Chinese General Practice ›› 2023, Vol. 26 ›› Issue (30): 3785-3790.DOI: 10.12114/j.issn.1007-9572.2023.0241
• Original Research • Previous Articles Next Articles
Received:
2023-01-13
Revised:
2023-05-24
Published:
2023-10-20
Online:
2023-05-21
Contact:
ZHU Shuchai
通讯作者:
祝淑钗
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0241
项目 | 例数 | 5年总生存率(%) | χ2值 | P值 | 5年无进展生存率(%) | χ2值 | P值 | 5年无局部区域复发生存率(%) | χ2值 | P值 | 5年无远转生存率(%) | χ2值 | P值 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
年龄 | 0.732 | 0.392 | 0.543 | 0.461 | 1.103 | 0.294 | 0.619 | 0.432 | |||||
<64岁 | 51 | 41.0 | 37.3 | 39.1 | 37.3 | ||||||||
≥64岁 | 55 | 45.0 | 38.2 | 43.5 | 39.6 | ||||||||
性别 | 2.120 | 0.145 | 4.449 | 0.035 | 3.419 | 0.064 | 3.399 | 0.065 | |||||
男 | 61 | 37.4 | 31.1 | 35.8 | 31.1 | ||||||||
女 | 45 | 50.6 | 46.7 | 48.9 | 48.6 | ||||||||
吸烟史 | 2.227 | 0.136 | 4.545 | 0.033 | 2.801 | 0.094 | 4.834 | 0.028 | |||||
有 | 47 | 37.9 | 29.8 | 33.6 | 29.5 | ||||||||
无 | 59 | 47.1 | 44.1 | 45.6 | 45.8 | ||||||||
肿瘤部位 | 3.174 | 0.075 | 1.942 | 0.163 | 1.936 | 0.164 | 2.132 | 0.144 | |||||
颈段 | 23 | 50.5 | 39.1 | 42.4 | 43.0 | ||||||||
胸上段 | 83 | 40.9 | 37.1 | 39.6 | 37.3 | ||||||||
肿瘤长度 | 6.440 | 0.011 | 5.973 | 0.015 | 6.101 | 0.014 | 5.150 | 0.023 | |||||
<6 cm | 57 | 51.7 | 45.6 | 48.7 | 47.1 | ||||||||
≥6 cm | 49 | 30.5 | 28.6 | 30.5 | 28.6 | ||||||||
T分期 | 9.136 | 0.003 | 12.648 | <0.001 | 8.953 | 0.003 | 10.791 | 0.001 | |||||
T1/T2期 | 45 | 59.7 | 55.6 | 55.6 | 57.8 | ||||||||
T3/T4期 | 61 | 30.8 | 24.6 | 30.0 | 24.5 | ||||||||
N分期 | 7.765 | 0.005 | 7.877 | 0.005 | 5.653 | 0.017 | 8.960 | 0.003 | |||||
N0期 | 35 | 62.7 | 57.1 | 57.1 | 60.0 | ||||||||
N1/N2期 | 71 | 33.1 | 28.2 | 32.5 | 27.8 | ||||||||
TNM分期 | 18.566 | <0.001 | 16.111 | <0.001 | 14.408 | <0.001 | 18.719 | <0.001 | |||||
Ⅰ/Ⅱ期 | 69 | 54.7 | 49.3 | 52.1 | 50.5 | ||||||||
Ⅲ期 | 37 | 21.3 | 16.2 | 21.3 | 16.2 | ||||||||
放疗剂量 | 0.713 | 0.398 | 0.554 | 0.457 | 0.962 | 0.327 | 0.450 | 0.503 | |||||
<61.8 Gy | 47 | 45.5 | 38.3 | 41.6 | 39.7 | ||||||||
≥61.8 Gy | 59 | 40.7 | 37.3 | 39.0 | 37.3 | ||||||||
照射方式 | 14.278 | <0.001 | 14.041 | <0.001 | 13.234 | <0.001 | 13.372 | <0.001 | |||||
ENI | 72 | 52.5 | 47.2 | 49.9 | 48.4 | ||||||||
IFI | 34 | 22.7 | 17.6 | 21.0 | 17.6 | ||||||||
巩固化疗 | 5.283 | 0.022 | 5.230 | 0.022 | 5.628 | 0.018 | 3.770 | 0.052 | |||||
是 | 69 | 51.9 | 46.4 | 49.0 | 46.2 | ||||||||
否 | 37 | 26.4 | 21.6 | 24.0 | 24.3 | ||||||||
dNLR | 5.453 | 0.020 | 9.595 | 0.002 | 5.355 | 0.021 | 8.503 | 0.004 | |||||
<2.15 | 64 | 49.7 | 46.9 | 48.4 | 46.9 | ||||||||
≥2.15 | 42 | 32.6 | 23.8 | 30.3 | 26.2 |
