关键词: Meta流行病学研究, 中医药, 临床研究, 试验设计, 研究进展

Abstract: The contradiction between the highly individualized nature of traditional Chinese medicine (TCM) treatment and the rigors of research design represents one of the primary factors contributing to the scarcity of high-quality research within the realm of TCM. Thus, there is a pressing need for an effective instrument to precisely investigate the influence of research design variations or latent biases on research outcomes, thereby offering scientific guidance for TCM research design. Meta-epidemiological research is an important tool for identifying and quantifying the impact of potential bias characteristics. It can uncover potential issues in the design of TCM clinical trials and quantitatively evaluate the effects of relevant factors on research findings. By assessing the disparities between TCM research designs or novel research designs and standardized research designs, it is possible to provide reliable evidence-based insights into the developmental direction of TCM clinical research design.