||||||
腺癌 | 0.65 | 0.26~1.62 | 0.356 | |||
肿瘤位置(以胃窦为参照) | ||||||
非胃窦 | 1.49 | 0.94~2.37 | 0.090 | |||
脉管浸润(以无为参照) | ||||||
有 | 1.44 | 0.90~2.29 | 0.126 | |||
神经浸润(以无为参照) | ||||||
有 | 1.63 | 1.02~2.62 | 0.043 | 1.42 | 0.87~2.32 | 0.164 |
胃切除方式(以次全胃切除术为参照) | ||||||
全胃切除术 | 2.35 | 1.41~3.91 | 0.001 | 2.02 | 1.20~3.41 | 0.008 |
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