Abstract: Background　The Patient Health Questionnaire-2（PHQ-2） is a short and effective tool widely used for screening depression mainly in people aged 12 and over（evidence level B）abroad，and in specific populations in China，but less for the investigation of general population.Objective　To investigate the prevalence and influencing factors of depression among adults undergoing physical examination in a general hospital.Methods　Cluster sampling was applied to select adults（≥18 years old） undergoing physical examination in April 2016 from Physical Examination Center，The University of Hong Kong-Shenzhen Hospital.General Information of Physical Examinees and Chinese version of PHQ-2（PHQ-2-C）were used to collect information，including gender，age，education level，marital status，self-assessed health status，exercise habits，smoking，drinking，overall sleeping quality，and information specially designed for women，such as gravidity，parity，contraceptive method，gynecological disease，and so on.Multivariate Logistic regression analysis was used to explore the related factors of depression.Results　Altogether，6 560 cases participated in the survey，and 6 518 of them（99.36%） returned responsive questionnaires.The overall prevalence of depression was 3.84%（250/6 518）.The prevalence of depression showed significant variations according to gender，age，marital status，self-assessed health status，exercise habit，smoking habit，and overall sleeping quality（P<0.05）.Multivariate Logistic regression analysis indicated that gender，age，marital status，self-assessed health status，exercise habit，smoking habit and overall sleeping quality were influencing factors of depression（P<0.05）.The prevalence of depression in women demonstrated significant variations according to parity，contraceptive method and gynecological disease prevalence（P<0.05）.Conclusion　In this adult population，the overall prevalence of depression was 3.84%.Female was associated with higher depression prevalence.Younger age，separation/divorce/widowhood，poor self-assessed health，no/little exercise，frequent smoking and poor overall sleeping quality are the risk factors for depression.And parity，contraceptive method and gynecological disease may be additional factors affecting depression prevalence in female population.

Key words: Depressive disorder, Healthy physical examination population in general hospital, PHQ-2 questionnaire for depression, Related factors, Surveys

摘要： 背景　两条目患者健康问卷抑郁量表（PHQ-2）作为一个简短有效的抑郁筛查工具在国外及国内广泛应用，国外主要应用在12岁以上患者的抑郁筛查（证据B级），国内主要应用在特定人群抑郁的流行病学调查，而关于一般人群的调查较少。目的　了解体检人群抑郁状况，分析抑郁状态的影响因素。方法　采用整群抽样的方法，抽取2016年4月在香港大学深圳医院体检中心的体检者（≥18岁）为调查对象，以体检者的一般信息及PHQ-2中文版（PHQ-2-C）为调查工具，收集体检者的性别、年龄、受教育程度、婚姻状态、健康状态自评、运动习惯、吸烟习惯、饮酒习惯、总体睡眠质量及女性体检者妊娠次数、生育情况、避孕方式、妇科疾病等情况。采用多因素Logistic回归分析探讨抑郁发生的影响因素。结果　共回收问卷6 560份，其中有效问卷6 518份，问卷有效回收率为99.36%，抑郁状况阳性率为3.84%（250/6 518）。不同性别、年龄、婚姻状况、健康状态自评、运动习惯、吸烟习惯、总体睡眠质量的体检者抑郁情况不同，差异均有统计学意义（P<0.05）。多因素Logistic回归分析结果显示，性别、年龄、婚姻状况、健康状态自评、运动习惯、吸烟习惯、总体睡眠质量是抑郁发生的影响因素（P<0.05）。不同生育情况、避孕方式、妇科疾病女性体检者抑郁情况比较，差异均有统计学意义（P<0.05）。结论　综合医院体检人群抑郁状况阳性率为3.84%，且女性高于男性。低龄、分居/离婚/丧偶、健康状态自评差、没有/甚少运动习惯、经常吸烟、总体睡眠质量不好是体检人群有抑郁状况的危险因素。而生育情况、避孕方式、妇科疾病会影响女性的抑郁情况。

关键词: 抑郁症, 综合医院健康体检人群, PHQ-2抑郁筛查量表, 相关因素, 调查