关键词: 新型冠状病毒肺炎, 新型冠状病毒, 临床特征, 武汉

Abstract: Background　The previous data on COVID-19 clinical features in Wuhan were mostly collected from a single hospital，with limited representation. There are lack of large-sample studies on COVID-19 deaths in the entire Wuhan area.Objective　To analyze the clinical characteristics of 2 231 COVID-19 deaths in Wuhan，so as to provide information for developing diagnostic and therapeutic projects and research of COVID-19.Methods　During January 9 to March 8，2020，we collected the essential information and summary of medical records of 2 231 COVID-19 deaths via reviewing the printed reports submitted by workers from medical affairs department from 66 hospitals in Wuhanwor15 districts〔Jiangadi District，Jianghan District，Qiaokou District，Hanyang District，Wuchang District，Qingshan District，Hongshan District，Caidian District，Jiangxia District，Dongxihu District，Wuhan Economic & Technological Development Zone （Hannan），Huangpi District，Xinzhou District，East Lake High-tech Development Zone and East Lake Scenic Area〕.The information we counted includes：symptom onset time，first visit time，admission time，diagnosis time，death time，past history，clinical symptoms and treatment measures.Results　Death cases mostly occurred in February.The average interval between the first symptom onset and the first medical visit was（4.3±5.5）days，between the first symptom onset and hospitalization was（9.2±7.5）days，and between the first medical visit and confirmed diagnosis was（6.9±7.6）days.Of the 2 231 deaths，1 465（65.67%） were men and 766（34.33%）were women.They died at an average age of （70.2±11.9）years，specifically，the youngest was 14 years，and the oldest was 100 years，1 863（83.51%） died at the age of over 60，and 36（1.61%）died at the age of less than 40.Underlying diseases were prevalent in 1 708 cases（76.56%），among which the top seven were hypertension，diabetes，heart disease，respiratory disease，cerebrovascular disease，chronic kidney disease，and malignant tumor.1 173（52.58%）were mechanically ventilated，547 of them had invasive mechanical ventilation，and 33 had ECMO.302（13.54%） received renal replacement therapy.283（12.68%）abandoned rescue.Conclusion　The shortage of medical resources caused low treatment efficiency in the early stage of the pandemic.With the improvement of the treatment capacity，the number of deaths gradually decreased.Male COVID-19 patients，over 60 years old，and with underlying diseases were related to higher risk of death.

Key words: COVID-19, SARS-CoV-2, Clinical characteristics, Wuhan