关键词: 糖尿病, 胰岛素, 针头, 重复使用, 脂肪增生

Abstract: Background　Lipohypertrophy is a common complication of insulin injection in diabetic patients.Current studies have not been consistent on whether there is a relationship between repeated use of needles and the occurrence of lipohypertrophy，since the conception of "reuse" is too broad. Objective　The purpose of this study is to evaluate the relationship between use frequency of insulin needles and the occurrence of lipohypertrophy. Methods　From March to November，2018，databases of PubMed，Cochrane Library，EMBase，Science Direct，CMB，and CNKI were searched from inception to October 2018 for collecting epidemiological and experimental studies on the relationship between lipohypertrophy and times （1，2-3，4，5，6-10） of use of insulin injection needles. Quality evaluation and data extraction of the included studies were performed. Network meta-analysis was performed using Stata15.0. Results　Patients who did not reuse insulin injection needles had the lowest incidence of lipohypertrophy（10.1%）. There was no significant difference in the incidence of lipohypertrophy among patients reusing the needles 2-10 times（P>0.05）. The incidence of lipohypertrophy rose significantly in those reusing needles 6-10 times compared with that of those without reuse behaviors〔OR=3.72，95%CI（1.05，13.17），P<0.05〕. The incidence of lipohypertrophy was not significantly different across patients who used needles 1-5 times（P>0.05）. Conclusion　Disposable insulin needles are highly recommended. If such needles are not available due to limited medical resources or other factors，the times of reusing needles should not exceed 5.

Key words: Diabetes, Insulin, Needles, Reuse, Lipohypertrophy