Table 1 Single factor analysis of OS,PFS,LRRFS and DMFS
项目 | 例数 | 5年总生存率(%) | χ2值 | P值 | 5年无进展生存率(%) | χ2值 | P值 | 5年无局部区域复发生存率(%) | χ2值 | P值 | 5年无远转生存率(%) | χ2值 | P值 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
年龄 | 0.732 | 0.392 | 0.543 | 0.461 | 1.103 | 0.294 | 0.619 | 0.432 | |||||
<64岁 | 51 | 41.0 | 37.3 | 39.1 | 37.3 | ||||||||
≥64岁 | 55 | 45.0 | 38.2 | 43.5 | 39.6 | ||||||||
性别 | 2.120 | 0.145 | 4.449 | 0.035 | 3.419 | 0.064 | 3.399 | 0.065 | |||||
男 | 61 | 37.4 | 31.1 | 35.8 | 31.1 | ||||||||
女 | 45 | 50.6 | 46.7 | 48.9 | 48.6 | ||||||||
吸烟史 | 2.227 | 0.136 | 4.545 | 0.033 | 2.801 | 0.094 | 4.834 | 0.028 | |||||
有 | 47 | 37.9 | 29.8 | 33.6 | 29.5 | ||||||||
无 | 59 | 47.1 | 44.1 | 45.6 | 45.8 | ||||||||
肿瘤部位 | 3.174 | 0.075 | 1.942 | 0.163 | 1.936 | 0.164 | 2.132 | 0.144 | |||||
颈段 | 23 | 50.5 | 39.1 | 42.4 | 43.0 | ||||||||
胸上段 | 83 | 40.9 | 37.1 | 39.6 | 37.3 | ||||||||
肿瘤长度 | 6.440 | 0.011 | 5.973 | 0.015 | 6.101 | 0.014 | 5.150 | 0.023 | |||||
<6 cm | 57 | 51.7 | 45.6 | 48.7 | 47.1 | ||||||||
≥6 cm | 49 | 30.5 | 28.6 | 30.5 | 28.6 | ||||||||
T分期 | 9.136 | 0.003 | 12.648 | <0.001 | 8.953 | 0.003 | 10.791 | 0.001 | |||||
T1/T2期 | 45 | 59.7 | 55.6 | 55.6 | 57.8 | ||||||||
T3/T4期 | 61 | 30.8 | 24.6 | 30.0 | 24.5 | ||||||||
N分期 | 7.765 | 0.005 | 7.877 | 0.005 | 5.653 | 0.017 | 8.960 | 0.003 | |||||
N0期 | 35 | 62.7 | 57.1 | 57.1 | 60.0 | ||||||||
N1/N2期 | 71 | 33.1 | 28.2 | 32.5 | 27.8 | ||||||||
TNM分期 | 18.566 | <0.001 | 16.111 | <0.001 | 14.408 | <0.001 | 18.719 | <0.001 | |||||
Ⅰ/Ⅱ期 | 69 | 54.7 | 49.3 | 52.1 | 50.5 | ||||||||
Ⅲ期 | 37 | 21.3 | 16.2 | 21.3 | 16.2 | ||||||||
放疗剂量 | 0.713 | 0.398 | 0.554 | 0.457 | 0.962 | 0.327 | 0.450 | 0.503 | |||||
<61.8 Gy | 47 | 45.5 | 38.3 | 41.6 | 39.7 | ||||||||
≥61.8 Gy | 59 | 40.7 | 37.3 | 39.0 | 37.3 | ||||||||
照射方式 | 14.278 | <0.001 | 14.041 | <0.001 | 13.234 | <0.001 | 13.372 | <0.001 | |||||
ENI | 72 | 52.5 | 47.2 | 49.9 | 48.4 | ||||||||
IFI | 34 | 22.7 | 17.6 | 21.0 | 17.6 | ||||||||
巩固化疗 | 5.283 | 0.022 | 5.230 | 0.022 | 5.628 | 0.018 | 3.770 | 0.052 | |||||
是 | 69 | 51.9 | 46.4 | 49.0 | 46.2 | ||||||||
否 | 37 | 26.4 | 21.6 | 24.0 | 24.3 | ||||||||
dNLR | 5.453 | 0.020 | 9.595 | 0.002 | 5.355 | 0.021 | 8.503 | 0.004 | |||||
<2.15 | 64 | 49.7 | 46.9 | 48.4 | 46.9 | ||||||||
≥2.15 | 42 | 32.6 | 23.8 | 30.3 | 26.2 |
项目 | β | SE | Wald χ2值 | P值 | HR(95%CI) |
---|---|---|---|---|---|
OS | |||||
TNM分期 | 0.622 | 0.286 | 4.737 | 0.030 | 1.863(1.064,3.262) |
照射方式 | 0.680 | 0.275 | 6.131 | 0.013 | 1.973(1.152,3.380) |
PFS | |||||
TNM分期 | 0.842 | 0.293 | 8.253 | 0.004 | 2.320(1.307,4.120) |
照射方式 | 0.749 | 0.268 | 7.793 | 0.005 | 2.114(1.250,3.577) |
