Novel Advances in Regulatory Mechanism of Microglia Autophagy，Inflammation and Their Interaction in Intracerebral Hemorrhage

doi:10.12114/j.issn.1007-9572.2020.00.467

Abstract

Abstract: Intracerebral hemorrhage has a higher incidence in middle-aged and elderly people，and has posed a major health threat to this population.Second only to cerebral infraction in morbidity，intracerebral hemorrhage is the second most common type of stroke，and its proportion in stroke is significantly higher in China than that in developed western countries.Intracerebral hemorrhage has placed a heavy burden on Chinese society，which has been in population aging，as well as on patients' families.To date，few therapeutic approaches with established efficacy for intracerebral hemorrhage have been available clinically.As the primary phagocytes in the brain，microglias play important roles in post-intracerebral hemorrhage brain injury，e.g.，protecting the central nervous system and alleviating brain injury through autophagy and modulating the inflammatory process.This paper reviews the roles of microglia autophagy and inflammation as well as their interactions in regulating intracerebral hemorrhage，expects to provide reference for the diagnosis and treatment of intracerebral hemorrhage，the identification of new therapeutic targets，as well as the improvement of prognosis.

Key words:
Intracerebral hemorrhage, Microglia, Autophagy, NLRP3 inflammasome, Inflammation, Review

摘要： 脑出血好发于中老年人，对中老年人健康威胁极大。我国脑出血发病率仅次于脑梗死，是第二大脑卒中类型，且脑出血患者在脑卒中患者中所占比例远高于西方发达国家，这对已步入老龄化的中国社会及患者家庭造成了沉重的负担。目前，临床尚缺乏确切有效的脑出血治疗手段。作为大脑组织的主要吞噬细胞，小胶质细胞在脑出血后脑损伤过程中发挥着重要作用，如通过自噬及调节炎症发挥中枢神经系统保护作用、减轻脑损伤等。本文综述了小胶质细胞自噬和炎症及其交互作用对脑出血的调控机制，旨在为脑出血的诊疗、新治疗靶点的发现及预后改善等提供参考。

关键词: 脑出血, 小神经胶质细胞, 自噬, 核苷酸结合寡聚化结构域样受体蛋白3炎性小体, 炎症, 综述

YAO LIN,MU Qiong. Novel Advances in Regulatory Mechanism of Microglia Autophagy，Inflammation and Their Interaction in Intracerebral Hemorrhage　[J]. Chinese General Practice, 2020, 23(30): 3888-3894. DOI: 10.12114/j.issn.1007-9572.2020.00.467.
姚林,穆琼. 小胶质细胞自噬和炎症及其交互作用对脑出血调控机制的研究进展[J]. 中国全科医学, 2020, 23(30): 3888-3894. DOI: 10.12114/j.issn.1007-9572.2020.00.467.

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