Chinese General Practice ›› 2023, Vol. 26 ›› Issue (36): 4521-4526.DOI: 10.12114/j.issn.1007-9572.2023.0006
Special Issue: 心房颤动最新文章合集; 泌尿系统疾病最新文章合集
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Received:
2022-12-05
Revised:
2023-02-16
Published:
2023-12-20
Online:
2023-04-28
Contact:
HAN Quanle
通讯作者:
韩全乐
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0006
性别 | Scr(μmol/L) | eGFR〔mL·min-1·(1.73 m2)-1〕 |
---|---|---|
女性 | ≤62 | 144×(Scr/62)-0.329×(0.993)年龄 |
>62 | 144×(Scr/62)-1.209×(0.993)年龄 | |
男性 | ≤80 | 141×(Scr/80)-0.411×(0.993)年龄 |
>80 | 141×(Scr/80)-1.209×(0.993)年龄 |
Table 1 eGFR calculation formula
性别 | Scr(μmol/L) | eGFR〔mL·min-1·(1.73 m2)-1〕 |
---|---|---|
女性 | ≤62 | 144×(Scr/62)-0.329×(0.993)年龄 |
>62 | 144×(Scr/62)-1.209×(0.993)年龄 | |
男性 | ≤80 | 141×(Scr/80)-0.411×(0.993)年龄 |
>80 | 141×(Scr/80)-1.209×(0.993)年龄 |
组别 | 人数 | 年龄(岁) | 性别(男/女) | SBP (mmHg) | DBP (mmHg) | BMI (kg/m2) | 受教育程度〔名(%)〕 | 吸烟〔名(%)〕 | 饮酒〔名(%)〕 | 参加体育锻炼〔名(%)〕 | |
---|---|---|---|---|---|---|---|---|---|---|---|
高中以下 | 高中及以上 | ||||||||||
非心房颤动组 | 110 487 | 49.0±12.9 | 88 288/22 199 | 128±20 | 83±12 | 24.8±3.5 | 82 092(74.30) | 28 395(25.70) | 40 768(36.90) | 44 130(39.94) | 95 865(86.77) |
心房颤动组 | 368 | 63.4±10.6 | 338/30 | 135±21 | 85±12 | 25.3±3.7 | 311(84.51) | 57(15.49) | 123(33.42) | 124(33.70) | 342(92.93) |
统计检验量值 | 455.65a | 32.61 | 37.21a | 14.23a | 7.13a | 20.03 | 1.90 | 5.96 | 12.17 | ||
P值 | <0.001 | <0.001 | <0.001 | <0.001 | 0.007 | <0.001 | 0.168 | 0.015 | 0.001 | ||
组别 | 高血压〔名(%)〕 | 糖尿病〔名(%)〕 | 服用降压药〔名(%)〕 | 服用降糖药〔名(%)〕 | 服用降脂药〔名(%)〕 | TC (mmol/L) | TG〔M(P25,P75),mmol/L〕 | LDL-C (mmol/L) | HDL-C (mmol/L) | FPG (mmol/L) | hs-CRP〔M(P25,P75),mmol/L〕 |
非心房颤动组 | 42 946(38.87) | 8 562(7.75) | 9 123(8.26) | 2 027(1.83) | 645(0.58) | 4.92±1.05 | 1.24(0.86,1.89) | 2.38±0.89 | 1.51±0.39 | 5.42±1.48 | 0.97(0.38,2.65) |
心房颤动组 | 200(54.35) | 40(10.87) | 62(16.85) | 12(3.26) | 5(1.36) | 4.70±1.10 | 1.13(0.83,1.61) | 2.21±1.05 | 1.52±0.39 | 5.41±1.37 | 1.70(0.60,4.37) |
检验统计量值 | 36.97 | 4.99 | 35.61 | 4.13 | 3.78 | 15.98a | 14.68b | 13.80a | 0.07a | 0.01a | 35.85b |
P值 | <0.001 | 0.026 | <0.001 | 0.042 | 0.052 | <0.001 | <0.001 | <0.001 | 0.789 | 0.923 | <0.001 |
Table 2 Comparison of basic clinical characteristics of the study subjects
组别 | 人数 | 年龄(岁) | 性别(男/女) | SBP (mmHg) | DBP (mmHg) | BMI (kg/m2) | 受教育程度〔名(%)〕 | 吸烟〔名(%)〕 | 饮酒〔名(%)〕 | 参加体育锻炼〔名(%)〕 | |
---|---|---|---|---|---|---|---|---|---|---|---|
高中以下 | 高中及以上 | ||||||||||
非心房颤动组 | 110 487 | 49.0±12.9 | 88 288/22 199 | 128±20 | 83±12 | 24.8±3.5 | 82 092(74.30) | 28 395(25.70) | 40 768(36.90) | 44 130(39.94) | 95 865(86.77) |
心房颤动组 | 368 | 63.4±10.6 | 338/30 | 135±21 | 85±12 | 25.3±3.7 | 311(84.51) | 57(15.49) | 123(33.42) | 124(33.70) | 342(92.93) |
统计检验量值 | 455.65a | 32.61 | 37.21a | 14.23a | 7.13a | 20.03 | 1.90 | 5.96 | 12.17 | ||
P值 | <0.001 | <0.001 | <0.001 | <0.001 | 0.007 | <0.001 | 0.168 | 0.015 | 0.001 | ||
组别 | 高血压〔名(%)〕 | 糖尿病〔名(%)〕 | 服用降压药〔名(%)〕 | 服用降糖药〔名(%)〕 | 服用降脂药〔名(%)〕 | TC (mmol/L) | TG〔M(P25,P75),mmol/L〕 | LDL-C (mmol/L) | HDL-C (mmol/L) | FPG (mmol/L) | hs-CRP〔M(P25,P75),mmol/L〕 |
非心房颤动组 | 42 946(38.87) | 8 562(7.75) | 9 123(8.26) | 2 027(1.83) | 645(0.58) | 4.92±1.05 | 1.24(0.86,1.89) | 2.38±0.89 | 1.51±0.39 | 5.42±1.48 | 0.97(0.38,2.65) |
