关键词: 原因不明发热, 病因辨证, 回顾性研究

Abstract: Objective　To investigate the causes of fever of unknown origin（FUO），in order to benefit the clinical diagnosis and treatment of this disease.Methods　In this retrospectively study，we enrolled 372 cases of FUO according to the diagnostic criteria from Tangshan Gongren Hospital from July 2014 to June 2017.We collected their data about baseline characteristics，diagnostic methods，classification of causes of FUO and outcome.Results　The clinical data of these patients are as follows：distribution of sex：184 males and 188 females；mean age：（48.0±18.3） years；number of patients without identified causes of FUO：85（accounting for 22.8% of the total）；number，diagnostic pathway and classification of causes of FUO of patients with identified causes of FUO：287 were found with identified causes，accounting for 77.2% of the total，138（48.1%） by clinical features and/or treatment response；86（30.0%） of them were diagnosed by pathogenic or serological examination，50（17.4%） by imaging examination，and 13（4.5%） by pathological or bone marrow examination，181（63.1%） of them were caused by infectious disease〔121（66.9%） by bacterial infectious disease，and 60（33.1%） by viral infectious disease〕，57（19.9%） by connective tissue disease〔including 14（24.6%） by adult onset Still's disease〕，17（5.9%） by neoplastic disease〔including 10（58.8%） by hematological tumor〕，and 32（11.1%） by other diseases〔including 15（46.9%） by subacute thyroiditis〕．Conclusion　Infectious diseases，especially brucellosis and tuberculosis，were the most common causes of FUO．Furthermore，the characteristics of the region that the patient comes from，features of the hospital that the patient treated in，patient'atmedical history，results of meticulous physical check-up，clinical characteristics，results of auxiliary and invasive examinations are all contributive to the identification of the causes of FUO.

Key words: Fever of unknown origin, Syndrome differ pathogen fact, Retrospective studies