Modulation of Iron Death by Poric Acid through Nrf2/SLC7A11/GPX4 Signal Pathway in the Improvement of Cognitive Impairment of Alzheimer's Disease Rats
1Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China 2Nanyang Central Hospital, Nanyang 473000, China 3Nanyang Institute of Technology, Zhang Zhongjing Traditional Chinese Medicine College/Zhang Zhongjing Key Laboratory of Prescriptions and Immunomodulation, Nanyang 473000, China
FAN Yun,DOU Runpeng,HU Jiulue, et al. Modulation of Iron Death by Poric Acid through Nrf2/SLC7A11/GPX4 Signal Pathway in the Improvement of Cognitive Impairment of Alzheimer's Disease Rats[J]. Chinese General Practice, 2024, 27(02): 177-183. DOI: 10.12114/j.issn.1007-9572.2023.0326.
樊赟,窦润鹏,胡久略等. 茯苓酸通过Nrf2/SLC7A11/GPX4信号通路调控铁死亡改善阿尔茨海默病大鼠认知障碍的研究[J]. 中国全科医学, 2024, 27(02): 177-183. DOI: 10.12114/j.issn.1007-9572.2023.0326.
SIZ Z,ZOUC J,MEIX,et al. Targeting neuroinflammation in Alzheimer's disease:from mechanisms to clinical applications[J]. Neural Regen Res,2023,18(4):708-715. DOI:10.4103/1673-5374.353484.
[2]
BAOW D,PANGP,ZHOUX T,et al. Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease[J]. Cell Death Differ,2021,28(5):1548-1562. DOI:10.1038/s41418-020-00685-9.
[3]
BAOW D,ZHOUX T,ZHOUL T,et al. Targeting miR-124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model[J]. Aging Cell,2020,19(11):e13235. DOI:10.1111/acel.13235.
[4]
GEM H,TIANH,MAOL,et al. Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway[J]. CNS Neurosci Ther,2021,27(9):1023-1040. DOI:10.1111/cns.13657.
YANGT,TIANS J,WANGY H,et al. Antitumor activity of pachymic acid in cervical cancer through inducing endoplasmic reticulum stress,mitochondrial dysfunction,and activating the AMPK pathway[J]. Environ Toxicol,2022,37(9):2121-2132. DOI:10.1002/tox.23555.
[7]
ZHAIY,LIUB G,WUL,et al. Pachymic acid prevents neuronal cell damage induced by hypoxia/reoxygenation via miR-155/NRF2/HO-1 axis[J]. Acta Neurobiol Exp,2022,82(2):197-206. DOI:10.55782/ane-2022-018.
PANGY Q,ZHUS Z,PEIH T. Pachymic acid protects against cerebral ischemia/reperfusion injury by the PI3K/Akt signaling pathway[J]. Metab Brain Dis,2020,35(4):673-680. DOI:10.1007/s11011-020-00540-3.
WEIC Y,WANGH Z,SUNX,et al. Pharmacological profiles and therapeutic applications of pachymic acid(Review)[J]. Exp Ther Med,2022,24(3):547. DOI:10.3892/etm.2022.11484.
[15]
ALIMI,CAULFIELDJ T,CHENY X,et al. Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke[J]. Cell,2019,177(5):1262-1279.e25. DOI:10.1016/j.cell.2019.03.032.
FUC,WUY F,LIUS J,et al. Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia[J]. J Ethnopharmacol,2022,289:115021. DOI:10.1016/j.jep.2022.115021.
[18]
JIANGG P,LIAOY J,HUANGL L,et al. Effects and molecular mechanism of pachymic acid onferroptosis in renal ischemia reperfusion injury[J]. Mol Med Rep,2021,23(1):63. DOI:10.3892/mmr.2020.11704.
[19]
LIM Y,DAIX H,YUX P,et al. Scalp acupuncture protects against neuronal ferroptosis by activating the p62-Keap1-Nrf2 pathway in rat models of intracranial haemorrhage[J]. J Mol Neurosci,2022,72(1):82-96. DOI:10.1007/s12031-021-01890-y.