心房颤动组 | 200(54.35) | 40(10.87) | 62(16.85) | 12(3.26) | 5(1.36) | 4.70±1.10 | 1.13(0.83,1.61) | 2.21±1.05 | 1.52±0.39 | 5.41±1.37 | 1.70(0.60,4.37) |
检验统计量值 | 36.97 | 4.99 | 35.61 | 4.13 | 3.78 | 15.98a | 14.68b | 13.80a | 0.07a | 0.01a | 35.85b |
P值 | <0.001 | 0.026 | <0.001 | 0.042 | 0.052 | <0.001 | <0.001 | <0.001 | 0.789 | 0.923 | <0.001 |
组别 | 人数 | 新发CKD〔例(%)〕 | 累积发病率(%) |
---|---|---|---|
非心房颤动组 | 110 487 | 22 725(20.57) | 21.77 |
心房颤动组 | 368 | 95(25.82) | 30.40 |
χ2值 | 6.18a | 14.30b | |
P值 | 0.003 | <0.001 |
Table 3 Comparison of the incidence of new-onset CKD between the non-AFgroup and AF group
组别 | 人数 | 新发CKD〔例(%)〕 | 累积发病率(%) |
---|---|---|---|
非心房颤动组 | 110 487 | 22 725(20.57) | 21.77 |
心房颤动组 | 368 | 95(25.82) | 30.40 |
χ2值 | 6.18a | 14.30b | |
P值 | 0.003 | <0.001 |
组别 | 人数 | 新发CKD〔例(%)〕 | 累积发病率(%) |
---|---|---|---|
非心房颤动组 | 99 023 | 19 598(19.79) | 20.79 |
心房颤动组 | 199 | 56(28.14) | 30.48 |
χ2值 | 8.72a | 11.41b | |
P值 | 0.001 | 0.001 |
Table 4 Comparison of the incidence of new-onset CKD between the non-AF group and the AF groupin subjects aged≤65 years
组别 | 人数 | 新发CKD〔例(%)〕 | 累积发病率(%) |
---|---|---|---|
非心房颤动组 | 99 023 | 19 598(19.79) | 20.79 |
心房颤动组 | 199 | 56(28.14) | 30.48 |
χ2值 | 8.72a | 11.41b | |
P值 | 0.001 | 0.001 |
组别 | 人数 | 新发CKD〔例(%)〕 | 累积发病率(%) |
---|---|---|---|
非心房颤动组 | 11 464 | 3 127(27.28) | 31.32 |
心房颤动组 | 169 | 39(23.08) | 30.08 |
χ2值 | 1.48a | 0.04b | |
P值 | 0.034 | 0.848 |
Table 5 Comparison of the incidence of new-onset CKD between the non-AF group and the AF group in subjects aged>65 years
组别 | 人数 | 新发CKD〔例(%)〕 | 累积发病率(%) |
---|---|---|---|
非心房颤动组 | 11 464 | 3 127(27.28) | 31.32 |
心房颤动组 | 169 | 39(23.08) | 30.08 |
χ2值 | 1.48a | 0.04b | |
P值 | 0.034 | 0.848 |
Figure 3 Survival curves of the cumulative incidence of new-onset CKD in the atrial fibrillation group and the non-atrial fibrillation group aged>65 years
变量 | 模型一 | 模型二 | 模型三 | |||
---|---|---|---|---|---|---|
HR(95%CI) | P值 | HR(95% CI) | P值 | HR(95% CI) | P值 | |
全人群 | ||||||
非心房颤动 | 1.000 | 1.000 | 1.000 | |||
心房颤动 | 1.477(1.208,1.806) | <0.001 | 1.167(0.954,1.428) | 0.133 | 1.175(0.960,1.438) | 0.118 |
≤65岁人群 | ||||||
非心房颤动 | 1.000 | 1.000 | 1.000 | |||
心房颤动 | 1.566(1.204,2.035) | 0.001 | 1.363(1.048,1.769) | 0.021 | 1.350(1.038,1.755) | 0.025 |
>65岁人群 | ||||||
非心房颤动 | 1.000 | 1.000 | 1.000 | |||
心房颤动 | 0.970(0.707,1.330) | 0.855 | 1.007(0.734,1.381) | 0.968 | 0.999(0.728,1.371) | 0.996 |
Table 6 Multivariate Cox proportional risk regression model analysis of the effect of AF on the risk of new-onset CKD
变量 | 模型一 | 模型二 | 模型三 | |||
---|---|---|---|---|---|---|
HR(95%CI) | P值 | HR(95% CI) | P值 | HR(95% CI) | P值 | |
全人群 | ||||||
非心房颤动 | 1.000 | 1.000 | 1.000 | |||
心房颤动 | 1.477(1.208,1.806) | <0.001 | 1.167(0.954,1.428) | 0.133 | 1.175(0.960,1.438) | 0.118 |
≤65岁人群 | ||||||
非心房颤动 | 1.000 | 1.000 | 1.000 | |||
心房颤动 | 1.566(1.204,2.035) | 0.001 | 1.363(1.048,1.769) | 0.021 | 1.350(1.038,1.755) | 0.025 |
>65岁人群 | ||||||
非心房颤动 | 1.000 | 1.000 | 1.000 | |||
心房颤动 | 0.970(0.707,1.330) | 0.855 | 1.007(0.734,1.381) | 0.968 | 0.999(0.728,1.371) | 0.996 |
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