Correlation of Markers of Inflammation and Endothelial Injury with Thrombosis in Left Atrium in Patients with Atria Fibrillation
1. Cardiovascular Ward 2, Affiliated Hospital of Guilin Medical University, Guilin 541001, China 2. Cardiovascular Department, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China 3. Geriatric Cardiology Department, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
LI J Y, LIANG G C, WANG S R, et al. Correlation of markers of inflammation and endothelial injury with thrombosis in left atrium in patients with atria fibrillation [J]. Chinese General Practice, 2022, 25 (32) : 4018-4022.
LI Jinyi,LIANG Guicheng,WANG Shirong, et al. Correlation of Markers of Inflammation and Endothelial Injury with Thrombosis in Left Atrium in Patients with Atria Fibrillation[J]. Chinese General Practice, 2022, 25(32): 4018-4022. DOI: 10.12114/j.issn.1007-9572.2022.0490.
李金轶,梁桂琤,王世荣等. 心房颤动患者左心房血清炎性因子和血管内皮损伤标志物水平变化与血栓的相关性研究[J]. 中国全科医学, 2022, 25(32): 4018-4022. DOI: 10.12114/j.issn.1007-9572.2022.0490.
Table 1 Baseline characteristics of sinus rhythm patients,AF patients with and without left atrial appendage thrombus
组别
例数
年龄(岁)
性别(男/女)
BMI(kg/m2)
吸烟〔n(%)〕
糖尿病〔n(%)〕
高血压〔n(%)〕
LAD(mm)
LEF(%)
窦性心律组
15
58.9±7.2
10/5
21.1±0.9
7(46.7)
4(36.4)
10(66.7)
37.2±3.9
61.5±2.3
房颤无左心耳血栓亚组
12
64.1±5.3
9/3
21.0±1.0
7(58.3)
3(25.0)
10(83.3)
41.0±4.9
58.3±6.3
房颤+左心耳血栓亚组
12
60.9±7.0
9/3
21.6±1.0
6(58.3)
2(16.7)
8(66.7)
43.6±5.3
55.1±6.1
F(χ2)值
2.098
0.317a
1.330
1.381a
4.117a
1.140a
6.419
4.214
P值
0.137
0.854
0.273
0.501
0.814
0.566
0.004
0.023
Table 2 Levels of markers of inflammation and endothelial injury in left atrium in sinus rhythm patients,AF with and without left atrial appendage thrombus
Table 2 Levels of markers of inflammation and endothelial injury in left atrium in sinus rhythm patients,AF with and without left atrial appendage thrombus
组别
例数
AKt(μmol/L)
NF-κB(mg/L)
hs-CRP(mg/L)
IL-6(ng/L)
IL-8(ng/L)
TNF-α(ng/L)
窦性心律组
15
0.18±0.05
0.18±0.06
2.43±0.68
3.03±0.52
8.05±0.85
7.87±1.33
房颤无左心耳血栓亚组
12
0.35±0.10a
0.26±0.07a
2.85±0.48
2.98±0.54
9.00±1.02a
8.08±1.15
房颤+左心耳血栓亚组
12
0.44±0.09b
0.31±0.10
3.25±0.38b
3.32±0.53
9.10±1.00
8.19±1.58
F值
34.680
10.150
7.730
1.446
5.123
0.192
P值
<0.001
<0.001
0.002
0.249
0.011
0.826
组别
ET-1(ng/L)
NO(μmol/L)
vWF(%)
ICAM-1(mg/L)
VCAM-1(mg/L)
血栓面积(cm2)
窦性心律组
61.81±4.87
64.57±4.40
155.6±35.3
162.3±21.1
429.7±41.7
—
房颤无左心耳血栓亚组
68.77±7.17a
57.67±4.22a
148.4±38.2
232.9±38.6a
606.2±71.4a
—
房颤+左心耳血栓亚组
73.02±3.84
52.93±6.48b
154.1±34.2
248.5±43.8
654.1±78.2
3.48±0.83
F值
14.800
18.040
0.143
23.910
46.860
—
P值
<0.001
<0.001
0.867
<0.001
<0.001
—
Table 3 Correlation analysis of cardiac,inflammatory,and endothelial injury markers with the area of the left atrial appendage thrombus
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