Application and Research Progress of Ozone in Clinical Pain Medicine

doi:10.12114/j.issn.1007-9572.2019.00.720

Abstract

Abstract: Ozone is an allotrope of oxygen，which has been used in clinic because of its strong oxidizing properties.With the deepening of research on the mechanism of action of ozone，ozone therapy technology has been widely used in clinical practice，especially in the field of clinical pain medicine.This paper reviews the application and research of medical ozone in pain medicine to further explore the mechanism of medical ozone in the treatment of pain and formulate systematic medical ozone treatment criteria and evaluation indicators in order to improve the efficacy as well as reduce technical risks，which provides a reference for future clinical research of medical ozone.

Key words: Pain, Ozone, Application, Research, Review

摘要： 臭氧是氧气的同素异形体，因具极强氧化性而被应用于临床。随着臭氧作用机制研究不断深入，臭氧治疗技术在临床上得到广泛应用，特别在临床疼痛医学治疗领域中发展迅速。本文针对其在疼痛医学中的应用及研究做一综述，进一步探讨医用臭氧治疗疼痛的作用机制，制定系统的医用臭氧治疗规范和疗效评价指标，提高疗效，减少技术风险，为今后临床研究方向提供参考。

关键词: 疼痛, 臭氧, 应用, 研究, 综述

WEI Yingcheng*,LIANG Xiaohang,WU Xiaomei, et al. Application and Research Progress of Ozone in Clinical Pain Medicine[J]. Chinese General Practice, 2020, 23(23): 2969-2974. DOI: 10.12114/j.issn.1007-9572.2019.00.720.
韦英成*,梁晓行,吴肖梅等. 臭氧在临床疼痛医学中的应用及研究进展[J]. 中国全科医学, 2020, 23(23): 2969-2974. DOI: 10.12114/j.issn.1007-9572.2019.00.720.

