更多内容请点击

中国全科医学 ›› 2021, Vol. 24 ›› Issue (33): 4229-4233.DOI: 10.12114/j.issn.1007-9572.2021.02.032

所属专题： 内分泌代谢性疾病最新文章合集

• 专题研究 • 上一篇    下一篇

血清成纤维细胞生长因子21水平与糖尿病周围神经病变的相关性研究

李勇1，2，齐丽翠2，3，张然1，2，杨琦雯2，3，陈树春2*   

  1. 1.063210河北省唐山市，华北理工大学研究生院　2.050051河北省石家庄市，河北省人民医院内分泌科　3.075000河北省张家口市，河北北方学院研究生院
    *通信作者：陈树春，主任医师；E-mail：guang6701@sina.com
  • 出版日期:2021-11-20 发布日期:2021-11-20
  • 基金资助:
    中央引导地方科技发展资金项目（206Z7702G）

Correlation between Serum FGF21 Level and Diabetic Peripheral Neuropathy　

LI Yong1，2，QI Licui2，3，ZHANG Ran1，2，YANG Qiwen2，3，CHEN Shuchun2*   

  1. 1.Graduate School of North China University of Science and Technology，Tangshan 063210，China
    2.Department of Endocrinology，Hebei General Hospital，Shijiazhuang 050051，China
    3.Graduate School，Hebei North University，Zhangjiakou 075000，China
    *Corresponding author：CHEN Shuchun，Chief physician；E-mail：guang6701@sina.com
  • Published:2021-11-20 Online:2021-11-20

RichHTML

PDF
分享到

摘要： 背景　成纤维细胞生长因子21（FGF21）是一种多效内分泌代谢调节因子，可通过抑制氧化应激和炎性反应促进小鼠周围神经轴突和髓鞘的再生。然而有关人体中FGF21与糖尿病周围神经病变（DPN）的相关性研究甚少，且作用机制尚不明确。目的　探讨血清FGF21水平与DPN的相关性。方法　选取2019年11月至2020年11月于河北省人民医院就诊的200例2型糖尿病（T2DM）患者为研究对象，根据是否合并DPN将其分为糖尿病周围神经病变组（DPN组）109例和非糖尿病周围神经病变组（NDPN组）91例。采用酶联免疫吸附试验（ELISA）检测两组患者血清FGF21水平并收集其临床资料。采用Pearson相关分析和Spearman秩相关分析探究血清FGF21水平与各指标的相关性，二元Logistic回归分析探究T2DM患者发生DPN的影响因素。结果　DPN组血清FGF21水平高于NDPN组（P<0.05）。相关性分析结果显示，T2DM患者FGF21与空腹血糖（FPG）、糖化血红蛋白（HbA1c）、丙二醛（MDA）、肿瘤坏死因子α（TNF-α）呈正相关（r=0.184、r=0.156、rs=0.164、r=0.175，P<0.05），与超氧化物歧化酶（SOD）呈负相关（r=-0.189，P<0.05）。二元Logistic回归分析结果显示，糖尿病病程〔OR=1.499，95%CI（1.085，1.935）〕、MDA〔OR=1.242，95%CI（1.062，1.452）〕、TNF-α〔OR=1.036，95%CI（1.012，1.060）〕和FGF21〔OR=1.007，95%CI（1.002，1.012）〕是T2DM患者发生DPN的独立影响因素（P<0.05）。结论　FGF21是T2DM患者发生DPN的独立影响因素，其可通过调节糖代谢、抑制氧化应激和炎性反应对DPN的发生产生影响。

关键词: 糖尿病, 2型；糖尿病周围神经病变；成纤维细胞生长因子21；超氧化物歧化酶；丙二醛；肿瘤坏死因子α

Abstract: Background　Fibroblast growth factor 21 （FGF21） is a pleiotropic endocrine metabolism regulator，which can facilitate the regeneration of peripheral nerve axons and myelin sheaths in mice by inhibiting oxidative stress and inflammation. However，there are few studies on the correlation between FGF21 and diabetic peripheral neuropathy （DPN） in humans，and the mechanism of action is still unclear. Objective　To explore the correlation between serum FGF21 level and DPN. Methods　A total of 200 patients with type 2 diabetes were recruited from Hebei General Hospital from November 2019 to November 2020，including 109 with DPN and 91 without. Serum FGF21 was detected using ELISA，and other clinical data were collected. Pearson and Spearman rank correlation analysis was used to examine the correlation between serum FGF21 and various indicators. Binary Logistic regression analysis was performed to identify the influencing factors of DPN in type 2 diabetes. Results　The average serum FGF21 in patients with DPN was significantly higher than that in those without （P<0.05）. Correlation analysis showed that FGF21 was positively correlated with fasting plasma glucose，glycosylated hemoglobin，malondialdehyde，and TNF-α （r=0.184，r=0.156，rs=0.164，r=0.175，P<0.05），and was negatively correlated with the superoxide dismutase （r=-0.189，P<0.05）. Binary Logistic regression analysis showed that course of type 2 diabetes〔OR=1.499，95%CI（1.085，1.935）〕，malondialdehyde〔OR=1.242，95%CI（1.062，1.452）〕，TNF-α〔OR=1.036，95%CI（1.012，1.060）〕 and FGF21〔OR=1.007，95%CI（1.002，1.012）〕 were independent influencing factors for DPN in type 2 diabetes （P<0.05）. Conclusion　FGF21 is an independent influencing factor of DPN in type 2 diabetes，which can affect DPN by regulating glucose metabolism，inhibiting oxidative stress and inflammation.

Key words: Diabetes mellitus, type 2；Diabetic peripheral neuropathies；Fibroblast growth factor 21；Superoxide dismutase；Malondialdehyde；Tumor necrosis factor-alpha

冀ICP备12018774号-6　冀公网安备 13040302001295号　网站版权 © 《中国全科医学》编辑部　技术支持：北京玛格泰克科技发展有限公司