关键词: 硫氧还蛋白质类, 高甘油三酯血症, 脂耐量减低, 口服脂肪耐量试验, 硫氧还蛋白相互作用蛋白

Abstract: Background　There is a long-term link between elevated triglyceride （TG） levels and cardiovascular diseases.In patients receiving statin therapy and with LDL-C levels well controlled，those with elevated TG levels still have a higher risk of developing atherosclerotic cardiovascular disease than those with lower TG levels.Therefore，the early detection of factors related to the progression of HTG is essential for ASCVC prevention and treatment. And thioredoxin-interacting protein（TXNIP）plays a crucial role in lipid metabolism.Objective To evaluate the association of serum TXNIP levels with impaired fat tolerance（IFT） and hypertriglyceridemia（HTG）. Methods　A total of 235 volunteers with different fat tolerances were selected for the oral fat tolerance test（OFTT）. According to the OFTT results，the subjects were divided into a normal fat tolerance group（NFT group，75 cases），an IFT group （85 cases），and an HTG group （75 cases）. The subjects were divided into Q1-Q4 groups according to the serum triglyceride（TG） quartile. Measure fasting blood glucose （FBG），2-hour postprandial blood glucose after oral glucose tolerance test（OGTT），fasting insulin（FINS），serum uric acid（SUA），apolipoprotein A1（ApoA1），apolipoprotein B（ApoB），and total cholesterol（TC），triglycerides（TG），high-density lipoprotein cholesterol（HDL-C），low-density lipoprotein cholesterol （LDL-C） at fasting and 4 hours after high-fat meals . Calculate non-HDL-C and triglyceride-rich lipoprotein remnants （TRLRs）. Evaluate the homeostasis model assessment of insulin resistance （HOMA-IR） and the homeostasis model assessment of beta-cell function（HOMA-β）. Measure serum TXNIP with an enzyme-linked immunosorbent assay （ELISA） and analyze the correlation between TXNIP and each indicator. Calculate non-HDL-C and triglyceride-rich lipoprotein remnants （TRLRs）. Evaluate the homeostasis model assessment of insulin resistance（HOMA-IR） and the homeostasis model assessment of beta-cell function（HOMA-β）. Measure serum TXNIP with an enzyme-linked immunosorbent assay （ELISA） and analyze the correlation between TXNIP and each indicator. Results　The serum TXNIP levels in the IFT group and the HTG group were higher than those in the NFT group，and the HTG group was higher than the IFT group. The levels of TXNIP in groups Q2，Q3 and Q4 were higher than those in group Q1. The levels of TXNIP in groups Q3 and Q4 were higher than those in group Q2，and the level of TXNIP in group Q4 was higher than that in group Q3. Serum TXNIP levels were positively correlated with SUA，FBG，FINS，HOMA-IR，HOMA-β，0 h TC，4 h TC，0 h TG，4 h TG，0 h LDL-C，4 h LDL-C，Non-HDL-C，TRLRs，and ApoB，and negatively correlated with 0 h HDL-C and 4 h HDL-C （P<0.05）.After adjusting for major confounders，multiple linear regression analysis showed that IFT and HTG were significantly correlated with TXNIP levels（IFT：β=0.184，P=0.006；HTG：β=0.441，P<0.001）. Conclusion　Serum TXNIP levels were positively correlated with the degree of impaired fat tolerance，and decreasing serum TXNIP levels may delay the progression of HTG-related diseases.

Key words: Thioredoxins, Hypertriglyceridemia, Impaired lipid tolerance, Oral fat tolerance test, Thioredoxin-interacting protein