References

［1］BOCCI V.Ozone—a new medical drug［M］．Netherlands：Springer，2005：20-28，75-83，198-239．
［2］BOCCI V，ZANARDI I，TRAVAGLI V.Ozone：a new therapeutic agent in vascular diseases［J］．Am J Cardiovasc Drugs，2011，11（2）：73-82．DOI：10.2165/11539890-000000000-00000.
［3］BOCCI V A.Scientific and medical aspects of ozone therapy.State of the art［J］．Arch Med Res，2006，37（4）：425-435．DOI：10.1016/j.arcmed.2005.08.006.
［4］段轶轩，张照庆，骆小娟，等．内热针结合臭氧穴位注射治疗中风后肩痛的近期及远期疗效分析［J］．针刺研究，2019，44（1）：51-56．DOI：10.13702/j.1000-0607.170453.
DUAN Y X，ZHANG Z Q，LUO X J，et al．Short-term and long-term therapeutic effects of internal heat-type acupuncture needle therapy combined with acupoint injection of O3 for post-stroke shoulder pain［J］．Acupuncture Research，2019，44（1）：51-56．DOI：10.13702/j.1000-0607.170453.
［5］赵美一，王焕玲，刘金锋.臭氧治疗安全性和有效性的研究进展［J］．中国疼痛医学杂志，2019，25（5）：383-386．DOI：10.3969/j.issn.1006-9852.2019.05.012.https：//kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2019&filename=ZTYZ201905015&v=MDQ2MjVMRzRIOWpNcW85RVlZUjhlWDFMdXhZUzdEaDFUM3FUcldNMUZyQ1VSTE9mYnVkdkZ5M21Xci9JUHpuU2Q=.
［6］AZUMA K，MORI T，KAWAMOTO K，et al．Anti-inflammatory effects of ozonated water in an experimental mouse model［J］．Biomed Report，2014，2（5）：671-674．DOI：10.3892/br.2014.290.
［7］江静，黎春晖，聂敏海.臭氧水对口臭相关细菌的体外抑制效果研究［J］．实用口腔医学杂志，2019，35（1）：20-23．DOI：10.3969/j.issn.1001-3733.2019.01.004.
JIANG J，LI C H，NIE M H.The inhibitory effect of ozone water on bad breath pathogens in vitro［J］．Journal of Practical Stomatology，2019，35（1）：20-23．DOI：10.3969/j.issn.1001-3733.2019.01.004.
［8］ELVIS A M，EKTA J S.Ozone therapy：a clinical review［J］．J Nat Sci Biol Med，2011，2（1）：66-70．DOI：10.4103/0976-9668.82319.
［9］LO GIUDICE G，VALDI F，GISMONDI M，et al．Acute bilateral vitreo-retinal hemorrhages following oxygen-ozone therapy for lumbar disk herniation［J］．Am J Ophthalmol，2004，138（1）：175-177．DOI：10.1016/j.ajo.2004.02.059.
［10］TRAVAGLI V，ZANARDI L，SILVIETTI A，et al．A physicochemical investi gation on the effects of ozone on blood［J］．Int J Biol Macromol，2007，41（5）：504-511．DOI：10.1016/j.ijbiomac.2007.06.010.
［11］田锦林，张金山，肖越勇，等．高浓度臭氧注入猪蛛网膜下腔后对脑脊液和脊髓的影响［J］．中国介入影像与治疗学，2007，4（4）：310-313．DOI：10.3969/j.issn.1672-8475.2007.04.018.
TIAN J L，ZHANG J S，XIAO Y Y，et al．Effect of high concentration ozone to cerebrospinal fluid and spinal cord after injection into subarachnoid space：an experimental study in pigs［J］．Chinese Journal of Interventional Imaging and Therapy，2007，4（4）：310-313．DOI：10.3969/j.issn.1672-8475.2007.04.018.
［12］ZHOU N B，FU Z J，SUN T.Effects of different concentrations of oxygen-ozone on rats' astrocytes in vitro［J］．Neurosci Lett，2008，441（2）：178-182．DOI：10.1016/j.neulet.2008.06.036.
［13］李泓锡，姚鹏.神经妥乐平联合医用臭氧治疗周围神经病变的效果观察［J］．医学综述，2017，23（15）：3102-3106．DOI：10.3969/j.issn.1006-2084.2017.15.038.
LI H X，YAO P.Effect of neurotropin combined with medical ozone in treating peripheral neuropathy［J］．Medical Recapitulate，2017，23（15）：3102-3106．DOI：10.3969/j.issn.1006-2084.2017.15.038.
