关键词: 中年人, 老年人, 代谢综合征X, 颈动脉, 斑块, 动脉粥样硬化, 性别因素

Abstract: Objective　To investigate correlation between metabolic syndrome and carotid plaque of middle-aged and aged people and its gender differences.Methods　Staffs （aged≥45） who participated in the physical examination for the first time in a company from June 2011 to December 2013 were stratified according to age groups of every 5 years,and 2 180 middle-aged and aged people were selected in proportion from each age group.According to inclusion and exclusion criteria,1 770 middle-aged and aged people were finally selected,813 were male and 957 were female （including 673 postmenopausal cases,284 non-menopause cases）.Carotid ultrasound was used to check whether there was plaque in carotid artery.The international unified standard in 2009 was applied by MS diagnosis （which abdominal obesity using Asian standards）.Results　Among 1 770 middle-aged and aged people,prevalence rate of MS was 40.3% （714/1 770）,detection rate of carotid artery plaque was 25.9% （459/1 770）.There was significant difference in the detection rate of carotid artery plaque among middle-aged and aged males and females and the total population with or without MS （P<0.05）.With the increasing number of components in MS,the detection rate of carotid artery plaque in middle-aged and aged men and women as well as the total population showed an increasing trend （P<0.001）.After adjustment of age,BMI,smoking index,low-density lipoprotein cholesterol （LDL-C）,total cholesterol （TC） and serum uric acid （SUA）,the detection risk of carotid artery plaque of middle-aged and aged men 〔OR（95%CI）=1.53（1.04,2.23）,P=0.030〕 and postmenopausal females 〔OR（95%CI）=1.60（1.08,2.38）,P=0.020〕 increased.Among middle-aged and aged men,blood pressure elevation 〔OR（95%CI）=1.65（1.14,2.37）,P=0.008〕 and blood glucose rising 〔OR（95%CI）=1.93（1.36,2.75）,P<0.001〕 were the components that had great influence on detecting carotid artery plaque after adjustment of age,BMI,smoking index,LDL-C,TC and SUA;among middle-aged and aged women,after adjusting age,BMI,smoking index,LDL-C,TC and SUA and menopause or not,the component that had great effect on detecting carotid artery plaque was blood pressure elevation 〔OR（95%CI）=1.82（1.25,2.65）,P=0.002〕.Conclusion　MS is an independent risk factor of detecting carotid artery plaque in middle-aged and aged men and postmenopausal women;the detection of carotid artery plaque among middle-aged and aged people of different genders was mainly influenced by different components of MS.

Key words: Middle aged, Aged, Metabolic syndrome X, Carotid arteries, Plaque,atherosclerotic, Sex factors