Respiratory problems in chronic obstructive pulmonary disease (COPD) patients are prone to poor sleep quality, anxiety and depression, but they are often ignored by medical staff and patients themselves. Understanding the sleep quality, anxiety and depression symptoms of patients with COPD and their influencing factors can help to improve the quality of life of patients, however, there are few relevant studies.

To investigate the sleep quality, anxiety and depression of patients with COPD and explore the influencing factors.

Convenience sampling was used to recruit COPD patients who visited the Department Respiratory Diseases and Critical Care Medicine of seven hospitals in Anhui Province from August to November 2022. Demographic characteristics, dyspnea grade, airflow restriction severity, risk of malnutrition, physical activity level, vaccination, and acute exacerbations in the last 1 year were collected. The Pittsburgh Sleep Quality Index (PSQI) and the Hospital Anxiety and Depression Scale (HADS) were used to evaluate the sleep quality and anxiety and depression symptoms of COPD patients, and the influencing factors were analyzed by multivariate Logistic regression.

A total of 248 patients with COPD were investigated, among which the incidence of poor sleep quality was 60.9% (151/248), only 8.9% (22/248) of the patients thought they had good sleep quality, and more than half of the patients actually had insufficient sleep time (54.4%) or low sleep efficiency (60.1%). 29.4% (73/248) of COPD patients had at least one of the symptoms of anxiety or depression, of which 35 had anxiety symptoms, 61 had depression symptoms, and 23 had both anxiety and depression symptoms. Multivariate Logistic regression analysis showed that older ages (OR=1.052, 95%CI=1.018-1.086) and risk of malnutrition (OR=3.393, 95%CI=1.855-6.206) were risk factors for poor sleep quality in COPD patients. Regular physical activity was a protective factor for poor sleep quality in COPD patients (OR=0.450, 95%CI=0.242-0.834) (P<0.05). Acute exacerbations ≥2 times (OR=2.220, 95%CI=1.093-4.510) and malnutrition risk (OR=1.961, 95%CI=1.044-3.683) were risk factors for anxiety and depression symptoms in COPD patients (P<0.04). In COPD patients, PSQI score was positively correlated with HADS-A (r_s=0.413) and HADS-D score (r_s=0.430), and there was a positive correlation between HADS-A score and HADS-D score (r_s=0.719, P<0.05) .

The incidence of poor sleep quality, anxiety and depression symptoms was high in COPD patients, and age, malnutrition risk, regular physical activity and number of acute exacerbations in the past year are important influencing factors. Medical staff, family members and patients themselves should improve the awareness of sleep quality, anxiety and depression, and actively carry out screening and intervention work for key patients to improve the sleep quality and mental health of patients.

In the current rehabilitation environment, emotional issues and cognitive dysfunctions in stroke patients are often overshadowed by physical, speech, and swallowing difficulties, leading to their underestimation in clinical rehabilitation. This oversight can result in adverse outcomes, impacting the overall success of rehabilitation. Currently, clinical treatments primarily rely on pharmacotherapy to alleviate symptoms, which has limited effectiveness and can cause a range of adverse reactions.

To observe the efficacy of precision exercise prescriptions on anxiety, depression, and cognitive functions in stroke patients and to preliminarily analyze the underlying mechanisms of action.

A total of 84 stroke patients hospitalized in the Rehabilitation Department of Changzhou Dean Hospital from January 2022 to March 2023 were selected. They were randomly divided into a control group (42 patients) and an experimental group (42 patients). The control group received standard rehabilitation treatment, while the experimental group received precision exercise prescriptions based on cardiopulmonary exercise testing (CPET) results in addition to standard rehabilitation, over 12 weeks. The Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Mini-mental State Examination (MMSE) scores, and Homocysteine (Hcy) levels were compared before and after rehabilitation training in both groups. A Pearson correlation analysis was conducted between pre-rehabilitation Hcy levels and SAS, SDS, MMSE scores.

All 42 patients in the experimental group completed the CPET and the 12-week precision exercise prescription rehabilitation without any adverse events. Before rehabilitation training, there were no statistically significant differences in SAS, SDS, MMSE scores, and Hcy levels between the two groups (P>0.05). After rehabilitation training, the scores of SAS, SDS, and Hcy levels in the experimental group were significantly lower compared to pre-treatment values (P<0.05), and which were significantly lower than those of the control group (P<0.05). The MMSE score in experimental groups increased significantly after interventions compared to pre-treatment value (P<0.05), and it was significantly higher than that of the control group (P<0.05). There were no significant differences in SAS, SDS, MMSE scores, and Hcy levels before and after rehabilitation training in the control group (P>0.05). Pearson correlation analysis revealed a positive correlation between Hcy levels and SAS, SDS scores (r-values of 0.420 and 0.507, respectively, P<0.05) and no correlation with MMSE scores (r=0.079, P=0.473) .

Our findings suggest that precision exercise prescriptions significantly improve anxiety, depression, and cognitive functions in stroke patients, suggesting their potential as a novel therapeutic approach in clinical applications. Hcy may be one of the mechanisms through which precision exercise prescriptions improve anxiety and depression in stroke patients. Further research is needed to determine whether Hcy is related to the improvement of cognitive functions through this prescription.

As a common affective mental disorder, depressive disorder has currently become the second health burden worldwide, however, its pathogenesis remains to be further elucidated. The clinical treatment of depressive disorder primarily relies on western medicine. However, there is great clinical need for effective and rapid-onset antidepressants for the unsatisfactory effect, obvious treatment time-lag, and intolerable adverse reactions of current drug treatment. Ferroptosis is a novel form of cell death discovered in recent years, which has been found to be involved in the pathogenesis of numerous neurological disorders, including depressive disorder. Currently, some studies have shifted the focus of antidepressant treatment towards targeted inhibition of ferroptosis, and achieved positive outcomes. The present paper provides a comprehensive review of the involvement of ferroptosis in depressive disorder pathogenesis and its potential therapeutic implications, drawing on clinical and preclinical evidence that elucidates the underlying mechanisms linking depressive disorder with ferroptotic processes.

China has been already in the stage of deeply aging society, and the health problems of the elderly are getting more and more attention. Depression in the elderly not only affects the quality of life in later life, but also increases the economic burden on society and families, so early identification of the influencing factors of its development is of great significance. However, the existing research conclusions are still controversial, and there are few relevant systematic reviews in China.

To explore the depression detection rate and its influencing factors in the elderly in China since 2018, provide reference for reducing the incidence of depression in the elderly and promoting healthy aging.

In January 2023, PubMed, EmBase, Web of Science, CNKI, Wanfang Date and VIP were searched for publicly available studies on factors influencing depression in Chinese elderly from 2018 to 2022. The data were extracted and the literature quality was evaluated according to the cross-sectional study quality assessment criteria of Agency for Healthcare Research and Quality (AHRQ) and Stata 15.0 was adopted for Meta-analysis.

Twenty-three papers were finally included, with a cumulative study population of 75 599, and a total of 13 815 depressed older adults were detected; the AHRQ quality assessment scores of the papers ranged from 5 to 7. Meta-analysis results showed that the detection rate of depression in the elderly in China was 20.6%〔95%CI (16.6%, 24.8%) 〕, female〔OR=1.46, 95%CI (1.30, 1.64) 〕, advanced age〔OR=1.48, 95%CI (1.13, 1.94) 〕, lower education level〔OR=1.52, 95%CI (1.32, 1.75) 〕, no spouse〔OR=1.60, 95%CI (1.35, 1.91) 〕, living in rural areas〔OR=1.38, 95%CI (1.14, 1.66) 〕, suffering from chronic diseases〔OR=2.75, 95%CI (2.07, 3.66) 〕, 2 chronic diseases〔OR=1.84, 95%CI (1.07, 3.14) 〕, 3 or more chronic diseases〔OR=3.86, 95%CI (2.89, 5.15) 〕, poor self-rated health〔OR=3.47, 95%CI (1.14, 10.53) 〕, insomnia〔OR=2.62, 95%CI (1.88, 3.66) 〕, living alone〔OR=1.86, 95%CI (1.56, 2.21) 〕, no exercise〔OR=1.88, 95%CI (1.60, 2.20) 〕, self-care needs or partial needs〔OR=2.96, 95%CI (1.12, 7.85) 〕were risk factors for depression in the elderly (P<0.05), while drinking〔OR=0.67, 95%CI (0.50, 0.88) 〕and having friends〔OR=0.52, 95%CI (0.38, 0.71) 〕were protective factors (P<0.05) .

Although the detection rate of depression among elderly in China has decreased, it is still at a high level, and the elderly in China who are female, elderly, less educated, without spouse, living in rural areas, suffering from chronic diseases and chronic disease comorbidity, with poor self-rated health, suffering from insomnia, living alone, without exercise, and living in need or partial need of self-care may be more likely to suffer from depression.

