Abstract: Background　Cognitive impairment is one of the important causes of incapacitation for work in depressed patients.Some domestic studies have suggested that rumination is related to cognitive function in normal population，but few studies have evaluated the relationship between rumination and executive function，a core component of cognitive function，in depressed patients.Objective　To investigate the relationship between rumination and severity of depression，executive function in unmedicated depressed patients.Methods　116 unmedicated depressed patients from Psychiatric Department，the Second Xiangya Hospital of Central South University were enrolled by convenient sampling method from September 2017 to April 2019.The Chinese version of the Ruminative Response Scale（RRS-C），17-item Hamilton Depression Rating Scale（HDRS）and Wisconsin Card Sorting Test（WCST）were used to measure patients' rumination，executive function and depression，respectively.Pearson correlation analysis was used to explore the correlation of rumination with depression severity and executive function，respectively.Results　The RRS-C score of the patients ranged from 37 to 85 points〔average score：（64.1±12.5）points〕.And the HDRS score ranged from 18 to 36 points〔average score：（23.3±5.1）points）〕.The HDRS score was positively correlated with RRS-C score（r=0.480，P<0.001）， symptom rumination score（r=0.688，P<0.001）， responses administered（r=0.278，P=0.004），total number of errors （r=0.329，P=0.001）and the number of perseverative errors（r=0.311，P=0.001）during the WCST，but was negatively correlated with the categories completed（r=-0.299，P=0.002）.Conclusion　The rumination level of unmedicated depressed patients is higher，which is positively correlated with the severity of depression but negatively correlated with the executive function.

Key words: Depression, Rumination, Executive function, Cognitive function impairment, Correlation analysis

摘要： 背景　认知损害是导致抑郁症患者工作残疾的重要原因之一，而执行功能是认知功能的重要组成部分，国内部分研究提出反刍思维与正常人群的认知功能有关，但反刍思维与抑郁症患者执行功能之间的关系研究较少。目的　探讨未服药抑郁症患者反刍思维与抑郁严重程度及执行功能之间的关系。方法　采用便利抽样法选取2017年9月—2019年4月在中南大学湘雅二医院精神科就诊的未服用抗抑郁药物的抑郁症患者116例为研究对象，采用中文版反刍思维量表（RRS）、威斯康星卡片分类测验（WCST）软件、汉密尔顿17项抑郁量表分别测量患者的反刍思维、执行功能、抑郁得分，采用Pearson相关分析探讨反刍思维与抑郁严重程度、执行功能的相关性。结果　未服药抑郁症患者反刍思维总分37~85分，平均（64.1±12.5）分；抑郁总分18~36分，平均（23.3±5.1）分。未服药抑郁症患者抑郁得分与反刍思维总分（r=0.480，P<0.001）、反省思考维度得分（r=0.688，P<0.001）、WCST总应答数（r=0.278，P=0.004）、错误应答数（r=0.329，P=0.001）、持续错误数（r=0.311，P=0.001）呈正相关，与完成分类数（r=-0.299，P=0.002）呈负相关。结论　未服药抑郁症患者反刍思维得分较高，并与患者的抑郁严重程度呈正相关，与执行功能呈负相关。

关键词: 抑郁, 反刍思维, 执行功能, 认知损害, 相关性分析