［14］孙运中，郭晓丽，王晓川，等．脉冲射频联合臭氧自体血回输治疗带状疱疹［J］．中国疼痛医学杂志，2018，24（12）：951-955．DOI：10.3969/j.issn.1006-9852.2018.12.014.http：//d.old.wanfangdata.com.cn/Periodical/zgttyxzz201812016.
［15］赵旭，傅志俭.医用臭氧临床应用和安全性研究进展［J］．中国疼痛医学杂志，2018，24（7）：489-492．DOI：10.3969/j.issn.1006-9852.2018.07.002.http：//d.old.wanfangdata.com.cn/Periodical/zgttyxzz201807003.
［16］TREEDE R D，RIEF W，BARKE A，et al．A classification of chronic pain for ICD-11［J］．Pain，2015，156（6）：1003-1007．DOI：10.1097/j.pain.0000000000000160.
［17］韩睿，廖琴，阳晓燕，等．一种新的疼痛分类方法和治疗思路［J］．中国疼痛医学杂志，2017，23（5）：328-330．DOI：10.3969/j.issn.1006-9852.2017.05.003.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgttyxzz201705004.
［18］李芸，傅志俭.臭氧治疗炎性痛的应用研究［J］．中国疼痛医学杂志，2016，22（3）：168-171．DOI：10.3969/j.issn.1006-9852.2016.03.002.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgttyxzz201603002.
［19］李润辉.臭氧治疗的临床应用及研究进展［J］．沈阳医学院学报，2014，16（3）：134-137．DOI：10.3969/j.issn.1008-2344.2014.03.002.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=syyxyxb201403002.
［20］SNIGORENKO A S，SHEVCHENKO V P.Ozone therapy and enteral nutrition in the combined treatment of the enteral failure syndrome in peritonitis［J］．Voen Med Zh，2000，321（3）：20-23.
［21］覃黎葵，邓天好，龚正，等．医用三氧结肠灌注合美沙拉嗪治疗溃疡性结肠炎40例［J］．湖南中医杂志，2012，28（3）：52-54．DOI：10.16808/j.cnki.issn1003-7705.2012.03.025.https：//kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFD2012&filename=HNZO201203028&v=MTc0NzQ5SGJJUjhlWDFMdXhZUzdEaDFUM3FUcldNMUZyQ1VSTE9mYnVkdkZ5M2dWTHZBTFNQUlliRzRIOVBNckk=.
［22］KUDRIAVTSEV E P，MIROSHIN S I，SEMENOV S V，et al．
Ozone therapy of diffuse peritonitis in the early postoperative period［J］．Khirurgiia（Mosk），1997（3）：36-41.
［23］NAGAYOSHI M，FUKUIZUMI T，KITAMURA C，et al．Efficacy of ozone on survival and permeability of oral microorganisms［J］．Oral Microbiol Immunol，2004，19（4）：240-246．DOI：10.1111/j.1399-302X.2004.00146.x.
［24］宁洪叶，彭福江，周福元.医用臭氧治疗慢性乙型病毒性肝炎［J］．南方医科大学学报，2009，29（6）：1277-1278．DOI：10.3321/j.issn:1673-4254.2009.06.059.http：//med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_dyjydxxb200906059.
［25］王兵，董桂芝，鞠衍馨，等．臭氧与玻璃酸钠治疗膝骨性关节炎疗效的比较［J］．中国骨与关节损伤杂志，2014，29（8）：782-784．DOI：10.7531/j.issn.1672-9935.2014.08.015.
WANG B，DONG G Z，JU Y X，et al．Curative effect of ozone and sodium hyaluronate for knee osteoarthritis［J］．Chinese Journal of Bone and Joint Injury，2014，29（8）：782-784．DOI：10.7531/j.issn.1672-9935.2014.08.015.
［26］张威.医用臭氧局部注射治疗桡骨茎突狭窄性腱鞘炎的回顾性研究［D］．新乡：新乡医学院，2016.
ZHANG W.Retrospective study of medical ozone local injection in treatment of radial styloid narrow tenosynovitis［D］．Xinxiang：Xinxiang Medical University，2016.
［27］王冠羽，张金山，张宏，等．关节腔臭氧冲洗联合玻璃酸钠治疗膝关节骨性关节炎疗效分析［J］．中国疼痛医学杂志，2013，19（7）：432-434．DOI：10.3969/j.issn.1006-9852.2013.07.012.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgttyxzz201307012.
