关键词: 先兆子痫, 血小板, 凝血酶原时间, 活化部分凝血活酶时间, ROC曲线

Abstract: Background　Preeclampsia（PE）is a serious complication of pregnancy.The best cut-off values of coagulation function and platelet parameters can be used to screen for preeclampsia，but the interpretation of test results is often controversial.Objective　To explore the value of coagulation function and platelet parameters in the assistant diagnosis of preeclampsia and its severity.Methods　A total of 325 pregnant women delivered in the Second Hospital of Shanxi Medical University from May 2016 to September 2018 were selected as the study subjects，including 100 cases in the health group，46 cases in the gestational hypertension（GH）group，48 cases in the mild preeclampsia（mPE）group and 131 cases in the severe preeclampsia（sPE）group.The general clinical data，coagulation function indexes〔prothrombin time（PT），activated partial thromboplastin time（APTT），international normalized ratio（INR），fibrinogen（FIB）〕and platelet parameters〔platelet count（PLT），mean platelet volume（MPV），platelet distribution width（PDW），plateletcrit（PCT），platelet count/mean platelet volume（PLT/MPV）〕of four groups of pregnant women were compared.The ROC curve was used to analyze the assistant diagnostic value of coagulation function and platelet parameters for preeclampsia and its severity.Results　There were significant differences in the gestational weeks, the body mass index（BMI）, systolic blood pressure，diastolic blood pressure, neonatal body mass, blood coagulation function（PT，APTT，INR，FIR） and platelet parameters（PLT，MPV，PDW，PCT，PLT/MPV）between the four groups of pregnant women（P<0.05）.The results of ROC curve analysis showed that APTT，MPV，PDW have auxiliary diagnostic value for pre-eclampsia〔the area under ROC curve（AUC）were 0.61，0.63，0.66，respectively，P<0.05〕; APTT has auxiliary diagnostic value for pre-eclampsia severity （AUC=0.67，P<0.05），combined detection of APTT，PT，INR，FIB，PLT，MPV，PDW，PCT and PLT/MPV have a higher auxiliary diagnostic value for pre-eclampsia and its severity （AUC were 0.78, 0.75 respectively，P<0.05）. Conclusion　APTT，MPV and PDW are helpful in the diagnosis of pre-eclampsia，and APTT is helpful in the diagnosis of the severity of pre-eclampsia.APTT combined with other coagulation function indicators and platelet parameters is more helpful in the diagnosis of pre-eclampsia and its severity.

Key words: Pre-eclampsia, Blood platelents, Prothrombin time, Activated partial thromboplastin time, ROC curve