Chinese General Practice ›› 2022, Vol. 25 ›› Issue (21): 2629-2634.DOI: 10.12114/j.issn.1007-9572.2022.0047
Special Issue: 儿科最新文章合辑; 脑健康最新研究合辑
• Original Research • Previous Articles Next Articles
Received:
2022-01-11
Revised:
2022-04-11
Published:
2022-07-20
Online:
2022-05-24
Contact:
Suzhen SUN
About author:
通讯作者:
孙素真
作者简介:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0047
组别 | 例数 | 性别(男/女) | 年龄分布 | ||
---|---|---|---|---|---|
≤3岁 | 4~6岁 | ≥7岁 | |||
非复发组 | 40 | 21/19 | 10(25.0) | 9(22.5) | 21(52.5) |
复发组 | 14 | 8/6 | 2(14.3) | 5(35.7) | 7(50.0) |
χ2值 | 0.090 | 1.253 | |||
P值 | 0.764 | 0.534 |
Table 1 Age and gender distribution of patients with anti-NMDAR encephalitis
组别 | 例数 | 性别(男/女) | 年龄分布 | ||
---|---|---|---|---|---|
≤3岁 | 4~6岁 | ≥7岁 | |||
非复发组 | 40 | 21/19 | 10(25.0) | 9(22.5) | 21(52.5) |
复发组 | 14 | 8/6 | 2(14.3) | 5(35.7) | 7(50.0) |
χ2值 | 0.090 | 1.253 | |||
P值 | 0.764 | 0.534 |
组别 | 例数 | 春季(3—5月) | 夏季(6—8月) | 秋季(9—11月) | 冬季(12、1—2月) |
---|---|---|---|---|---|
非复发组 | 40 | 10(25.0) | 15(37.5) | 10(25.0) | 5(12.5) |
复发组 | 14 | 4(28.6) | 3(21.4) | 4(28.6) | 3(21.4) |
χ2值 | 1.498 | ||||
P值 | 0.683 |
Table 2 Seasonal distribution of onset in children with anti-NMDAR encephalitis
组别 | 例数 | 春季(3—5月) | 夏季(6—8月) | 秋季(9—11月) | 冬季(12、1—2月) |
---|---|---|---|---|---|
非复发组 | 40 | 10(25.0) | 15(37.5) | 10(25.0) | 5(12.5) |
复发组 | 14 | 4(28.6) | 3(21.4) | 4(28.6) | 3(21.4) |
χ2值 | 1.498 | ||||
P值 | 0.683 |
项目 | 非复发组(n=40) | 复发组(n=14) | χ2(t)值 | P值 |
---|---|---|---|---|
发热〔n(%)〕 | 12(30.0) | 7(50.0) | 1.048 | 0.306 |
头痛/头晕〔n(%)〕 | 5(12.5) | 2(14.3) | <0.001 | 1.000 |
视物不清〔n(%)〕 | 1(2.5) | 0 | <0.001 | 1.000 |
癫痫发作〔n(%)〕 | 24(60.0) | 9(64.2) | 0.080 | 0.777 |
全面性癫痫发作〔n(%)〕 | 18(45.0) | 7(50.0) | 0.104 | 0.747 |
癫痫持续状态〔n(%)〕 | 10(25.0) | 4(28.6) | <0.001 | 1.000 |
运动障碍〔n(%)〕 | 20(50.0) | 7(50.0) | <0.001 | 1.000 |
精神行为异常〔n(%)〕 | 17(16.3) | 5(35.7) | 0.198 | 0.657 |
语言障碍〔n(%)〕 | 16(40.0) | 5(35.7) | 0.080 | 0.777 |
