关键词: 带状疱疹, 临床特征, 他汀类药物

Abstract: Background　Herpes zoster is a common infectious disease caused by reactivation of varicella zoster virus.This disease may lead to papule blister，and may be accompanied by neuralgia，herpes zoster ophthalmicus，secondary infection，etc，seriously impairing the patient's quality of life.Statins are widely used in clinical practice as a lipid-regulating drug.Several studies have confirmed that herpes zoster is associated with the use of statins.Objective　To analyze the clinical characteristics of herpes zoster and to explore the relationship between herpes zoster and the use of statins.Methods　The enrolled 1 462 inpatients were all from the First Affiliated Hospital of Chongqing Medical University from November 2014 to November 2016，including 731 with herpes zoster（herpes zoster group），and 731 without herpes zoster（control group）．Demographic and clinical data，including gender，age，smoking history，drinking history，body mass index（BMI），lipid levels，comorbidities，and use of statins and antiplatelet aggregation drugs were collected.The prevalence of herpes zoster by gender and age，the relationship of herpes zoster with smoking and drinking history，BMI，lipid level，comorbidities，use of statins and antiplatelet agglutination drugs were analyzed.The herpes zoster patients were divided into≤ 30-year-old subgroup（49 cases），31-60-year-old subgroup（261 cases），and > 60-year-old subgroup（421 cases），then their characteristics were compared.Results　The use rate of statins in herpes zoster group was higher than that of the control group（P<0.05）．Among the herpes zoster patients，there were 446（61.0%） with comorbidities，including 228（51.1%） with multicomorbidities；the most common comorbidities were hypertension〔242 cases（54.3%）〕and diabetes〔134 cases（30.0%）〕.The prevalence of herpes zoster varied significantly by age subgroups（P<0.05）．Herpes zoster patients in > 60-year-old subgroup had higher use rate of statins，higher prevalence of hypertension cardiovascular diseases except hypertension as well as stroke compared with ≤30-year-old subgroup，31-60-year-old subgroup（P<0.05）．Herpes zoster patients in 31-60-year-old subgroup showed higher prevalence of diabetes compared with ≤30-year-old subgroup（P<0.05）．Herpes zoster patients in≤30-year-old subgroup demonstrated higher prevalence of tumor than the other two subgroups（P<0.05）．The prevalence of connective tissue disease was higher in 31-60-year-old subgroup compared with > 60-year-old subgroup，but lower than ≤30-year-old subgroup（P<0.05），and it was higher in≤30-year-old subgroup compared with > 60-year-old subgroup（P<0.05）．Conclusion　The prevalence of herpes zoster may be associated with older age and use of stains.

Key words: Herpes zoster, Clinical characteristics, Statins