Whether considering the cumulative effect of sustained C-reactive protein (CRP) and distinguishing different aspects of depressive symptoms may be the reasons for the inconsistent conclusions of previous studies on the association between CRP and depressive symptoms among middle-aged and older adults. The relationship between cumulative effects of CRP elevations and different aspects of depressive symptoms in middle-aged and older adults in China is not well understood.

This study aims to examine the relationship between cumulative episodes of CRP elevations over two successive determinations and depressive symptoms, as well as somatic and non-somatic retardation, among Chinese middle-aged and older adults.

This study used public data from the 2011-2018 Chinese Health and Retirement Longitudinal Study (CHARLS) and included 3 868 subjects. They were categorized based on the frequency of CRP elevations over two consecutive measurements: "elevated on zero occasion" (n=2 918), "elevated on one occasion" (n=763), and "elevated on two occasions" (n=187). Depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale (CESD-10) in 2011, 2015, and 2018, capturing both somatic and non-somatic dimensions. Multiple linear was used to explore the associations between cumulative episodes of CRP elevations over two successive determinations with depressive symptom scores in 2018, as well as the scores of somatic and non-somatic components separately. Multivariate Logistic regression was used to investigate the effects of cumulative episodes of CRP elevations on the risk of depressive symptoms in 2018.

The results of multiple linear regression analysis showed that after adjusting for all covariates, elevated on two occasions compared with elevated on zero occasion, which was an influential factor for the total score of depressive symptoms (β=1.22, P<0.05), the score of somatic depressive symptoms (β=0.51, P<0.05) and the score of non-somatic symptoms (β=0.71, P<0.05). Logistic regression analysis showed that after adjusting for all covariates, elevated on two occasions were associated with a higher risk of depressive symptoms than elevated on zero occasion (OR=1.64, 95%CI=1.18-2.29) .

Among Chinese middle-aged and older adults, there is a positive association between cumulative effects of CRP elevations and depressive symptoms, encompassing both somatic and non-somatic retardation. Addressing chronic inflammation and treating chronic inflammatory diseases promptly may help mitigate depression risk.

Social environment and psychological factors have a notable impact on professional identity. Currently, there are no available studies on relationships between perception of workplace violence (WPV) by patients, psychological capital (PsyCap) , and professional identity among general practitioners (GPs) in China.

To investigate the relationships between perceived WPV by patients, PsyCap, and professional identity among GPs in China.

A self-administered electronic questionnaire survey was conducted with 4 632 GPs selected by use of stratified multistage random sampling from eastern, central, and western China between March and May 2021. The survey was used for collecting data mainly consisting of GPs' basic demographics, perceived WPV by patients, PsyCap, and professional identity. Spearman's correlation was used to analyze relationships between perceived WPV by patients, PsyCap, and professional identity. Hierarchical multiple regression analysis was used to analyze the effects of perceived WPV by patients and PsyCap on professional identity.

Altogether, 94.47% of the GPs (4 376/4 632) who handed in responsive questionnaires were included for analysis. Six hundred and twenty-four (14.26%) GPs had experienced WPV by patients in the past year. The average total scores of PsyCap and professional identity were (102.89±16.94) and (33.93±8.95) , respectively. The increase in the score of perceived WPV by patients was correlated with a decrease in the scores of PsyCap and its dimensions, and in the score of professional identity (P<0.01) . The increase in the scores of PsyCap and its dimensions was correlated with increased score of professional identity (P<0.01) . Hierarchical multiple regression analysis showed that the frequency of WPV by patients had a negative predictive effect on professional identity (low frequency, b=-0.071; intermediate frequency, b=-0.054; high frequency, b=-0.042; P<0.001) . PsyCap had a positively predicted effect on professional identity (b=0.330, P<0.001) , and it played a partial mediating role between perceived WPV by patients and professional identity.

The GPs' perceived WPV by patients, PsyCap, and professional identity are interrelated, and PsyCap plays a partial mediating role between perceived WPV by patients and professional identity. Great importance should be attached to the professional work environment, occupational status, and mental health among Chinese GPs.

Worldwide, breast cancer has become the most common malignancy, and many breast cancer survivors struggle with psychological problems in treatment and recovery. The efficacy of mindfulness-based stress reduction (MBSR) in the psychological care of breast cancer patients has been confirmed in many systematic reviews (SRs) . However, due to inconsistent outcome measures used in various SRs, the review results cannot be directly applied to clinical practice.

To perform an overview of the SRs of the efficacy of MBSR in breast cancer patients, providing a reference for the making of psychological care interventions for these patients.

PubMed, Embase, Cochrane Library, Web of Science, CINAHL, PsycINFO, JBI, CNKI, Wanfang Data, and CBM were searched from inception to July 2022 for SRs of patients with breast cancer treated with MBSR. Literature screening and data extraction were performed by two researchers independently. Methodological quality was assessed using the AMSTAR 2. The standardization of reporting quality was assessed using the PRISMA checklist. Quality of evidence and strength of recommendations were assessed using the GRADE approach. The confidence of evidence from qualitative SRs was assessed using the CERQual.

Fourteen SRs were included. The methodological quality of included SRs was generally low, with only one being of high quality and two fatally missing key items. The defects in reporting quality were mainly in study protocol registration, risk of bias assessment and funding sources. Fifteen outcomes and 73 evidence bodies (0, 31, 28 and 6 were classified as high, moderate, low, and very low quality, respectively, by the GRADE approach, and the other 8 were classified as low quality by the CERQual approach) were identified in the SRs in total. MBSR could relieve anxiety, depression, fatigue, and stress in breast cancer patients to varying degrees, whose efficacy has proven to be significant in a short-term, but is uncertain in a long-term.

Generally, SRs on MBSR improving psychological condition in breast cancer patients contain unsatisfactory quality of evidence, whose methodological quality and standardization level of reporting quality still need to be improved further. Moreover, the shorter-term effect of MBSR has been confirmed, but its long-term effect is uncertain, and requires to be evaluated by more high-quality, large-sample clinical studies.

Depression is a common psychiatric disorder with limited treatment options. Deep transcranial magnetic stimulation (dTMS), as a new non-invasive neuromodulation technique, has been utilized in the treatment of major depressive disorder (MDD), but there is less evidence from clinical studies.

To explore the clinical efficacy of dTMS combined with escitalopram oxalate (Esc) in the treatment of depression, and provide further reliable data reference for dTMS in the treatment of depression patients.

A total of 73 patients with depression who attended Department of Psychiatry, Affiliated Hospital of Guizhou Medical University from December 2021 to January 2023 were selected as the study subjects and divided into the control group (n=35) and combined treatment group (n=38) according to the random number table. Patients in the control group were given Esc ( 10 mg per day in the first week and 20 mg per day from the second week for 2 consecutive weeks). The combined treatment group received the treatment of dTMS (left DLPFC as the stimulation target, 18 Hz, 120%MT, 1 980 times per day for 2 weeks, 10 times in total) based on the same treatment for the control group. The depressive symptoms and cognitive improvement of patients in the two groups were evaluated before and after the two weeks of treatments by Hamilton depression scale (HAMD), Beck Scale for Suicide Ideation (BSS), Montreal Cognitive Assessment Scale (MoCA) and the mean oxygenated hemoglobin (oxy-Hb) concentration in the prefrontal cortex measured by functional near-infrared spectroscopy (fNIRS) based on the verbal fluency text (VFT) task.

The actual completion of the trial was 30 cases in the control group and 31 cases in the combined treatment group. After treatment, the HAMD and BSS scores of the combined treatment group were lower than those of the control group, and the MoCA score was higher than that of the control group (P<0.05). After treatment, the HAMD and BSS scores of patients in the two groups were lower than those before treatment, and the MoCA score was higher than that before treatment (P<0.05). There was no significant activation of the prefrontal cortex after treatment in both groups. The improvement of depression symptoms and cognitive function in the combined treatment group was better than that in the control group.

The combination of dTMS and Esc can improve the depressive symptoms and cognitive function better than Esc treatment alone in depression patients.

The prevalence of synthetic drug abuse is high. In China, synthetic drugs have become the most commonly abused drugs characterized by strong addiction and great difficulty in quitting. The addicts are easily prone to serious psychological dependence and other psychological problems, which leading to relapse after withdrawal treatment. Therefore, exploring the influencing factors of mental health status in individuals addicted to new synthetic drugs has clinical and social significance for the prevention and management of synthetic drug addicts.

To explore the associated factors of mental health status and their intercorrelations in individuals addicted to new synthetic drugs.

