关键词: 乳腺肿瘤；癌, 小叶状；肿瘤浸润；诊断；治疗；预后；综述

Abstract: Breast cancer is the highest prevalent malignant tumor worldwide，with a variety of histological types，among which invasive lobular carcinoma（ILC）of breast is the second most common histologic type，accounting for about 5%-15% of invasive tumors，showing an increased prevalence in the past 30 years. The major characteristic of ILC of breast is the loss of E-cadherin，which leads to the absence of adhesion between cells. The special diffuse infiltration and growth of ILC of breast pose some challenges to clinical physical and imaging examinations. Even if most patients with ILC of breast are hormone-receptor positive and sensitive to endocrine therapy，the problem of treatment resistance is inevitable in clinical applications. In addition，recent studies have found that the prognosis of ILC of breast is not as good as previously reported，and the principle of treatment based only on tumor stage and molecular typing does not seem to be fully applicable. It is possibly necessary to study ILC of breast as an independent clinical entity. In this paper，we reviewed the epidemiological and clinical characteristics，pathological and molecular characteristics，diagnosis，treatment，prognosis，and future treatment of ILC of breast，so as to better clinicians' understanding of clinical diagnosis and individualized treatment of ILC of breast.

Key words: Breast neoplasms；Carcinoma, lobular；Neoplasm invasiveness；Diagnosis；Therapy；Prognosis；Review