Objective  To detect the level of plasma 6-Ketoprostaglandin F1α(6-K-PGF1α) of patients with coronary heart disease(CHD) combined with diabetes,and to investigate patients′ major adverse cardiovascular events(MACE) and occurrence of rehospitalization.

 Methods  270 CHD patients,who were in North China University of Science and Technology Affiliated Hospital from July 2013 to June 2014,were selected.According to whether combined with diabetes,patients were divided into group combined with diabetes(n=134) and group without diabetes(n=136).The clinical condition of the patients was recorded,height,weight,blood pressure,heart rate were measured,and examinations of electrocardiogram,echocardiography,and coronary angiography were carried out.Blood routine,blood clotting function,biochemical indicators were examined.6-K-PGF1α level of patients in two groups was detected.Follow-up lasted for one year,MACE events and rehospitalization situation of patients in two groups were recorded.

 Results  The comparison of gender,interventional treatment,age,BMI,systolic blood pressure,diastolic blood pressure,heart rate,number of coronary artery lesions,number of severe coronary lesions and levels of sensitivity C-reactive protein(hs-CRP),serum creatinine(SCr),uric acid(UA),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) between two groups were not significantly different(P＞0.05).The 6-K-PGF1α level of patients in group combined with diabetes were significantly lower than that in group without diabetes(P＜0.05).The number of coronary artery lesions,number of severe coronary lesions,hs-CRP level,systolic blood pressure presented a negative linear correlation with 6-K-PGF1α level(r value was-0.218,-0.155,-0.139,-0.120 respectively;P＜0.05).For group combined with diabetes,the number of coronary artery lesions,BMI,hs-CRP level,TC level showed a negative linear correlation with 6-K-PGF1α level(r value was-0.194,-0.179,-0.146,-0.126 respectively;P＜0.05);for group combined without diabetes,the number of coronary artery lesions,systolic pressure,hs-CRP level,number of severe coronary lesions manifested a negative linear correlation with 6-K-PGF1α level(r value was-0.241,-0.193,-0.176,-0.175 respectively;P＜0.05).The occurrence rates of MACE in two groups were not significantly different(P＞0.05);the rehospitalization rate of group combined with diabetes was significantly higher than that of group combined without diabetes(P＜0.05).

 Conclusion  The 6-K-PGF1α level of CHD patients with diabetes is lower,while the risk of hospitalization again is increased.Therefore,CHD patients combined with diabetes should further strengthen anti-platelet therapy and protect vascular endothelial function.