One hundred and ninety-six people getting addicted to new synthetic drugs with inpatient withdrawal treatment were selected from Ankang Hospital of Tianjin Municipal Public Security Bureau from January 2018 to April 2019. Sociodemographic data and drug abuse-related clinical data were collected. The Symptom Checklist-90 (SCL-90) , Eysenck Personality Questionaire-Revised, Short Scale For Chinese (EPQ-RSC) , and Simplified Coping Style Questionnaire (SCSQ) were used to investigate the mental health. Spearman rank correlation analysis was used to analyze the inercorrelations of the influencing factors of mental health. SPSS 22.0 software was used for statistical analysis, and AMOS 22.0 was used to build a model for path analysis of data.

The average total score of SCL-90 rated by the participants was (206.62±26.66) , which was higher than that rated by Chinese norm (P<0.001) . Moreover, the average score of each domain rated by the participants was also higher that rated by Chinese norm (P<0.001) . Spearman rank correlation analysis showed that the total score of SCL-90 was negatively correlated with age (r_s=-0.285, P<0.001) , and positive coping (r_s=-0.749, P<0.001) , but was positively correlated with economic income (r_s=0.210, P=0.003) , daily dose of a new synthetic drug (r_s=0.375, P<0.001) , negative coping (r_s=0.754, P<0.001) , and dimensions of personality traits 〔psychoticism (r_s=0.915) 、introversion and extroversion (r_s=0.748) 、neuroticism (r_s=0.549) 、lying (r_s=0.979) , P<0.001) 〕. Path analysis revealed that personality traits and coping styles could directly or indirectly affect the mental health status, and coping styles played a partial mediating role in the relationship of personality traits with mental health status.

The prevalence of normal mental health was low in people addicted to new synthetic drugs, which was mainly associated with personality traits and coping styles. In view of this, it is suggested to improve the mental health of these addicts by taking actions to develop positive coping styles and reduce negative coping styles according to their personality traits.

Drug therapy is one of the main treatment approaches for depression, and a consideration of patient preferences can effectively improve patient compliance with medication. Several studies have been conducted to explore the medication choice preferences of patients with depression, but there is a lack of studies to systematically collect and summarize the medication choice preferences of patients with depression.

To systematically review the studies related to the application of discrete choice experiment (DCE) and best-worst scaling (BWS) to the medication choice preferences of patients with depression, in order to provide reference for clinical rational drug use of patients with depression and future studies of preferences.

CNKI, Wanfang Data Knowledge Service Platform, VIP, PubMed, Web of Science and EmBase were systematically searched for the studies related to the application of DCE and BWS to the medication choice preferences of patients with depression from inception to 2021-12-31, using "DCE" "BWS" "depression" "discrete choice experiment" "best-worst scaling" as keywords on January 2022. Data were extracted from the included literature, and the PREFS checklist was used for the quality assessment of all studies. The attributes included in the study were classified into three categories of outcome, process and cost, and their relative importance on the impact of medication preferences of patients was assessed.

A total of 7 papers were included, all of which were studies related to DCE, involving 47 attributes, among which 41 were classified as outcome attributes, 5 were classified as process attributes, and 1 was classified as a cost attribute. A total of 9 most important attribute results were obtained from the 7 studies, the outcome attribute was considered most important 8 times and the cost attribute was considered most important 1 time. Among the outcome attributes, adverse effects were considered most important 5 times and effectiveness was considered most important 3 times. Based on the PREFS checklist, one study received a score of four and six studies received a score of three. Most studies need further improvement in terms of respondents and findings.

Outcome attributes are most important in the medicine taking process of patients with depression, which needs attention of clinicians and policy makers. There is room for improvement in the dimensions of variance reporting and experimental design, it is recommended for further improvement of research design in terms of respondents interpretation of findings and experimental design in future research, in order to provide more high-quality evidence for research of medication preferences of patients with depression.

There are a large number of middle-aged and elderly patients with chronic diseases. However, there is currently limited research on the depression status and influencing factors of middle-aged and elderly patients with chronic diseases nationwide.

By exploring the depression status and influencing factors of middle-aged and elderly patients with chronic diseases in China, to provide a reference for improving their mental health status.

According to the fifth round of national survey data conducted by the China Health and Retirement Longitudinal Study (CHARLS) in 2020, a total of 12 551 middle-aged and elderly patients with chronic diseases were selected as the study objects. The depression status of the study objects was measured using the Center for Epidemiologic Studies Depression Scale (CES-D), and the main factors affecting the depression status of middle-aged and elderly patients with chronic diseases were analyzed using the chi-square test and multivariate Logistic regression.

Among middle-aged and elderly patients with chronic diseases, the proportion of those with depressive symptoms was 40.7% (5 111/12 551). The results of multivariate Logistic regression analysis showed that: gender (male: OR=0.613, 95%CI=0.553-0.680), age (65-<75 years old: OR=0.862, 95%CI=0.769-0.965; ≥75 years old: OR=0.604, 95%CI=0.510-0.716), presence of spouse/partner living together or not (have OR=0.730, 95%CI=0.648-0.822), places of residence (rural: OR=1.515, 95%CI=1.387-1.654), educational levels (junior high school: OR=0.727, 95%CI=0.657-0.805; senior high school and above: OR=0.561, 95%CI=0.488-0.646), social status (1 item: OR=0.870, 95%CI=0.793-0.956; ≥ 2 items: OR=0.866, 95%CI=0.779-0.963), satisfaction with child relationships (satisfaction: OR=0.266, 95%CI=0.218-0.324), smoking (OR=1.131, 95%CI=1.014-1.263), alcohol consumption (OR=0.873, 95%CI=0.795-0.959), nighttime sleep duration (6-<8 h: OR=0.539, 95%CI=0.493-0.590; ≥8 h: OR=0.443, 95%CI=0.396-0.495), BADL (damaged: OR=1.875, 95%CI=1.692-2.077), IADL (damaged: OR=2.251, 95%CI=2.030-2.496), number of chronic diseases (2 types: OR=1.202, 95%CI=1.076-1.342; 3 types: OR=1.452, 95%CI=1.289-1.636; ≥ 4 types: OR=1.954, 95%CI=1.749-2.183) were the influencing factors of depression symptoms in middle-aged and elderly patients with chronic diseases (P<0.05) .

The incidence of depressive symptoms in middle-aged and elderly patients with chronic diseases is 40.7%, and the situation is not optimistic. Their depression is influenced by various factors. Healthcare institutions and policymakers should pay attention to their mental health and take targeted measures from personal, family, community, and other aspects to improve.

In China, 80% of the grandparents are taking part in caring for grandchildren. However, it has been found by available studies that involvement in taking care of grandchildren may increase the risk of depression among grandparents, which would seriously harm their quality of life, and the risk of depression is associated with parent-grandparent coparenting conflict, grandparents' sense of valued elder and sense of mastery, but the underlying mechanism still requires further investigation.

To investigate the influence of parent-grandparent coparenting conflict on grandparents' depression, and to explore the mediating and moderating mechanisms that grandparents' sense of mastery and sense of valued elder may play in it.

This study used two surveys. Grandparents (totally 626 cases) who participated in caring for grandchildren were selected by snowball sampling to attend an online survey or by convenience sampling to attend an offline survey from August to November 2021 using four questionnaires, namely the Coparenting Relationship Scale (CRS), the Pearlin Mastery scale (PMS), Grandparent Meaning Scale (GMS), and the 9-item Chinese version of the Center for Epidemiological Studies Depression Scale (CES-D-C). Pearson correlation was used to analyze the relationship of mother-grandparent coparenting conflict score, father-grandparent coparenting conflict score, PMS score, score of the valued elder dimension of the GMS and CES-D-C. PROCESS was used to examine the mediating effect of grandparents' sense of mastery and the moderating effect of their sense of valued elder between parent-grandparent coparenting conflict and grandparents' depression, and to draw a simple slope diagram.

A total of 626 cases returned responsive questionnaires, with a response rate of 99.2%. The prevalence of depression tendency was 12.0% (75/626) in this study. The score of CES-D-C〔 (5.36±4.14) 〕 was found to be significantly positively correlated with mother-grandparent coparenting conflict score〔 (9.87±3.08), r=0.28, P<0.05〕, and father-grandparent coparenting conflict score〔 (7.34±3.25), r=0.35, P<0.05〕, but was negatively correlated with the PMS score 〔 (12.61±5.48), r=-0.25, P<0.05〕and the score of valued elder dimension〔 (84.13±8.58), r=-0.21, P<0.05〕. Grandparents' sense of mastery partially mediated the relationship of grandparents' depression with mother-grandparent coparenting conflict (with a size of indirect effect of 0.05, accounting for 17.2% of the total effects) and father-grandparent coparenting conflict (with a size of indirect effect of 0.04, accounting for 11.4% of the total effects). Grandparents' sense of valued elder moderated the relationship of grandparents' depression with mother-grandparent coparenting conflict (b=-0.06, P<0.05), and father-grandparent coparenting conflict (b=-0.07, P<0.05). The results of simple slope tests showed that among those with lower sense of valued elder, father-grandparent or mother-grandparent co-parenting conflict had a stronger influence on their depression than their counterparts with higher sense of valued elder.