dNLR | 0.589 | 0.263 | 5.018 | 0.025 | 1.803(1.076,3.019) |
LRRFS | |||||
性别 | 0.693 | 0.287 | 5.842 | 0.016 | 1.999(1.140,3.505) |
TNM分期 | 0.738 | 0.290 | 6.464 | 0.011 | 2.092(1.184,3.696) |
照射方式 | 0.724 | 0.268 | 7.290 | 0.007 | 2.062(1.219,3.486) |
DMFS | |||||
TNM分期 | 0.964 | 0.298 | 10.452 | 0.001 | 2.622(1.462,4.704) |
照射方式 | 0.698 | 0.272 | 6.568 | 0.010 | 2.010(1.178,3.427) |
dNLR | 0.638 | 0.264 | 5.863 | 0.015 | 1.893(1.129,3.174) |
Table 2 Multivariate Cox proportional hazard regression analysis of influencing factors of OS,PFS,LRRFS and DMFS of patients
项目 | β | SE | Wald χ2值 | P值 | HR(95%CI) |
---|---|---|---|---|---|
OS | |||||
TNM分期 | 0.622 | 0.286 | 4.737 | 0.030 | 1.863(1.064,3.262) |
照射方式 | 0.680 | 0.275 | 6.131 | 0.013 | 1.973(1.152,3.380) |
PFS | |||||
TNM分期 | 0.842 | 0.293 | 8.253 | 0.004 | 2.320(1.307,4.120) |
照射方式 | 0.749 | 0.268 | 7.793 | 0.005 | 2.114(1.250,3.577) |
dNLR | 0.589 | 0.263 | 5.018 | 0.025 | 1.803(1.076,3.019) |
LRRFS | |||||
性别 | 0.693 | 0.287 | 5.842 | 0.016 | 1.999(1.140,3.505) |
TNM分期 | 0.738 | 0.290 | 6.464 | 0.011 | 2.092(1.184,3.696) |
照射方式 | 0.724 | 0.268 | 7.290 | 0.007 | 2.062(1.219,3.486) |
DMFS | |||||
TNM分期 | 0.964 | 0.298 | 10.452 | 0.001 | 2.622(1.462,4.704) |
照射方式 | 0.698 | 0.272 | 6.568 | 0.010 | 2.010(1.178,3.427) |
dNLR | 0.638 | 0.264 | 5.863 | 0.015 | 1.893(1.129,3.174) |
毒副作用 | 例数 | 分级 | ||
---|---|---|---|---|
2级 | 3级 | 4级 | ||
急性放射性肺炎 | 10 | 7 | 2 | 1 |
放射性食管炎 | 25 | 21 | 4 | 0 |
白细胞减少 | 32 | 23 | 7 | 2 |
贫血 | 9 | 7 | 2 | 0 |
血小板减少 | 11 | 8 | 2 | 1 |
Table 3 Treatment-related toxic and side effects grading of patients
毒副作用 | 例数 | 分级 | ||
---|---|---|---|---|
2级 | 3级 | 4级 | ||
急性放射性肺炎 | 10 | 7 | 2 | 1 |
放射性食管炎 | 25 | 21 | 4 | 0 |
白细胞减少 | 32 | 23 | 7 | 2 |
贫血 | 9 | 7 | 2 | 0 |
血小板减少 | 11 | 8 | 2 | 1 |
[1] |
|
[2] |
|
[3] |
|
[4] |
|
[5] |
|
[6] |
|
[7] |
|
[8] |
|
[9] |
|
[10] |
中国医师协会放射肿瘤治疗医师分会,中华医学会放射肿瘤治疗学分会,中国抗癌协会肿瘤放射治疗专业委员会. 中国食管癌放射治疗指南(2022年版)[J]. 国际肿瘤学杂志,2022,49(11):12-25. DOI:10.3760/cma.j.cn371439-20221011-00129.
|
[11] |
|
[12] |
郑荣寿,张思维,孙可欣,等. 2016年中国恶性肿瘤流行情况分析[J]. 中华肿瘤杂志,2023,45(3):212-220. DOI:10.3760/cma.j.cn112152-20220922-00647.
|
[13] |
|
[14] |
|
[15] |
|
[16] |
|
[17] |
|
[18] |
|
[19] |
|
[20] |
|
[21] |
李巧芳,李曙光,许金蕊,等. 食管癌根治性调强放疗靶区范围对预后生存的影响[J]. 中华放射医学与防护杂志,2020,40(8):600-605. DOI:10.3760/cma.j.issn.0254-5098.2020.08.005.
|
[22] |
孙小兵,柏会明,吴少兵,等. 放疗照射方式差异对行同步放化疗颈胸上段食管癌患者预后及安全性的影响[J]. 现代肿瘤医学,2021,29(23):4134-4137. DOI:10.3969/j.issn.1672-4992.2021.23.012.
|
[23] |
|
[24] |
|
[25] |
|
[26] |
|
[27] |
|
[28] |
|
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