关键词: 急性缺血性脑卒中, 首次运动康复治疗时间, 运动功能

Abstract: Objective　To investigate the effect of timing of initiating exercise rehabilitation on the prognosis of motor function in patients with acute ischemic stroke（AIS）.Methods　We enrolled 67 cases of AIS from Emergency Department and Neurology Ward，Shengjing Hospital of China Medical University from September 2015 to August 2017 and randomized them into group A（n=35），and group B（n=32，2 patients withdrew from the study），receiving an exercise rehabilitation initiated within 24-48 h，48-120 h，respectively after the onset of AIS.The intervention for both groups ended on the 90th day after the onset of AIS.Baseline characteristics were collected by reviewing the medical records.The motor function was evaluated by both Modified Rankin Scale （MRS） and Fugl-Meyer Assessment（FMA） on the 7th，14th，30th，60th，and 90th days after the onset of AIS，respectively.Results　Two groups showed no significant differences in baseline characteristics and the mean MRS score measured on the 7th day after the onset of AIS （P>0.05），but group A demonstrated a significantly decreased mean MRS score on the 90th day after the onset of AIS （P<0.05）.Although the overall mean upper extremity FMA score did not differ significantly between the groups（P>0.05），the mean upper extremity FMA score varied substantially between the groups at different times during the rehabilitation period （P<0.05），in particular，it was much higher in group A than that of group B at the end of the 7th day of rehabilitation （P<0.05）.The overall mean lower extremity FMA score and mean lower extremity FMA score at different times during the rehabilitation period differed significantly between the groups（P<0.05），to be specific，group A showed much higher mean lower extremity FMA score than group B at the end of the 7th，14th，30th，60th，and 90th days of rehabilitation （P<0.05）.In addition，the FMA scores for both the upper and lower extremities were not influenced obviously by the interaction effect of the timing of initiating exercise rehabilitation and duration of the rehabilitation （P>0.05）.Conclusion　For AIS patients with an MRS score of 3-4，exercise rehabilitation initiated within 48 h after the onset of AIS can significantly improve the motor function.

Key words: Acute ischemic stroke, Initial time of motor rehabilitation, Motor function