Parent-grandparent (either mother-grandparent or father-grandparent) coparenting conflict is an important associated factor for grandparent's depression In this association, grandparent's sense of mastery plays a mediating role, while grandparent's sense of valued elder exerts a moderating effect. To reduce the risk of depression and promote the metal health among elders who take part in coparenting, efforts can be made to reduce coparenting conflicts and enhance the elders' sense of mastery and sense of valued elder.

In China, as population aging quickens, multimorbidity has become a major public health problem threatening the health of elderly people. Multimorbidity has a negative impact on mental health, but there is a lack of research on its association with anxiety symptoms in elderly people.

To investigate the influence of multimorbidity on anxiety symptoms among Chinese elderly people, so as to provide references for improving mental health for older people with multimorbidity.

We selected 6 854 older adults (≥65 years old) from the participants of the Chinese Longitudinal Healthy Longevity Survey 2018 from December 2022 to February 2023. The 7-item Generalized Anxiety Disorder Scale was used to assess symptoms of anxiety. Multimorbidity was defined as having two or more coexisting chronic conditions, while non-multimorbidity was defined as having only one or no chronic condition. Propensity score matching (PSM) was used tomatch individuals with and without multimorbidity. The association of multimorbidity with anxiety symptoms was analyzed by univariate and multivariate Logistic regression analyses.

Among the 6 854 cases, the prevalence of multimorbidity and anxiety symptoms was 38.04% (2 607/6 854), and 10.53% (722/6 854), respectively. There were 4 247 cases (61.96%) without multimorbidity, of whom 2 102 (30.67%) had no chronic disease, and 2 145 (31.29%) had one chronic disease. A total of 2 282 pairs of multimorbidity and non-multimorbidity (4 564 cases altogether) were obtained after matching. Multivariate Logistic regression analysis showed that multimorbidity was the risk factor of anxiety symptoms〔OR=1.399, 95%CI (1.166, 1.679), P<0.001〕. Besides that, gender, ability to perform activities of daily living and receiving a pension were also related to anxiety symptoms (P<0.05). Five hundred and twenty-two pairs (1 044 cases altogether) were obtained after matching the subjects with multimorbidity and those with one chronic disease using PSM, and the analysis found that those with one chronic disease had higher prevalence of anxiety symptoms〔64.76% (215/332) vs 43.12% (307/712) 〕 (P<0.001) .

Compared with their counterparts without multimorbidity, elderly people with multimorbidity had higher risk of anxiety symptoms, so more attentions should be paid to the mental health of these people.

Bariatric surgery is the effective treatment for obesity, however, the effect of surgery on patients' psychological status is still unclear.

To investigate the treatment effects of bariatric surgery on patients' psychological status one year after the surgery.

This is a retrospective cross-sectional study. This study selected 172 patients who underwent bariatric surgery in the department of general surgery, First Affiliated Hospital of Nanjing Medical University during June 2019 to June 2020, and collected their clinical data. The indicators of the treatment effects of bariatric surgery include body composition indicators〔Weight, Body mass index (BMI) , Percentage of excess weight loss (EWL%) , Body muscle mass (BM) , Body fat mass (BF) , Visceral fat (VSF) , metabolism-related biochemical indexes〔Alanine aminotransferase (ALT) , Aspartate aminotransferase (AST) , Total protein (TP) , Albumin (ALB) 〕, preoperative comorbidities, relief of comorbidities after surgery, postoperative complications, postoperative complaints, surgery methods; Indicators of the postoperative psychological status include quality of life, perceived stress, general well-being and satisfaction degree of surgery. This study used the12-item Short Form Survey (SF-12) , Chinese version of the Perceived Stress Scale (CPSS) , General Well-being Schedule (GWS) , Questionnaire of Bariatric Surgery Patient' Satisfaction Survey to investigate the psychological status. This study used the Pearson correlation analysis and Spearman rank correlation analysis to explore the correlation between body composition indicators and metabolic-related biochemical indexes and postoperative psychological status, used the multivariate linear regression analysis to explore the factors that affect postoperative psychological status.

One year after surgery, EWL% was (82.7±31.7) %, and BMI decreased by (10.3±4.3) kg/m². 96 patients (55.8%) had metabolic-related comorbidities such as type 2 diabetes mellitus, hypertension, fatty liver before surgery, 48 patients (27.9%) achieved complete remission, 30 patients (17.4%) achieved partial remission, and 18 patients (10.5%) had no remission after surgery. Patients'weight, BMI, BM, BF, VSF, ALT, AST were lower than those before surgery, the TP and ALB were higher than those before surgery (P<0.05) .The correlation analysis showed that patients' MCS scores were negatively correlated with ΔALT (r_s=-0.160, P=0.036) ; the CPSS scores were negatively correlated with EWL% (r=-0.181, P=0.017) and ΔBM% (r_s=-0.174, P=0.022) but positively correlated with ΔALT (r_s=-0.236, P=0.002) ; the GWS scores were negatively correlated with ΔALT (r_s=-0.228, P=0.003) and ΔAST (r_s=-0.216, P=0.004) ; the satisfaction of surgery were negatively correlated with ΔBMI (r=-0.171, P=0.025) , ΔBF% (r=-0.174, P=0.022) and ΔVSF (r=-0.154, P=0.043) but positively correlated with EWL% (r=0.284, P<0.001) . The multivariate linear regression analysis showed that postoperative stomachache (β=-0.239, P=0.002) and postoperative fatigue (β=-0.169, P=0.025) were factors that affect PCS scores; ΔALT (β=-0.181, P=0.017) and postoperative fatigue (β=0.171, P=0.024) were factors that affect MCS scores; EWL% (β=-0.188, P=0.010) , ΔBM% (β=-0.146, P=0.047) , ΔALT (β=0.219, P=0.003) and postoperative fatigue (β=0.169, P=0.022) were factors that affect CPSS scores; ΔALT (β=-0.254, P=0.001) and acid reflux (β=-0.251, P=0.001) were factors that affect GWS scores; ΔBMI (β=-0.245, P=0.010) , EWL% (β=0.247, P=0.003) and ΔBF% (β=-0.366, P<0.001) were factors that affect satisfaction of surgery. Among the 96 patients with preoperative comorbidities, multiple linear regression analysis showed that postoperative relief of comorbidities (β=0.411, P<0.001) and stomachache (β=-0.192, P=0.040) were factors that affect PCS scores; ΔALT (β=-0.273, P=0.006) and acid reflux (β=-0.263, P=0.008) were factors that affect MCS scores; postoperative relief of comorbidities (β=-0.220, P=0.024) , ΔALT (β=0.301, P=0.002) , stomachache (β=0.214, P=0.023) and ΔVSF (β=0.212, P=0.031) were factors that affect CPSS scores; postoperative relief of comorbidities (β=0.290, P=0.002) , ΔALT (β=-0.310, P=0.001) and stomachache (β=-0.271, P=0.004) were factors that affect GWS scores; postoperative relief of comorbidities (β=0.402, P<0.001) , ΔBF% (β=-0.452, P<0.001) and ΔBMI (β=-0.364, P<0.001) were factors that affect satisfaction of surgery.

Patients' BMI decreased significantly one year after bariatric surgery. The postoperative acid reflux, stomachache, fatigue and the increase of ΔBF% and ΔALT negatively affect patients'psychological status; the increase of EWL% and ΔBM% positively affect patients'psychological status. For patients with comorbidities, the higher the degree of postoperative comorbidity remission, the greater the positive impact on the patient's psychological status.

The mental health of trainees receiving the three-year standardized general practice residency program (SGPRP) has been valued recently, and psychological problems are considered to be one major type of causes of their failure to complete the full training. So understanding the mental health status and associated factors of psychological problems in these GP trainees are of important significance for the development of residency training policies and programs.

To explore the mental health status and causes of psychological problems in GP trainees of SGPRP, improving the attention of SGPRP managers and the society given to the mental health of GP trainees.

This was a mixed-method sequential explanatory study. In January 2021, by use of convenience sampling, all in-service GP trainees of SGPRP were recruited from Peking University Shenzhen Hospital to attend a self-administered survey to complete the Demographic Questionnaire compiled by our research team and the Symptom Checklist 90 (SCL-90) . The total score and domain scores of the SCL-90 were analyzed overall, then were compared among the trainees by grade. For understanding the main life events triggering emotional or psychological problems and their associations with residency training program or specialty, and GP trainees' preferred assistance as well as suggestions for the development of SGPRP, from February to June 2021, purposive and heterogeneous sampling were used to recruit GP trainees with mental health assessment to attend an in-depth, semi-structured interview using phenomenological research procedure. The interview results were recorded, and transcribed, then coded using NVivo 12, and analyzed using Colaizzi's seven-step analysis and thematic analysis.

