Ferroptosis Pathway and Process in Cardiovascular Disease

doi:10.12114/j.issn.1007-9572.2021.01.301

Abstract

Abstract: Ferroptosis is a novel mode of cell death that is neither apoptotic nor necrotic and has characteristics that are distinct from other forms of regulated cell death，such as：iron dependency，redox balance dosorder mediated by glutathione and glutathione peroxidase 4，and lipid peroxidation. Recent studies have found that ferroptosis also plays an important role in cardiovascular disease. This paper reviews the research progress of ferroptosis pathway and its role in cardiovascular disease. It has been found that the molecular regulation of ferroptosis has made rapid progress，but the research on ferroptosis and heart disease has just started. To further explore the mechanism of ferroptosis and its role in cardiovascular disease can provide more scientific basis for targeting ferroptosis as the prevention and treatment of heart disease.

Key words: Ferroptosis, Cell death, Glutathione peroxidase 4, Cardiovascular disease

摘要： 铁死亡是一种既非凋亡又非坏死的新型细胞死亡方式，具有不同于其他形式的调节性细胞死亡的特征，例如：铁依赖、谷胱甘肽和谷胱甘肽过氧化物酶4介导的氧化还原平衡紊乱，以及脂质过氧化。近年来研究发现铁死亡也在心血管疾病中发挥重要作用。此文总结了铁死亡通路及其在心血管疾病中的研究进展，发现铁死亡的分子调控方面已取得迅速进展，但铁死亡与心血管疾病之间的研究刚起步。进一步探讨铁死亡的机制及其在心血管疾病中发挥的作用，可为靶向铁死亡作为心血管疾病防治策略提供更多的科学依据。

关键词: 铁死亡, 细胞死亡, 谷胱甘肽过氧化物酶4, 心血管疾病

LYU Mingming,ZHENG Zaiyong,ZHANG Yulong, et al. Ferroptosis Pathway and Process in Cardiovascular Disease　[J]. Chinese General Practice, 2021, 24(29): 3769-3773. DOI: 10.12114/j.issn.1007-9572.2021.01.301.
吕明明,郑在勇,张玉龙等. 铁死亡通路与心血管疾病的研究进展[J]. 中国全科医学, 2021, 24(29): 3769-3773. DOI: 10.12114/j.issn.1007-9572.2021.01.301.

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