钙敏感受体在心肌损伤中介导的信号通路研究进展

doi:10.12114/j.issn.1007-9572.2024.0117

摘要/Abstract

摘要： 钙敏感受体（CaSR）是一种G蛋白偶联受体，可以诱导高度扩散的信使以激活各种细胞反应。最近研究认为CaSR介导内质网、线粒体、细胞核之间的信号通信，且此过程与心肌损伤相关。心肌细胞为永久细胞，不可再生。因此，本文将重点介绍CaSR在心肌损伤中的相关调控机制，梳理其介导的复杂细胞内信号转导网络，为寻找心肌损伤治疗新靶点提供思路。

关键词: 心肌损伤, 心肌肥大, 心肌纤维化, 钙敏感受体

Abstract:

Calcium sensing receptor (CaSR) is a G-protein-coupled receptor that induces highly diffused messengers to activate various cellular responses. Recently, it has been suggested that CaSR mediates signal communication among endoplasmic reticulum, mitochondria, and nucleus, and this process is associated with myocardial injury. Cardiomyocytes are permanent cells and do not regenerate. Therefore, this paper will focus on the relevant regulatory mechanisms of CaSR in myocardial injury, comb out the complex intracellular signal transduction network mediated by CASR, and provide ideas for finding new therapeutic targets for myocardial injury.

Key words: Myocardial injury, Myocardial hypertrophy, Myocardial fibrosis, Calcium sensitive receptors

中图分类号:

R 541

沈明妹,吕俞娇,张尚博,等. 钙敏感受体在心肌损伤中介导的信号通路研究进展[J]. 中国全科医学, 2025, 28(18): 2301-2306. DOI: 10.12114/j.issn.1007-9572.2024.0117.
SHEN Mingmei,LYU Yujiao,ZHANG Shangbo, et al. Calcium Sensitive Receptors Mediate Signaling Pathways in Myocardial Injury[J]. Chinese General Practice, 2025, 28(18): 2301-2306. DOI: 10.12114/j.issn.1007-9572.2024.0117.

图/表 2

表1 CaSR所介导的信号通路参与心肌损伤疾病的类型

Table 1 The signaling pathway mediated by CaSR is involved in the types of myocardial injury diseases

	缺血再灌注	急性心肌梗死	高血压（心肌肥大）	糖尿病心肌病（心肌纤维化）
PKC-δ易位	+	+
CaN/NFAT	+		+
TGF-β1/Smads				+
CaSR/Wnt/β-catenin				+
NF-κB	+	+	+

图1 CaSR参与心肌损伤所介导的信号通路注：CaSR=钙敏感受体，PKC-δ=蛋白激酶Cδ，Bad=B细胞淋巴瘤-2相关死亡启动因子，P=磷酸化，NLRP3=炎症小体，Caspase-1=半胱氨酸天冬氨酸蛋白水解酶1，proCaspase-1=半胱氨酸天冬氨酸蛋白水解酶前体，IL-1β=白介素1β，IL-18=白介素18，pro-IL-1β=白介素1β前体，pro-IL-18=白介素18前体，Gq/11为G蛋白的一种三聚体形式。

Figure 1 CaSR is involved in signaling pathways mediated by myocardial injury

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