不自主运动〔n(%)〕 | 11(27.5) | 5(35.7) | 0.057 | 0.811 |
意识水平下降〔n(%)〕 | 11(27.5) | 4(28.6) | <0.001 | 1.000 |
睡眠障碍〔n(%)〕 | 9(22.5) | 4(28.6) | 0.009 | 0.925 |
认知功能障碍〔n(%)〕 | 5(12.5) | 5(35.7) | 2.325 | 0.127 |
自主神经功能障碍〔n(%)〕 | 9(22.5) | 1(7.1) | 0.763 | 0.382 |
起病时间( | 9.4±8.5 | 9.8±7.8 | -0.159a | 0.874 |
入院时mRS( | 2.0±0.8 | 2.6±0.9 | -2.428a | 0.019 |
Table 3 Analysis of clinical symptoms and signs in children with anti-NMDAR encephalitis
项目 | 非复发组(n=40) | 复发组(n=14) | χ2(t)值 | P值 |
---|---|---|---|---|
发热〔n(%)〕 | 12(30.0) | 7(50.0) | 1.048 | 0.306 |
头痛/头晕〔n(%)〕 | 5(12.5) | 2(14.3) | <0.001 | 1.000 |
视物不清〔n(%)〕 | 1(2.5) | 0 | <0.001 | 1.000 |
癫痫发作〔n(%)〕 | 24(60.0) | 9(64.2) | 0.080 | 0.777 |
全面性癫痫发作〔n(%)〕 | 18(45.0) | 7(50.0) | 0.104 | 0.747 |
癫痫持续状态〔n(%)〕 | 10(25.0) | 4(28.6) | <0.001 | 1.000 |
运动障碍〔n(%)〕 | 20(50.0) | 7(50.0) | <0.001 | 1.000 |
精神行为异常〔n(%)〕 | 17(16.3) | 5(35.7) | 0.198 | 0.657 |
语言障碍〔n(%)〕 | 16(40.0) | 5(35.7) | 0.080 | 0.777 |
不自主运动〔n(%)〕 | 11(27.5) | 5(35.7) | 0.057 | 0.811 |
意识水平下降〔n(%)〕 | 11(27.5) | 4(28.6) | <0.001 | 1.000 |
睡眠障碍〔n(%)〕 | 9(22.5) | 4(28.6) | 0.009 | 0.925 |
认知功能障碍〔n(%)〕 | 5(12.5) | 5(35.7) | 2.325 | 0.127 |
自主神经功能障碍〔n(%)〕 | 9(22.5) | 1(7.1) | 0.763 | 0.382 |
起病时间( | 9.4±8.5 | 9.8±7.8 | -0.159a | 0.874 |
入院时mRS( | 2.0±0.8 | 2.6±0.9 | -2.428a | 0.019 |
指标 | 未复发组(n=40) | 复发组(n=14) | t值 | P值 |
---|---|---|---|---|
白细胞(×106/L) | 74.1±185.7 | 39.1±43.5 | 0.694 | 0.491 |
单核细胞(×106/L) | 44.6±64.4 | 35.3±39.2 | 0.508 | 0.613 |
蛋白(g/L) | 0.3±0.5 | 0.3±0.2 | 0.136 | 0.892 |
糖(mmol/L) | 3.4±0.6 | 3.6±0.7 | -0.683 | 0.498 |
Table 4 Analysis of cerebrospinal fluid examination results of children with anti-NMDAR encephalitis
指标 | 未复发组(n=40) | 复发组(n=14) | t值 | P值 |
---|---|---|---|---|
白细胞(×106/L) | 74.1±185.7 | 39.1±43.5 | 0.694 | 0.491 |
单核细胞(×106/L) | 44.6±64.4 | 35.3±39.2 | 0.508 | 0.613 |
蛋白(g/L) | 0.3±0.5 | 0.3±0.2 | 0.136 | 0.892 |
糖(mmol/L) | 3.4±0.6 | 3.6±0.7 | -0.683 | 0.498 |
