General practice teaching clinic is an important training method to develop clinical thinking and improve general practice diagnosis and treatment ability of general practice residents. In this paper, we used a patient with fatigue as the main manifestation as a teaching case to introduce the Murtagh safe diagnostic strategy proposed by John Murtagh, a famous Australian general medicine expert, to inspire the diagnosis and differential diagnosis of fatigue for the general practice residents in the general practice teaching clinic: (1) What are the common diseases that cause fatigue? (2) What are the important diseases that should not be ignored? (3) What are the easily missed diseases of fatigue? (4) Are there underlying easily masked diseases? (5) Is there something the patient is not saying? Combined with the history, physical examination and laboratory findings, a preliminary diagnosis of antineutrophil cytoplasmic antibody-associated vasculitis causing rapidly progressive glomerulonephritis is highly probable. The timely referral got nephropathology which confirms the etiology of the fatigue was antineutrophil cytoplasmic antibody-associated glomerulonephritis, and achieved satisfactory outcome. Based on the Murtagh safe diagnostic strategy, the instructor helped the general practice residents to construct a systematic knowledge framework for the identification and analysis of fatigue, so as to improve their clinical logical thinking ability and the ability to solve practical clinical problems. Using the mind mapping as an auxiliary tool, the diagnosis and differential diagnosis of the Murtagh safe diagnostic strategy were concretized and visualized, so as to optimize the teaching effect.