［28］陈文锦，华臻，周智毅，等．关节腔内注射氧-臭氧治疗膝骨关节炎的临床疗效［J］．江苏医药，2019，45（1）：31-34．DOI：10.19460/j.cnki.0253-3685.2019.01.009.
CHEN W J，HUA Z，ZHOU Z Y，et al．Clinical efficacy of intra-articular injection of oxygen-ozone in treatment of knee osteoarthritis［J］．Jiangsu Medical Journal，2019，45（1）：31-34．DOI：10.19460/j.cnki.0253-3685.2019.01.009.
［29］仝冬利，赵修照.穴位注射臭氧水治疗颈型颈椎病疗效观察［J］．中医临床研究，2016，8（23）：99-100．DOI：10.3969/j.issn.1674-7860.2016.23.048.
TONG D L，ZHAO X Z.Treating cervical spondylopathy by ozone water acupoint injection［J］．Clinical Journal of Chinese Medicine，2016，8（23）：99-100．DOI：10.3969/j.issn.1674-7860.2016.23.048.
［30］周友龙，党琦，郭明菲，等．医用臭氧水穴位注射治疗椎动脉型颈椎病60例［J］．光明中医，2016，31（21）：3162-3163．DOI：10.3969/j.issn.1003-8914.2016.21.045.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=gmzy201621046.
［31］谈天明，王秀丽.臭氧注射、局封结合关节松动术治疗肩周炎的临床观察［J］．颈腰痛杂志，2013，34（4）：339-340，342．DOI：10.3969/j.issn.1005-7234.2013.04.019.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=jytzz201304019.
［32］俞志坚，杨波，朱正兵，等．医用臭氧局部注射治疗梨状肌综合征［J］．中国医师杂志，2004，6（8）：1103-1104．DOI：10.3760/cma.j.issn.1008-1372.2004.08.052.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgyszz200408052.
［33］周友龙，辛瑶瑶，朱紫燕，等．臭氧水穴位注射治疗强直性脊柱炎60例［J］．中医研究，2015，28（10）：32-34．DOI：10.3969/j.issn.1001-6910.2015.10.15.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zyyj201510015.
［34］路训平，马延彬，王丰爱，等．臭氧联合关节冲洗治疗痛风性关节炎186例初步疗效观察［J］．中国矫形外科杂志，2013，21（20）：2119．DOI：10.3977/j.issn.1005-8478.2013.20.25.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgjxwkzz201320025.
［35］魏薇.臭氧水注射治疗强直性脊柱炎临床观察［J］．生物技术世界，2015，12（4）：77.http：//www.cnki.com.cn/Article/CJFDTotal-SWJJ201504066.htm.
［36］左刚，岳岩岩.独活寄生汤合臭氧水注射治疗强直性脊柱炎40例临床疗效观察［J］．中国民间疗法，2016，24（2）：61-62．DOI：10.19621/j.cnki.11-3555/r.2016.02.051.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgmjlf201602049.
［37］谢小英，茹晋丽，张露月.系统性红斑狼疮患者三氧基本自体血疗法的护理［J］．中国药物与临床，2015，15（9）：1234-1236．DOI：10.11655/zgywylc2015.09.005.
XIE X Y，RU J L，ZHANG L Y.Nursing experience of ozone major autohaemotherapy on systemic lupus erythematosus［J］．Chinese Remedies & Clinics，2015，15（9）：1234-1236．DOI：10.11655/zgywylc2015.09.005.
［38］NICKEL F T，SEIFERT F，LANZ S，et al．Mechanisms of neuropathic pain［J］．Eur Neuropsychopharmacol，2012，22（2）：81-91．DOI：10.1016/j.euroneuro.2011.05.005.
［39］神经病理性疼痛诊疗专家组.神经病理性疼痛诊疗专家共识［J］．中国疼痛医学杂志，2013，19（12）：705-710．DOI：10.3969/j.issn.1006-9852.2013.12.001.http：//med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_zgttyxzz201312001.
［40］周广明.医用臭氧在疼痛治疗的应用［J］．医学信息，2018，31（11）：67-69.
ZHOU G M.Application of medical ozone in pain therapy［J］．Medical Information，2018，31（11）：67-69.
［41］德布新，冷辉，吴景山.腰椎间盘突出症的微创治疗及现状［J］．世界最新医学信息文摘，2018，18（98）：141-142．DOI：10.19613/j.cnki.1671-3141.2018.98.061.http：//www.cnki.com.cn/Article/CJFDTotal-WMIA201898061.htm.
［42］ANDREULA C F，SIMONETTI L，DE SANTIS F，et al．Minimally invasive oxygen-ozone therapy for lumbar disk herniation［J］．AJNR Am J Neuroradiol，2003，24（5）：996-1000.