All GPs (n=84) responded to the survey, with a 100% response rate. The mean total SCL-90 score and the mean total symptom index for 84 GP trainees were (149.61±50.55) , and (1.66±0.56) , respectively. Of them, 29 (34.5%) had a total score≥160. The prevalence of obsessive-compulsive, depression, interpersonal sensitivity, anxiety, paranoid ideation, anger-hostility, psychoticism, somatization and phobic-anxiety (prevalence of symptoms in each domain was defined as domain score≥2) was 53.6% (45/84) , 39.3% (33/84) , 34.5% (29/84) , 26.2% (22/84) , 22.6% (19/84) , 21.4% (18/84) , 19.0% (16/84) , 14.3% (12/84) , and 14.3% (12/84) , respectively. The depression domain score varied significantly across GP trainees by grade (P<0.05) . The prevalence of depression was 48.4% (15/31) in grade 2 GP trainees. In total, 21 GP trainees attended the interview, 14 (66.7%) of whom had a total SCL-90 score≥160. Four themes emerged from the analysis: impact of personal problems on psychological status; harm and benefits caused by interpersonal interactions at work; psychological stress related to the residency base; lack of confidence related to specialty choice.

The high prevalence of psychological problems in GP trainees may be closely related to personal factors and problems encountered during residency training. In view of this, psychological guidance and crisis intervention should be listed as an important part of residency training management, and efforts should be made to enhance the trainees' sense of existence and belonging as well as self-confidence, thereby helping them to successfully complete the training.

The elderly population in our country is large and growing rapidly, and depression is a common emotional disorder and mental health problem among the elderly population. The mental health of the female elderly population is increasingly becoming a focus of social concern.

To explore the influencing factors of depression symptoms in the female elderly population from a multi-level and comprehensive perspective of health ecology, and provide theoretical basis for identifying and intervening in depression symptoms in the elderly female population in China.

In January 2024, we extracted for the 2020 survey data from the China Health and Retirement Longitudinal Survey (CHARLS), and a group of female elderly adults aged 60 years and above were selected for the study (n=4 594). Based on the health ecology model, the influencing factors were divided into five levels: personal characteristics layer, behavioural characteristics layer, interpersonal network layer, living and working conditions layer, and policy environment layer. The χ² test and binary Logistic regression model were used to explore the influencing factors of depression symptoms and to establish a health ecology model of depression symptoms in the Chinese female elderly population.

The detection rate of depression symptoms in the Chinese female elderly population was 48.06% (2 208/4 595). Logistic regression analysis showed that age of ≥80 years (OR=0.601, 95%CI=0.449-0.804), sleep duration of≥6 h (OR=0.561, 95%CI=0.493-0.639), satisfaction with life (OR=0.256, 95%CI=0.199-0.330), better self-rated physical health (OR=0.459, 95%CI=0.395-0.533), urban household registration (OR=0.717, 95%CI=0.603-0.853), satisfaction with children (OR=0.666, 95%CI=0.472-0.940), education level of junior high school and above (OR=0.712, 95%CI=0.582-0.871), family income >50 000 yuan (OR=0.822, 95%CI=0.704-0.959) and the per capita GDP of the city is 50 000 to 100 000 yuan (OR=0.841, 95%CI=0.730-0.970) were the protective factors for the development of depression symptoms in the Chinese female elderly population (P<0.05). Having become disabled (OR=1.786, 95%CI=1.556-2.050), suffering from chronic diseases (OR=1.159, 95%CI=1.014-1.324), central region (OR=1.298, 95%CI=1.107-1.522) and western region (OR=1.407, 95%CI=1.183-1.675) were the risk factors for depression symptoms in the Chinese female elderly population (P<0.05) .

The detection rate of depression symptoms in the Chinese female elderly population is relatively high, and there are many influencing factors, including: age in the personal characteristics layer; sleep time, satisfaction with life, self-related of physical health, disability, and chronic disease in the behavioral characteristics layer; household registration type, satisfaction with children, and geographical distribution in the interpersonal network layer; education and family income in the living and working conditions layer; the per capita GDP of the city in the policy environment layer. Effective intervention measures should be taken at all layers, targeting key populations, in order to reduce the incidence of depression symptoms among the Chinese elderly women.

The relationship between fatigue and diseases continues to receive widespread attention and fatigue is becoming an important public health issue. The World Health Organization added overexertion to the International Classification of Diseases in May, 2019, which had took effect globally in 2022. The concept of chronic fatigue syndrome (CFS) was proposed earlier, while its etiology and pathogenesis still remain unclear till now, resulting in lacking of specific therapies, which may be due to the involvement of multiple systems and the difficulties in distinguishing CFS symptoms from anxiety/depression, the complexity of the diagnosis and treatment of the disease and researches on it are also increased. This review initially investigates the characteristics of CFS associated with anxiety/depression, further explores the similarities and differences in indicator change characteristics between CFS and anxiety/depression in terms of the current research status on biological indicators, imaging abnormalities and treatment, in order to provide new ideas for the diagnosis and typing of CFS, and provide suggestions for conducting clinical and basic researches on the disease.

The recurrence rate of late-life depression is high, however, there is a lack of research on intervention protocol to prevent recurrence of late-life depression at home and abroad.In the early stage, the research group explored the risk factors for recurrence of late-life depression, and the controllable risk factors were poor medication compliance, less physical activity, and less eating.

To search, evaluate and summarize the evidence related to the prevention of recurrence of late-life depression based on the above three risk factors.

In October 2022, the evidences related to the prevention of recurrence of late-life depression were searched in Web of Science, PubMed, Cochrane Library, American Guide Network, British Guidebook, Website of Registered Nurses Association of Ontario (RNAO), Evidence-based Nursing Center of Fudan University, CNKI and other databases from inception to October 2022, which include guidelines, systematic reviews, expert consensuses, evidence summaries, etc. The quality of the included guidelines, systematic reviews, expert consensuses and original researches were evaluated by investigators trained in systematic evidence-based medicine using the Appraisal of Guidelines for Research & EvaluationⅡ (AGREEⅡ) Instrument, AMSTAR, and the Australian Joanna Briggs Institute (JBI) evidence-based center evaluation standards (2016 version), respectively. Finally, the 2014 Australian JBI evidence-based health care center evidence grading and recommendation level system was used to summary, evaluate and grade the evidence.

A total of 15 articles were included, including 3 guidelines, 11 systematic reviews and 1 RCT. The qualities of the 3 guidelines were graded as B or above, the qualities of 11 systematic reviews were graded as medium or above, and the quality of 1 RCT was graded as B. A total of 24 best evidence items were summarized from 6 aspects of intervention evaluation, diets and nutrition, exercise and rehabilitation training, psychosocial interventions, medication compliance, and effect evaluation.

The study summarizes the best evidence for prevention of late-life depression, suggesting that clinical staff should comprehensively evaluate the patients, and develop individualized intervention program focus on evaluation, diets and nutrition, exercise and rehabilitation training, medication compliance guidance, and psychosocial interventions, combining with the characteristics of patients and diseases.

Test anxiety disorder is a group of symptoms related to stress caused by tests, exams, evaluations, and others. It is among the severe psychological problems in exams. Long-term test anxiety is likely to cause tension, fear, irritability, depression, and other negative emotions, and it disturbs working memory, attention, and other cognitive abilities and even leads to suicidal ideation. In order to standardize the clinical diagnosis and treatment of test anxiety disorder, under the organization of the Test Anxiety Disorder Collaboration of the Chinese Society of Psychosomatic Medicine, this expert consensus was formulated by 13 experts in the field of psychiatry and psychology. We collaborate and announce the expert consensus based on current research and clinical experience. We hope the consensus can provide clinicians with scientific and comprehensive guidance on test anxiety disorder, including epidemiology, etiology, clinical manifestations, evaluation, and treatment.

Population aging in China is deepening, and the widowed rate of the elderly is also on the rise. Widower is one of the most stressful events in the human life course, and its impact also affects the mental health and economic level of widower. In many studies on the impact of widower on the mental health of the elderly at home and abroad, the proxy variables used are traditional indicators, such as subjective well-being, loneliness, depression level, and some studies do not consider the endogeneity between widowhood and health status.

To evaluate the impact of widowhood on the mental health of older adults in China, and provide a basis and reference for formulating the mental health intervention program for older adults in China.