项目 | 未复发组(n=40) | 复发组(n=14) | t值 | P值 |
---|---|---|---|---|
总T淋巴细胞(%) | 66.8±6.0 | 60.1±7.7 | 2.150 | 0.045 |
CD4+T淋巴细胞(%) | 35.6±7.0 | 28.1±4.7 | 2.386 | 0.028 |
CD8+T淋巴细胞(%) | 24.3±3.5 | 24.4±8.3 | -0.034 | 0.973 |
CD4/CD8 | 1.5±0.4 | 1.3±0.5 | 0.857 | 0.402 |
总B淋巴细胞(%) | 21.8±6.1 | 21.4±11.6 | 0.095 | 0.925 |
IgA(g/L) | 1.5±0.8 | 1.3±0.9 | 0.495 | 0.625 |
IgM(g/L) | 1.4±0.5 | 1.2±0.6 | 1.121 | 0.273 |
IgG(g/L) | 11.2±4.4 | 10.2±3.4 | 0.538 | 0.596 |
Table 5 Immune system examination results of children with anti-NMDAR encephalitis
项目 | 未复发组(n=40) | 复发组(n=14) | t值 | P值 |
---|---|---|---|---|
总T淋巴细胞(%) | 66.8±6.0 | 60.1±7.7 | 2.150 | 0.045 |
CD4+T淋巴细胞(%) | 35.6±7.0 | 28.1±4.7 | 2.386 | 0.028 |
CD8+T淋巴细胞(%) | 24.3±3.5 | 24.4±8.3 | -0.034 | 0.973 |
CD4/CD8 | 1.5±0.4 | 1.3±0.5 | 0.857 | 0.402 |
总B淋巴细胞(%) | 21.8±6.1 | 21.4±11.6 | 0.095 | 0.925 |
IgA(g/L) | 1.5±0.8 | 1.3±0.9 | 0.495 | 0.625 |
IgM(g/L) | 1.4±0.5 | 1.2±0.6 | 1.121 | 0.273 |
IgG(g/L) | 11.2±4.4 | 10.2±3.4 | 0.538 | 0.596 |
项目 | 未复发组(n=40) | 复发组(n=14) | χ2(t)值 | P值 |
---|---|---|---|---|
免疫治疗前病程( | 9.4±8.5 | 9.8±7.8 | -0.159a | 0.874 |
免疫球蛋白治疗≥2轮〔n(%)〕 | 3(7.5) | 3(21.4) | 0.871 | 0.351 |
激素冲击治疗≥2轮〔n(%)〕 | 4(10.0) | 1(7.1) | <0.001 | 1.000 |
二线免疫治疗〔n(%)〕 | 3(7.5) | 4(28.6) | 2.427 | 0.119 |
抗癫痫药〔n(%)〕 | 21(52.5) | 10(71.4) | 1.520 | 0.218 |
出院时mRS( | 0.6±0.7 | 1.0±0.8 | -1.707a | 0.094 |
完全缓解〔n(%)〕 | 22(55.0) | 4(28.6) | 2.901 | 0.089 |
Table 6 Treatment and prognosis of children with anti-NMDAR encephalitis
项目 | 未复发组(n=40) | 复发组(n=14) | χ2(t)值 | P值 |
---|---|---|---|---|
免疫治疗前病程( | 9.4±8.5 | 9.8±7.8 | -0.159a | 0.874 |
免疫球蛋白治疗≥2轮〔n(%)〕 | 3(7.5) | 3(21.4) | 0.871 | 0.351 |
激素冲击治疗≥2轮〔n(%)〕 | 4(10.0) | 1(7.1) | <0.001 | 1.000 |
二线免疫治疗〔n(%)〕 | 3(7.5) | 4(28.6) | 2.427 | 0.119 |
抗癫痫药〔n(%)〕 | 21(52.5) | 10(71.4) | 1.520 | 0.218 |
出院时mRS( | 0.6±0.7 | 1.0±0.8 | -1.707a | 0.094 |
完全缓解〔n(%)〕 | 22(55.0) | 4(28.6) | 2.901 | 0.089 |
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