Abstract: Background　Primary liver cancer（PLC） is a malignant tumor with high mortality.Hepatic hemangioma（HH） is the most common benign tumor of liver.As the sensitivity and specificity of conventional ultrasound are low，and the contrast-enhanced ultrasound is invasive and its operation is complex，better examination methods for differentiating between PLC and HH are urgently needed.Objective　To discuss the application of sound speed correction（SSC） technique in the differential diagnosis of PLC from HH.Methods　We enrolled 85 eligible patients with solid liver masses（totaled 92 masses） from North China University of Science and Technology Affiliated Hospital from November 2016 to November 2017.According to the pathological results of the biopsy tissue or surgical specimen，39（totaled 44 masses were identified to be PLC） were assigned to the PLC group and 46（totaled 48 masses were identified to be HH） were assigned to the HH group，respectively.All of them underwent color Doppler ultrasound for the determination of the zone speed index（ZSI） of the ROI with SSC technique（for enhancing the quality of the images）.Results　The ZSI value of the masses of the PLC group was greater than that of the masses of the HH group〔（43.0±7.4）m/s vs （22.3±7.4）m/s〕（t=13.303，P<0.001）.For the diagnosis of PLC，the AUC of ZSI was 0.987（>0.700）when the cutoff value was 33 m/s，the corresponding sensitivity was 97.7%，specificity was 91.7%，and Youden's index was 0.894.Conclusion　When the ZSI value is 33 m/s（determined by the color Doppler ultrasound examination with SSC technique），both the sensitivity and specificity of its performance for differential diagnosis of PLC from HH are high，providing a reference for quantitatively differentiating between the two diseases.

Key words: Liver neoplasms, Hemangioma, Sound speed correction, Zone speed index, Ultrasonography

摘要： 背景　原发性肝癌为致死率高的肝脏恶性肿瘤，肝血管瘤为最常见的肝脏良性肿瘤，而常规超声检查的灵敏度和特异度较低，超声造影操作复杂且有创，因此探寻新型的检查方法是大势所趋。目的　探讨声速匹配（SSC）技术在原发性肝癌与肝血管瘤鉴别诊断中的应用价值。方法　选取2016年11月—2017年11月就诊于华北理工大学附属医院的符合研究标准的肝脏实性肿物患者85例，肿物92个（原发性肝癌44个、肝血管瘤48个）。依据穿刺或手术病理结果将患者分为原发性肝癌组（n=39）和肝血管瘤组（n=46）。患者均进行SSC检查，分析肝脏肿物的区域速度指数（ZSI）值鉴别诊断原发性肝癌与肝血管瘤的价值。结果　原发性肝癌组44个肿物的ZSI值为（43.0±7.4）m/s，肝血管瘤组48个肿物的ZSI值为（22.3±7.4）m/s；原发性肝癌组肿物的ZSI值高于肝血管瘤组（t=13.303，P<0.001）。绘制ZSI值诊断原发性肝癌的ROC曲线，当ZSI=33 m/s时，ZSI值诊断原发性肝癌的ROC曲线下面积为0.987（>0.700），灵敏度为97.7%，特异度为91.7%，约登指数为0.894。结论　当ZSI=33 m/s时，SSC鉴别诊断原发性肝癌与肝血管瘤的灵敏度、特异度均较高，可为超声鉴别原发性肝癌与肝血管瘤提供新的量化诊断参考指标。

关键词: 肝癌, 血管瘤, 声速匹配, 区域速度指数, 超声检查