Using the 2018 China Health and Retirement Longitudinal Study (CHARLS) as the data source, 4 694 older adults aged 60 years and above were selected as study subjects and divided into the widowed group (n=644) and non-widowed group (n=4 050) . The mental frailty index was used as a perspective for evaluating the mental health status of older adults. Using propensity score matching (PSM) model, the propensity score was calculated by using Logit regression analysis, the robustness was tested by using standard deviation variation, common support bar graph and nuclear density distribution, the impact of widowhood on the physical and mental health of older adults was analyzed by using K-nearest neighbor matching, radius matching and kernel matching, and the heterogeneity was tested based on gender, household type and age.

Compared to the non-widowed group, the mental health of older adults in the widowed group was impaired (P<0.05) . Logit regression model results showed that female (OR=2.274, 95%CI=1.917-2.698) , age (OR=0.975, 95%CI=0.972-0.978) , secondary education level (OR=0.618, 95%CI=0.505-0.756) and monthly family consumption (OR=1.000, 95%CI=1.000-1.000) were correlated with widowhood (P<0.05) . The robustness test results after matching were better. The results of PSM showed that widowhood significantly increased the mental frailty index level (ATT ranged from 0.054 to 0.055, P<0.05) . The results of heterogeneity test showed that there were significant differences between urban and rural areas and among different age groups in the impact of widowhood on the mental frailty index of older adults, but there was no significant difference between male and female in the impact of widowhood on the mental frailty index of older adults. Among them, the impact of widowhood on the older adults in rural areas was more significant (ATT ranged from 0.072 to 0.075, P<0.05) , but the impact on older adults in urban areas was not significant; the impact on older adults in the low age group and high age group was more significant (ATT ranged from 0.061 to 0.081, P<0.05; 0.067-0.078, P<0.05) , but the impact on older adults in the middle age group was not significant.

Widowhood has a negative impact on the mental health of the older adults. The impact varies among different older adults. The widowed older adults in rural areas, just entering old age and in their later years need attention and psychosocial support.

A large body of literature suggests that plasma cytokine levels are associated with symptoms in patients with schizophrenia, but the relationship of plasma cytokines with depressive symptoms, which often occur in the late stage of schizophrenia, still needs to be explored.

To explore the relationship between plasma cytokine levels and depressive symptoms in schizophrenic patients.

Patients with stable schizophrenia were selected from Department of Psychiatry of three hospitals (Chaohu Hospital Affiliated to Anhui Medical University, Hefei Fourth People's Hospital, and Maanshan Fourth People's Hospital) from May to December 2018. The Calgary Depression Scale for Schizophrenia (CDSS) was used to evaluate the depressive symptoms, and the total score of CDSS≥5 was defined as depression. The plasma levels of interleukin (IL) -1β, IL-2, IL-6 and IL-17A were detected by flowcytometry. Spearman rank correlation analysis and multiple linear regression analysis were used to analyze the relationship between plasma cytokine and depression in stable schizophrenia.

A total of 111 patients with stable schizophrenia were included, with depression prevalence of 28.83% (32/111). Spearman rank correlation analysis showed that the total score of CDSS was positively correlated with the level of plasma IL-1β, IL-2 or IL-17A (r_s=0.507, 0.466, 0.374, P<0.05). Multiple linear regression analysis showed that higher level of plasma IL-17A was associated with decreased of risk of depression in stable schizophrenia (B=-0.125, P<0.05), and longer duration of schizophrenia was associated with increased of risk of depression in stable schizophrenia (B=0.343, P<0.05) .

Higher level of IL-17A and longer duration of schizophrenia may be correlated with depression in stable schizophrenia.

Considerable evidence suggests that people with depressive disorder are at higher risk for somatic symptoms than normal people, but the mechanisms of susceptibility are unclear. Some studies suggest that the levels of precursor of brain-derived neurotrophic factor (ProBDNF) and inflammatory cytokines in depressive disorder patients are higher, but it is still unclear whether this is related to the accompanying somatic symptoms.

To explore the characteristics of somatic symptoms, and their correlations with BDNF and inflammatory cytokines in patients with major depressive disorder (MDD) .

A total of 59 MDD outpatients and inpatients from Mental Health Department, First Hospital of Shanxi Medical University and 32 healthy volunteers from the community were recruited from February 2019 to December 2020. Somatic symptoms were diagnosed using the Somatic Self-rating Scale (SSS, SSS score >36 and SSS score ≤36 were defined as with somatic symptoms or without, respectively) . Depression was assessed using the Hamilton Depression Rating Scale (HAMD-17) . Clinical data were collected, including gender, age, years of education, HAMD-17 score, SSS score, absorbance of ProBDNF and BDNF, and inflammatory cytokines (CRP, IL-4, IL-10, IL-18, IL-23a, HMGB1, IL-6, TNF-α, IFN-α) . Spearman's rank correlation analysis was used to investigate the correlation of somatic symptoms (including dizziness and headache, frequent and urgency of urination, cardiovascular symptoms, muscle soreness, gastrointestinal symptoms, tingling and twitching of hands and feet, choking and sighing, blurred vision, and discomfort of the throat) , SSS-S factor score and HAMD-17 score with ProBDNF and BDNF, and inflammatory cytokines.

MDD patients with somatic symptoms had higher total HAMD-17 score than those without (P<0.001) . Both MDD patients with and without somatic symptoms had higher total HAMD-17 score than healthy volunteers (P<0.001) . MDD patients with somatic symptoms had higher total SSS score and SSS-S factor score than those without (P<0.001) . And they also had higher total SSS score and SSS-S factor score than healthy volunteers (P<0.001) . MDD patients with somatic symptoms had higher BDNF than those without (P<0.05) . The IFN-α in healthy volunteers was lower than of MDD patients with or without somatic symptoms (P<0.001) . ProBDNF was negatively correlated with muscle soreness (r_s=-0.262, P<0.05) . CRP was negatively correlated with tingling and twitching of hands and feet (r_s=-0.386, P<0.01) . IL-4 had a negative correlation with gastrointestinal symptoms (r_s=-0.336, P<0.01) . IL-10 had a positivecorrelation with blurred vision (r_s=0.286, P<0.05) . BDNF was positively correlated with dizziness and headache (r=0.339, P<0.01) , cardiovascular symptoms (r_s=0.309, P<0.05) , gastrointestinal symptoms (r_s=0.278, P<0.05) , muscle soreness (r_s=0.419, P<0.01) , tingling and twitching of hands and feet (r_s=0.286, P<0.05) , choking and sighing (r_s=0.372, P<0.01) , discomfort of the throat (r_s=0.392, P<0.01) and SSS-S factor score (r_s=0.418, P<0.01) . IL-6 was positively correlated with cardiovascular symptoms (r_s=0.283, P<0.05) and choking and sighing (r_s=0.374, P<0.01) . TNF-α was negatively correlated with muscle soreness (r_s=-0.299, P<0.05) . IFN-α showed a negative correlation with blurred vision (r_s=-0.267, P<0.05) .

The peripheral blood IFN-α of MDD patients was lower than that of normal people. The severity of depression and BDNF level were higher in MDD patients with somatic symptoms than those without. The elevation of multiple inflammatory cytokines was correlated with the increase in the risk of somatic symptoms, suggesting that patients with MDD may be prone to somatic symptoms and adverse outcomes, requiring early intervention.

Depressed adolescents with childhood trauma often present with more severe symptoms and are insensitive to drugs. Eye movement desensitization and reprocessing (EMDR) plays a unique role in the treatment of trauma-related mental disorders. It has been gradually used in the treatment of depression and has achieved certain results recently, but there are few related studies in China.

To assess whether EMDR has better efficacy than sertraline in the treatment of depressed adolescents with childhood trauma using a comparative analysis, providing scientific evidence for further promoting clinical application of EMDR.

Sixty depressed adolescents with childhood trauma were recruited from Psychological Clinic, Affiliated Hospital of Zunyi Medical University from December 2020 to February 2022, and equally randomized into a sertraline group and an EMDR group. Sertraline group received a eight-week treatment with sertraline: the dose was 50 mg/d in the first week and gradually increased to 100 mg/d in the second week, and could be increased to 200 mg/d at the end of the fourth week if the patients had negative ideas or self-injurious behavior. The EMDR group received EMDR treatment, once a week, for a total of 8 weeks. The Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Connor-Davidson Resilience Scale (CD-RISC) were used to evaluate the psychological status of the two groups before treatment, four weeks and eight weeks after treatment.

