中国全科医学 ›› 2024, Vol. 27 ›› Issue (19): 2357-2363.DOI: 10.12114/j.issn.1007-9572.2023.0712

• 论著 • 上一篇    下一篇

65岁及以上老年人群中基于脂肪组织过多引起的慢性疾病患病情况及影响因素分析

廖艳萍1,2, 李云意2, 周志衡3, 王皓翔2,*()   

  1. 1.518122 广东省深圳市坪山区妇幼保健院病案管理科
    2.510080 广东省广州市,中山大学公共卫生学院
    3.518118 广东省深圳市,南方医科大学坪山总医院科教部
  • 收稿日期:2023-08-31 修回日期:2024-03-24 出版日期:2024-07-05 发布日期:2024-04-28
  • 通讯作者: 王皓翔

  • 作者贡献:

    廖艳萍应用统计软件分析数据,进行论文撰写;王皓翔提出研究思路,对论文质量进行校正,对文章整体负责;周志衡收集数据,并对数据分析进行指导;李云意协助分析数据。

  • 基金资助:
    国家自然科学基金-组织间国际合作研究项目(72061137002); 深圳市科技计划项目(JCYJ20210324135411031); 坪山区卫生健康系统科研项目(202289)

Prevalence and Root Cause Analysis of Adiposity-based Chronic Disease in Older Adults Aged 65 Years and Older

LIAO Yanping1,2, LI Yunyi2, ZHOU Zhiheng3, WANG Haoxiang2,*()   

  1. 1. Case Management Section, Shenzhen Pingshan District Maternal and Child Health Care Hospital, Shenzhen 518122, China
    2. School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
    3. Department of Science and Education, PingShan General Hospital of Southern Medical University, Shenzhen 518118, China
  • Received:2023-08-31 Revised:2024-03-24 Published:2024-07-05 Online:2024-04-28
  • Contact: WANG Haoxiang

摘要: 背景 美国临床内分泌学家协会和美国内分泌学会提出基于脂肪组织过多引起的慢性疾病(ABCD)模型来评价肥胖,目前国内针对ABCD的研究极少,应用效能也尚不清楚。 目的 运用ABCD这一新的肥胖评价指标,了解中国65岁及以上老年人群中ABCD的患病情况及其影响因素。 方法 选择2021年1—12月参加广东省深圳市坪山区28家社区健康服务中心体检的65岁及以上老年人5 562名,通过问卷调查、体格检查、实验室检测获取研究对象基本特征,根据ABCD模型的诊断标准对样本人群进行ABCD分期,计算ABCD及各个分期的患病率,采用多因素Logistic回归分析探究ABCD分期与不同心脏代谢危险因素风险的关系。 结果 本研究中ABCD患病率为71.0%,0期、1期、2期患病率分别为4.8%(267/5 562)、32.5%(1 808/5 562)、33.7%(1 874/5 562)。多因素Logistic回归分析结果显示,以ABCD正常为参照组,除高总胆固醇与饮酒外,糖尿病、高血压、三酰甘油升高、高密度脂蛋白胆固醇降低、低密度脂蛋白胆固醇升高、吸烟与ABCD分期存在关联(P<0.05);ABCD 1期发生高血压、三酰甘油升高、高密度脂蛋白胆固醇降低、低密度脂蛋白胆固醇升高的风险分别是正常人群的2.393倍、1.515倍、1.940倍、1.688倍、1.376倍;ABCD 2期发生糖尿病、高血压、三酰甘油升高、高密度脂蛋白胆固醇降低、低密度脂蛋白胆固醇升高的风险分别是正常人群的2.918倍、4.231倍、9.282倍、4.128倍、2.970倍、1.672倍。吸烟是ABCD 1期和2期的保护因素,OR(95%CI)分别为0.577(0.480~0.693)、0.752(0.633~0.893)。 结论 本研究中65岁及以上老年人ABCD患病情况存在男女差异,患病率与高血压、糖尿病、吸烟等心脏代谢危险因素存在关联,ABCD模型在中国老年人群中应用效果良好。

关键词: 肥胖症, 脂肪组织过多引起的慢性疾病, 脂肪组织, 慢性疾病, 老年人, 流行病学研究, 影响因素分析

Abstract:

Background

The American Association of Clinical Endocrinologists and the American Society of Endocrinology have proposed an adiposity-based chronic disease (ABCD) model for evaluating obesity, and there has been very few studies of ABCD in China, and the efficacy of its application is unclear.

Objective

To understand the prevalence of ABCD and its root cause in the Chinese elderly population aged 65 years and above using ABCD, a new obesity evaluation index.

Methods

Five thousand five hundred and sixty-two elderly people aged 65 years and above who participated in medical checkups at 28 community health centers in Pingshan District, Shenzhen City, Guangdong Province, from January to December 2021 were selected to obtain the basic characteristics of the study subjects through questionnaires, physical examinations, and laboratory tests, and to stage the sample population according to the diagnostic criteria of the ABCD model, and calculate the prevalence rates of ABCD and the individual stage, and multifactorial Logistic regression analysis was used to explore the relationship between ABCD staging and different cardiometabolic risk factor risks.

Results

The prevalence of ABCD in this study was 71.0%, and the prevalence of stage 0, 1, and 2 were 4.8% (267/5 562) , 32.5% (1 808/5 562) , and 33.7% (1 874/5 562) , respectively. The results of multifactorial Logistic regression analysis showed that, using ABCD normal as the reference group, diabetes mellitus, hypertension, high triacylglycerol, low HDL-C, high LDL-C, and cigarette smoking, in addition to high total cholesterol and alcohol consumption, were associated with the stage of ABCD (P<0.05) ; The risk of developing hypertension, high triacylglycerol, low HDL-C, and high LDL-C in ABCD stage 1 was 2.393, 1.515, 1.940, 1.688, and 1.376 times higher than that of the normal population, respectively; The risk of diabetes, hypertension, high triacylglycerol, low HDL-C, and high LDL-C in ABCD stage 2 was 2.918, 4.231, 9.282, 4.128, 2.970, and 1.672 times higher than that of the normal population, respectively. Smoking was a protective factor for ABCD stage 1 and 2, with OR (95%CI) of 0.577 (0.480-0.693) and 0.752 (0.633-0.893) , respectively.

Conclusion

In this study, there were male-female differences in the prevalence of ABCD in the elderly aged 65 years and older, and the prevalence was associated with cardiometabolic risk factors such as hypertension, diabetes, and smoking, and the ABCD model has been well applied in the Chinese elderly population.

Key words: Obesity, ABCD, Adipose tissue, Chronic disease, Senior citizen, Epidemiologic studies, Root cause analysis