Latest Research on the Neuroprotective
Mechanism of Short-chain Fatty Acids in Stroke and Its Relation with
Post-stroke Cognitive Impairment

doi:10.12114/j.issn.1007-9572.2021.00.569

Abstract

Abstract:

Post-stroke cognitive impairment is one of the common complications of stroke, seriously affecting patients' ability to perform activities of daily living. Recent studies about microbiota-gut-brain axis have found that gut microbiota and their metabolites play an important role in the development of neurological diseases. Short-chain fatty acids, the main metabolites of gut microbiota, are key transmitters of gut-brain communication, which have a neuroprotective effect in stroke, yet the mechanism of action is not fully clear. This paper presents a review of the neuroprotective mechanism of short-chain fatty acids in stroke, and its relation with post-stroke cognitive impairment, providing evidence for studying the pathogenesis and treatment of stroke.

Key words: Stroke, Cognition disorders, Fatty acids, volatile, Short chain fatty acids, Microglia, Neurotrophic factor, Blood-brain barrier, Histone deacetylase, Neuroinflammation

摘要：

脑卒中后认知障碍是脑卒中常见并发症之一，严重影响患者日常生活自理能力。近年来肠道微生物群-肠-脑轴研究发现，肠道微生物群及其代谢产物在神经系统疾病的发生、发展中发挥着重要作用，而肠道微生物群主要代谢产物短链脂肪酸是肠-脑沟通的关键递质，对脑卒中具有保护作用，但其具体作用机制尚不完全清楚。本文主要综述了短链脂肪酸对脑卒中的保护作用机制及其与脑卒中后认知障碍的关系，以期为脑卒中的发病机制和治疗研究等提供参考。

关键词: 卒中, 认知障碍, 脂肪酸类, 挥发性, 短链脂肪酸, 小神经胶质细胞, 神经营养因子, 血脑屏障, 组蛋白去乙酰化酶, 神经炎症

CLC Number:

R743R741R344.7

LIU Huanhuan, LI Ruiqing, SU Kaiqi, YUAN Jie, LI Qi, FENG Xiaodong.

Latest Research on the Neuroprotective Mechanism of Short-chain Fatty Acids in Stroke and Its Relation with Post-stroke Cognitive Impairment [J]. Chinese General Practice, 2022, 25(03): 380-386.

刘环环,李瑞青,苏凯奇等. 短链脂肪酸对脑卒中的保护作用机制及其与脑卒中后认知障碍关系的研究进展[J]. 中国全科医学, 2022, 25(03): 380-386. DOI: 10.12114/j.issn.1007-9572.2021.00.569.

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Latest Research on the Neuroprotective Mechanism of Short-chain Fatty Acids in Stroke and Its Relation with Post-stroke Cognitive Impairment

短链脂肪酸对脑卒中的保护作用机制及其与脑卒中后认知障碍关系的研究进展

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