Chinese General Practice ›› 2023, Vol. 26 ›› Issue (03): 367-371.DOI: 10.12114/j.issn.1007-9572.2022.0186
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Received:
2022-03-04
Revised:
2022-05-11
Published:
2023-01-20
Online:
2022-06-30
Contact:
NING Zong
About author:
通讯作者:
宁宗
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0186
调节机制 | 代表化合物 | |
---|---|---|
激动剂 | 抑制Xc-系统 | Erastin及其衍生物[ |
抑制/降解谷胱甘肽过氧化物酶4 | RSL3及其衍生物[ | |
其他 | FINO2[ | |
拮抗剂 | 抑制铁积累 | 环吡酮胺[ |
抑制酯质过氧化 | 齐留通,铁死亡抑制蛋白1[ | |
其他 | 七氟醚[ |
Table 1 Agonists and Antagonists of Ferroptosis and their Regulatory Mechanisms
调节机制 | 代表化合物 | |
---|---|---|
激动剂 | 抑制Xc-系统 | Erastin及其衍生物[ |
抑制/降解谷胱甘肽过氧化物酶4 | RSL3及其衍生物[ | |
其他 | FINO2[ | |
拮抗剂 | 抑制铁积累 | 环吡酮胺[ |
抑制酯质过氧化 | 齐留通,铁死亡抑制蛋白1[ | |
其他 | 七氟醚[ |
ALI模型 | 铁死亡抑制剂 | 作用靶点 | 信号通路 |
---|---|---|---|
肺缺血再灌注损伤模型 | iASPP、Lip-1 | Nrf2、ACSL4 | Nrf2/HIF-1α/TF |
脓毒症相关肺损伤模型 | Fer-1 | Nrf2 | Nrf2/HO-1/SLC7A11、Keap1/Nrf2/ARE |
放射性肺损伤模型 | Lip-1 | GPX4 | — |
淹溺致ALI模型 | Fer-1 | Nrf2 | — |
油酸致ALI模型 | — | PTGS2 | — |
Table 2 Relationship between ALI model and ferroptosis
ALI模型 | 铁死亡抑制剂 | 作用靶点 | 信号通路 |
---|---|---|---|
肺缺血再灌注损伤模型 | iASPP、Lip-1 | Nrf2、ACSL4 | Nrf2/HIF-1α/TF |
脓毒症相关肺损伤模型 | Fer-1 | Nrf2 | Nrf2/HO-1/SLC7A11、Keap1/Nrf2/ARE |
放射性肺损伤模型 | Lip-1 | GPX4 | — |
淹溺致ALI模型 | Fer-1 | Nrf2 | — |
油酸致ALI模型 | — | PTGS2 | — |
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