Except for five dropouts, the remaining cases who completed the trial were finally included, including 28 in the sertraline group and 27 in the EMDR group. The treatment type and treatment duration had interactive effects on the BDI, BAI and CD-RISC scores of the two groups (P<0.05). The treatment duration had significant main effects on the BDI, BAI and CD-RISC scores of the two groups (P<0.05). The treatment type had significant main effects on BAI and CD-RISC scores of the two groups (P<0.05), but produced no significant effects on the BDI scores (P>0.05). EMDR group had higher average CD-RISC score than sertraline group at four weeks after treatment (P<0.05). EMDR group had higher average CD-RISC score, and lower average BDI and BAI scores than sertraline group at eight weeks after treatment (P<0.05). In the sertraline group, the average BDI score at eight weeks after treatment was much lower than that at baseline or four weeks after treatment (P<0.05), the BDI score after 4 weeks of sertraline treatment was lower than that before treatment (P<0.05), and the average BAI score at eight weeks after treatment was much lower than that at basetime (P<0.05). In the EMDR group, the average BDI and BAI scores decreased significantly while the average CD-RISC score increased significantly at both four and eight weeks after treatment compared with baseline levels (P<0.05). And compared with four-week treatment, eight-week treatment lowered the average BDI and BAI scores more significantly, and increased the average CD-RISC score more significantly (P<0.05) .

Sertraline could partially improve depression and anxiety in depressed adolescents with childhood trauma, but had no significant improvement of psychological elasticity. In contrast, EMDR could effectively improve the depression and anxiety as well as psychological elasticity, so it could be used as the preferred treatment.

As the second most serious disease worldwide, the etiology and pathogenesis of depression have not been clearly defined. Depression treatment faces a bottleneck, due to limitations of common therapies, such as side effects associated with drug therapy and high risk of recurrence after drug therapy, high requirements for clinicians to perform psychotherapy, and high cost of modalities and disorientation in physical therapy. Transcranial low-level laser, a new therapy has recently proven to be effective in scientific research and clinical antidepressant treatment, utilizes low-level laser non-invasively passing through the skull without causing damage to regulate biological tissues and protect neurons. Even though the molecular and cellular mechanisms underlying the therapy for depression are not yet clear, this non-drug therapy could be highly promising for depression treatment.

Psychological capital (PsyCap) has a significant impact on individual attitude, behavior, and performance. Currently, studies on the level and associated factors of PsyCap among general practitioners (GPs) are limited.

To investigate the level of PsyCap and its associated factors among community GPs in China, providing evidence for human resource management in primary health care.

To conduct the questionnaire survey, 40 community health service institutions from their list of community health service institutions were randomly chosen, 4 632 GPs (40% of whom were on duty) were randomly selected from each community health service institution's duty roster on the day of the survey, and all five provinces (autonomous, municipalities) regions in the east, central, and west China were chosen by use of multi-stage stratified random sampling between March and May 2021. The questionnaire consisted of 3 sections: general information, workplace violence, and PsyCap, and statistical analysis was performed using general descriptive analysis, rank sum test, and generalized linear regression.

A total of 4 376 community GPs were finally included as eligible respondents. The total median score and average total score of PsyCap were 104 (20) and 4.33 (0.83), higher than the theoretical median (3.50 points). The region〔central China (b=1.355) 〕, age〔40~49 (b=2.609), ≥50 (b=4.035) 〕, marital status〔married (b=1.801) 〕, practice setting〔rural (b=2.088) 〕, holding an administrative post〔no (b=-1.734) 〕, weekly working hours〔>50 (b=2.743) 〕, average number of daily consultations〔20~39 (b=2.177) 〕, workload〔moderate (b=6.900), high (b=8.146) 〕, occupational stress〔moderate (b=-6.936), high (b=-10.309) 〕, occupational development opportunities〔general (b=2.073), more (b=7.747) 〕, and the frequency of workplace violence〔low (b=-3.132), medium (b=-3.990), high (b=-7.033) 〕were factors associated with the level of PsyCap among GPs significantly (P<0.05) .

The PsyCap of community GPs in China is at an upper medium level, and the associated factors are complicated. To improve the level of PsyCap among GPs, attention should be paid to their mental health status, and provide them with interventions targeting PsyCap-related factors to lessen the GPs' stress.

With the increase of the aging population, age-related health problems have garnered increasing attention. Compared to physiologic diseases with significant clinical symptoms, the mental health issues of the elderly are often overlooked. The underlying depressive states and high incidence of chronic diseases collectively contribute to a decline in quality of life in old age. Moreover, metabolic diseases, more prevalent in the elderly, significantly impact brain health, potentially leading to neurological damage and cognitive decline.

This study aims to investigate the relationship between depression, cognitive status, and nutritional and metabolic status among elderly individuals in the community.

We selected 3 767 elderly individuals who participated in physical examinations at the Youyi Street Community Health Service Center in Baoshan District, Shanghai. The demographic data on sex, age, BMI and waist-to-hip ratio were collected. The evaluations included the Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), Mini Nutritional Assessment (MNA), and Activities of Daily Living Scale (ADL). Metabolic syndrome-related diseases and the 10-year cardiovascular disease risk were assessed using clinical metabolic indicators, and Pearson correlation analysis was used to explore the correlations among these indicators.

This research showed that significant differences were found in age, MNA, MMSE scores, the proportion of people at high risk of cardiovascular disease and the 10-year cardiovascular disease risk grade among the different groups (P<0.05). Correlation analysis indicated that the GDS score was negatively correlated with the total MMSE score and its sub-item scores, except for the repetition ability score. MNA and ADL were positively correlated with the total MMSE score (P<0.05). Additionally, GLU and HbA_1c levels were negatively correlated with immediate recall ability in the MMSE (P<0.05) .

Our findings suggest that depression in the elderly is associated with cognitive decline, while better nutritional status is linked to improved cognitive performance. Focusing on and improving metabolic health in the elderly may enhance their mental state and overall mental health.

The period of junior high school age is a key development stage of adolescent mental health, during which mental maturity and physical and mental development imbalance may greatly increase the susceptibility of the students to depressed mood. Previous studies have shown that yin-deficiency constitution is a risk factor for depressed mood in adolescents, which has also been reported to be impacted by stressful life events and the time taken to fall asleep, but there is no systematic discussion about the mechanism of action in the relationships between the four factors.

To explore the relationship between yin-deficiency constitution and depressed mood in junior high school students, as well as the mediating effect of stressful life events and the time taken to fall asleep.

On March 2022, a convenient sample of junior high school students from a middle school in Meishan City, Sichuan Province were surveyed on their general data (gender, ethnicity, region of origin, grade), prevalence of yin-deficiency constitution assessed using the yin-deficiency Constitution subscale of the Traditional Chinese Medicine Constitution Scale for 7-14-year-olds, prevalence of stressful life events assessed using the Adolescent Self-Rating Life Events Checklist (ASLEC), and the time taken to fall asleep assessed using the items assessing how long it takes to fall asleep in the Munich Chronotype Questionnaire (MCTQ), and prevalence of depressed mood assessed using the Center for Epidemiologic Studies Depression (CES-D). The scores of yin-deficiency constitution, ASLEC and CES-D as well as the time taken to fall asleep were compared across the students by demographic characteristics. Spearman correlation analysis was used to explore the correlation between the variables. A multiple-mediator model was constructed to examine the mediating effect of stressful life events and the time taken to fall asleep on yin-deficiency constitution and depressed mood, and the significance of chain mediating effect was tested using bootstrap method.

The survey achieved a response rate of 98.1% (2 570/2 620) in the 2 620 surveyed students. The detection rate of depressed mood in the respondents was 32.8% (844/2 570). Female students had higher scores of yin-deficiency constitution, ASLEC and CES-D than male students (P<0.05). The yin-deficiency score, ASLEC score and CES-D score in grade 2 and grade 3 students was higher than that of grade 1 students (P<0.05). The ASLEC score in non-Han students was longer than that of Han students (P<0.05). The time taken to fall asleep in Han students was longer than that of non-Han students (P<0.05). The yin-deficiency constitution score, ASLEC score and CED-S score of students from rural areas was higher than that of those from towns (P<0.05). The average yin-deficiency constitution score, ASLEC score, the time taken to fall asleep and CES-D score in all respondents were 25.0 (15.0, 40.0) points, 36.0 (30.0, 44.0) points, 15.0 (8.6, 25.7) min and 11.0 (6.0, 18.0) points, respectively. The yin-deficiency constitution score was positively correlated with ASLEC score, the time taken to fall asleep and CES-D score (r_s=0.538, 0.151, 0.470, P<0.05). The ASLEC score was positively correlated with the time taken to fall asleep and CES-D score (r_s=0.224, 0.684, P<0.05). The time taken to fall asleep was positively correlated with CES-D score (r_s=0.289, P<0.05). Multiple mediator model-based analysis showed that yin-deficiency constitution positively predicted depressed mood (β=0.465, P<0.001). And it also positively predicted the level of stressful life events (β=0.511, P<0.001) and the time taken to fall asleep (β=0.066, P=0.004). The level of stressful life events positively predicted the time taken to fall asleep (β=0.228, P<0.001) and depressed mood (β=0.591, P<0.001). The time taken to fall asleep positively predicted depressed mood (β=0.139, P<0.001). The final results of Bootstrap test showed that significant effect of path dependence was found in the path of yin-deficiency constitution→stressful life events→the time taken to fall asleep→depressed mood〔mediating effect value =0.009, 95%CI (0.006, 0.012), P<0.001〕, indicating that the chain mediating effect of stressful life events and the time taken to fall asleep on yin-deficiency constitution and depressed mood was valid.

