关键词: 关节炎, 类风湿；性别分布；伴随疾病；药物选择

Abstract: Objective　To explore concomitant disease and drug use in patients with rheumatoid arthritis （RA） in clinical practice between different genders，thus raising the awareness of patients with RA.Methods　A total of 15 353 patients admitted to Peking University People's Hospital were enrolled from September 2014 to September 2015.Their basic information，including gender，age，laboratory features and drug use were collected from clinical laboratory information system and electronic medical record system of Yidu Cloud Technology Company Ltd.Statistical analysis of concomitant disease and drug use were compared by chi-square test.Results　Among the subjects，4 002 were male （26.07%） and 11 351 female （73.93%），with a ratio of approximately 1∶2.8.The common concomitant rheumatic diseases in patients with RA were sjogren syndrome （SS，5.24%），systemic lupus erythematosus （SLE，2.53%），and ankylosing spondylitis （AS，1.07%）.Except for RA patients aged 65 years and over，the prevalence rates of SS and SLE in female patients with RA were higher than those in male （P<0.05），and of AS in male patients with RA was higher than that in female （P<0.05）.Other concomitant diseases were osteoarthritis （37.56%），osteoporosis （33.37%），hypertension （29.87%），hyperlipidaemia （19.49%），coronary heart disease （19.16%），peptic ulcer （16.80%），cerebrovascular disease （13.59%），chronic gastritis （13.11%），diabetes （10.90%），and atherosclerosis （10.17%）.The significant difference was found on above-mentioned concomitant diseases （except chronic gastritis，cerebral vascular disease in patients aged 44 years or below and osteoarthritis，hyperlipidemia，cerebrovascular disease and atherosclerosis in patients aged 65 years and over） between female and male patients with RA in different ages （P<0.05）.The most common 10 kinds of drugs used in patients with RA were leflunomide （54.63%），methotrexate （26.20%），hydroxychloroquine sulfate （23.14%），diclofenac （22.20%），loxoprofen （21.20%），celecoxib （20.20%），total glucosides of paeony （18.52%），glucocorticoid （16.77%），meloxicam （15.90%） and sulfasalazine （13.75%）.The use of leflunomide was significantly higher in male patients than in female patients （P<0.05），while the use of methotrexate，hydroxychloroquine sulfate，glucocorticoid，and total glucosides of paeony were significantly higher in female patients （P<0.05）.Conclusion　The concomitant disease and drug of choice were significantly different between female and male patients with RA，which should be paid more attention to in clinics.

Key words: Arthritis, rheumatoid；Sex disribution；Concomitant disease；Drug of choice