Research Progress of Lactylation in Age-related Diseases

doi:10.12114/j.issn.1007-9572.2024.0392

Abstract

Abstract:

Lactylation (Kla) is a novel mechanism of protein post-translational modification, which is formed by covalent coupling of lactate produced by glycolysis with lysine residues, mainly including histone lactylation and non-histone lactylation. At present, the study found that the main through regulating gene transcription and protein expression and subcellular localization to participate in the process of life activity in the cell. With the increasing of age, lactate metabolism in multiple organs of the body was disordered, and recent studies found that lactylation mediated by it could participate in the occurrence and development of a variety of age-related diseases. Therefore, this paper aimed to review the functional and mechanistic studies of lactylation in age-related diseases.

Key words: Lactylation, Lactic acid, Age-related diseases, Histone lactylation, Non-histone lactylation

摘要：

乳酸化修饰是由糖酵解产生的乳酸与赖氨酸残基共价耦联形成的一种新型的蛋白质翻译后修饰调控机制，主要包括组蛋白乳酸化和非组蛋白乳酸化修饰。目前，研究发现其主要通过调控基因转录和蛋白表达以及亚细胞定位来参与细胞内的生命活动过程。随着年龄的增加，机体内多器官的乳酸代谢紊乱，在近期研究中发现其介导的乳酸化修饰能够参与多种年龄相关性疾病的发生、发展。因此，本文旨在综述乳酸化修饰在年龄相关性疾病中的功能和作用机制。

关键词: 乳酸化修饰, 乳酸, 年龄相关性疾病, 组蛋白乳酸化, 非组蛋白乳酸化

CLC Number:

R 592

WU Miaomiao,LI Pengfei,XU Linhui, et al. Research Progress of Lactylation in Age-related Diseases[J]. Chinese General Practice, 2025, 28(35): 4501-4510. DOI: 10.12114/j.issn.1007-9572.2024.0392.
吴苗苗,李鹏飞,徐林慧等. 乳酸化修饰在年龄相关性疾病中的研究新进展[J]. 中国全科医学, 2025, 28(35): 4501-4510. DOI: 10.12114/j.issn.1007-9572.2024.0392.

Figures/Tables 1

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