Yin-deficiency constitution can be used as a direct predictor of depressed mood in junior high school students, but it also can directly affect their depressed mood through its role played between stressful life events and the time taken to fall asleep as an independent mediator or a chain mediator. To reduce the incidence of depressed mood and improve mental health in this population, measures can be taken to improve the yin-deficiency constitution, improve the ability to cope with stressful life events and shorten the time taken to fall asleep.

As China enters a moderately aging society, the mental health problems of the elderly are increasing year by year, and lifestyle habits are closely related to the mental health of the elderly.

Exploring the relationship between nap time, nighttime sleep, and depressive symptoms among elderly people in China, and determining recommended sleep time based on lifestyle habits, providing scientific basis for early prevention and control of depression in the elderly.

Based on the publicly released fifth round (2020) of the China Health and Retirement Longitudinal Study (CHARLS) on November 16, 2023, 8 233 eligible individuals were included as research subjects. The Depression Rating Scale (CSE-D10) was used to assess depressive symptoms in elderly individuals, with nap duration divided into 5 levels: no nap, <30 min, 30-59 min, 60-89 min, ≥90 min. Nighttime sleep was divided into 5 levels: ≥8 h, 7-<8 h, 6-<7 h, 5-<6 h, <5 h. Multivariate Logistic regression analysis was used to explore the factors that affect the occurrence of depression symptoms in elderly people. Random forest model was used to analyze the importance of nap duration and nighttime sleep in the occurrence of depression symptoms in elderly people. Restrictive cubic spline curves were used to further explore the dose-response relationship between nap duration, nighttime sleep duration, and the risk of depression symptoms.

During the 2020 survey period, the incidence of depressive symptoms among elderly people in China was 24.84% (2 045/8 233) . The results of multivariate Logistic regression analysis showed that a nap duration of 30-59 minutes was a protective factor for depression symptoms in the elderly (OR=0.814, 95%CI=0.673-0.985, P=0.034) , and a nighttime sleep duration of less than 5 hours was a risk factor for depression symptoms in the elderly (OR=1.705, 95%CI=1.435-2.027, P<0.001) . Women, unmarried/separated/divorced/widowed, disabled, physically painful, physically active, self-rated health status decreased, life satisfaction decreased, stroke, and Parkinson's disease increased the risk of depression symptoms in the elderly (P<0.05) . The random forest model showed that the duration of nap time and nighttime sleep time had a significant impact on depressive symptoms. There was a non-linear relationship between the duration of nap time and the occurrence of depressive symptoms (P_nonlinear<0.05) . The risk of depression in elderly people continued to decrease with increasing time after nap time of 30 minutes, with the lowest level being about 50 minutes. The risk of depression symptoms increased after nap time exceeded 75 minutes. The risk of depression in elderly people decreased continuously with time after 6 hours of sleep at night, with a minimum level of about 7 hours. The risk of depression increased after more than 9 hours of sleep (P_overall<0.05) .

The incidence of depression (24.84%) is higher in the elderly population in China, and there is a J-shaped relationship between the duration of nap time and nighttime sleep and depression. It is recommended that elderly people nap for 30-75 minutes every day, and moderate nap time can effectively reduce the risk of depression symptoms in the elderly. At the same time, sleeping for 6-9 hours at night can reduce the risk of depression symptoms, which has certain significance for early prevention and control of depression in the elderly population.

Postpartum depression and personality problems have adverse effects on maternal and infant health. At present, the research results on the relationship between different personality traits and postpartum depression are still controversial, and there is a lack of the systematic reviews on it in China.

To systematically review the relationship between different personality traits and postpartum depression.

The research was performed Web of Science, PubMed, EBSCOhost, Embase, PsycInfo (Proquest) , CNKI, Wanfang Data Knowledge Service Platform, and VIP for studies on the relationship between different personality traits and postpartum depression from inception until June 4, 2021. The relevant data extraction was conducted after the quality evaluation of literature. Stata 16.0 was used for meta-analysis. Subgroup analysis and publication bias tests were performed for the relationship between neuroticism and postpartum depression. Sensitivity analysis of the relationship between different personality traits and postpartum depression was performed using rollover effect models.

A total of 19 articles and 9 personality traits were finally included in the meta-analysis, including neuroticism (14 studies) , extraversion (6 studies) , agreeableness (5 studies) , openness (4 studies) , conscientiousness (4 studies) , vulnerability (3 studies) , obsessive-compulsive personality disorder (2 studies) , avoidant personality disorder (2 studies) and dependent personality disorder (2 studies) . The result of Meta-analysis showed that neuroticism 〔OR=1.30, 95%CI (1.20, 1.40) 〕, vulnerability 〔OR=1.39, 95%CI (1.10, 1.76) 〕, avoidant personality 〔OR=6.27, 95%CI (2.55, 15.40) 〕and dependent personality 〔OR=7.11, 95%CI (1.62, 31.14) 〕 were risk factors of postpartum depression (P<0.05) . Extraversion 〔OR=0.86, 95%CI (0.77, 0.97) 〕 and openness 〔OR=0.94, 95%CI (0.90, 0.98) 〕 were protective factors of postpartum depression (P<0.05) . The results of the subgroup analysis showed that the different threshold value of Edinburgh Postnatal Depression Scale (EPDS≥12 scores: OR=1.71, EPDS≥9 scores: OR=1.14, P=0.028) and different investigation time of postpartum depression (OR=1.13 for <1 week postpartum, OR=1.33 for 2-12 weeks postpartum, OR=2.22 for ≥13 weeks postpartum; P=0.008) were the sources of heterogeneity in the pooled results. Sensitivity analysis showed that the pooled results about personality traits were reliable except for obsessive-compulsive personality disorder.

Personality traits have different effects on postpartum depression, among which neuroticism and vulnerable personality are risk factors of postpartum depression, extraversion and openness are protective factors of postpartum depression. Postpartum depression may be more severe and more likely to occur after 13 weeks postpartum in postpartum women with neuroticism. Due to the inconsistent results of domestic and foreign researches, the relationships between avoidant, dependent, and obsessive-compulsive personality disorders and postpartum depression need to be further explored in the future.

With the population aging, mental health of the middle-aged and elderly adults is of great concern, especially in middle-aged and elderly women. Compared with urban women, rural women are more likely to suffer from mental diseases due to their poorer health status, lower education level and backward living conditions, however, the accessibility of mental health services among them is low.

To understand the prevalence of depression among middle-aged and elderly women in rural China and analyze its influencing factors, in order to provide empirical evidence for improving the mental health of middle-aged and elderly women.

From May to July 2021, the follow-up data of the 2018 China Health and Retirement Longitudinal Study (CHARLS) was extracted, and rural women aged 45 years and above were selected as the study subjects (n=6 736) . The scores of the simplified version of the Center for Epidemiologic Studies Depression Scale (CES-D) were used to determine the depression status of rural middle-aged and elderly women. Chi-square tests and multivariate Logistic regression model were used to analyze the influencing factors of the occurence of depressive symptoms among rural middle-aged and elderly women (including individual characteristics, health behaviors, social participation and utilization of medical services utilization) .

The CES-D score of 6 736 rural middle-aged and elderly women was (20.0±6.9) , 42.46% (2 860/6 736) of whom had depressive symptoms. The results of multivariate Logistic regression analysis showed that satisfication with health status〔OR (95%CI) =0.40 (0.36, 0.45) 〕, sleep duration ≥6 h〔OR (95%CI) =0.48 (0.43, 0.54) 〕, Internet use〔OR (95%CI) =0.63 (0.50, 0.80) 〕 and satisfication with life 〔OR (95%CI) =0.25 (0.21, 0.30) 〕 were correlated with lower risk of depression; hysical disability〔OR (95%CI) =1.41 (1.16, 1.71) 〕, suffering from chronic diseases〔OR (95%CI) =1.35 (1.21, 1.50) 〕, receiving outpatient services within 1 month〔OR (95%CI) =1.25 (1.09, 1.43) 〕 and hospitalization services within 1 year〔OR (95%CI) =1.31 (1.13, 1.52) 〕 were correlated with higher risk of depression.

Based on the results of this study, the depression status of middle-aged and elderly women in rural China is relatively severe and affected by individual characteristics, health behaviors, social participation, and the medical services utilization. It is recommended that governments and civil affairs departments at all levels pay close attention to the mental health of rural middle-aged and elderly women, especially through the intervention and prevention from multiple dimensions such as health promotion and education, medical service quality, and accessibility of information, in order to promote the construction of healthy villages and process of health aging in China.