［43］DURNOGO E A，KINIAPINA I D.The effect of ozone therapy on the dynamic spectrum of the peripheral blood proteins in patients with phlegmons of the face and neck［J］．Stomatologiia（Mosk），1999，78（5）：31-34.
［44］BIEDUNKIEWICZ B，TYLICKI L，NIEWEGLOWSKI T，et al．
Clinical efficacy of ozonated autohemotherapy in hemodialyzed patients with intermittent claudication：an oxygen-controlled study［J］．Int J Artif Organs，2004，27（1）：29-34.
［45］TYLICKI L，BIEDUNKIEWICZ B，NIEWEGLOWSKI T，et al．Ozonated autohemotherapy in patients on maintenance hemodialysis：influence on lipid profile and endothelium ［J］．Artif Organs，2004，28（2）：234-237．DOI：10.1111/j.1525-1594.2003.47211.x.
［46］范亚云，郭书萍.医用臭氧在皮肤科疾病治疗中的应用进展［J］．中国现代医药杂志，2018，20（2）：102-105．DOI：10.3969/j.issn.1672-9463.2018.02.032.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zghtyyzz201802033.
［47］叶雷，陆丽娟，顾丽莉，等．臭氧大自血疗法治疗带状疱疹的临床观察［J］．中华临床医师杂志（电子版），2013，7（19）：8981-8983．DOI：10.3877/cma.j.issn.1674-0785.2013.19.108.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zhlcyszz201319107.
［48］王迪，王栋、刘克飞，等．射频热凝联合臭氧消融术治疗椎间盘源性腰痛37例［J］．风湿病与关节炎，2014，3（9）：34-36．DOI：10.3969/j.issn.2095-4174.2014.09.009.http：//www.wanfangdata.com.cn/details/detail.do?_type=perio&id=fsbygjy201409011.
［49］BONETTI M，FONTANA A，COTTICELLI B，et al．Intraforaminal O2-O3 versus periradicular steroidal infiltrations in lower back pain：randomized controlled study［J］．AJNR Am J Neuroradiol，2005，26（5）：996-1000.
［50］PORTENOY R K.Treatment of cancer pain［J］．Lancet，2011，377（9784）：2236-2247．DOI：10.1016/S0140-6736（11）60236-5.
［51］METE F，TARHAN H，CELIK O，et al．Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats［J］．Asian J Androl，2017，19（1）：43-46．DOI：10.4103/1008-682X.171570.
［52］SAYAR I，BICER S，GURSUL C，et al．Protective effects of ellagic acid and ozone on rat ovaries with an ischemia/reperfusion injury［J］．J Obstet Gynaecol Res，2016，42（1）：52-58．DOI：10.1111/jog.12858.
［53］OZKAN H，EKINCI S，UYSAL B，et al．Evaluation and comparison of the effect of hypothermia and ozone on ischemia-reperfusion injury of skeletal muscle in rats［J］．J Surg Res，2015，196（2）：313-319．DOI：10.1016/j.jss.2015.01.053.
［54］卢振和.疼痛新定义有助于诊疗感觉神经系统损伤［J］．中国疼痛医学杂志，2016，22（4）：248-249．DOI：10.3969/j.issn.1006-9852.2016.04.03.http：//med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_zgttyxzz201604004.
［55］COPPOLA L，LUONGO C，PASTORE A，et al．Ozonized autohaemotransfusion could be a potential rapid-acting antidepressant medication in elderly patients［J］．Int J Geriatr Psychiatry，2010，25（2）：208-213．DOI：10.1002/gps.2322.
［56］KOTOV S A.Ozone therapy of migraine［J］．Zh Nevrol Psikhiatr Im S S Korsakova，2000，100（11）：35-37.
［57］闫清华，张广建，李仁淑.臭氧在疼痛性疾病治疗中的应用进展［J］．颈腰痛杂志，2015，36（2）：153-155．DOI：10.3969/j.issn.1005-7234.2015.02.16.http：//med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_jytzz201502016.

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