Research Progress on Clinical Application of Humidified High Flow Oxygen Therapy

doi:10.12114/j.issn.1007-9572.2018.00.442

Abstract

Abstract: Humidified high flow nasal cannula（HFNC） is a new oxygen supply device，which can deliver up to 100% humidified and heated oxygen with maximum flow rate of 60 L/min.Compared with standard nasal cannula，HFNC has many advantages.Growing evidence has shown that HFNC is an effective method for the treatment of early respiratory failure in adults associated with different underlying diseases.However，studies have also suggested that improper use of HFNC may delay tracheal intubation and increase mortality，and there also have been reports of severe air leakage events caused by HFNC treatment.Despite the lack of a set of strict and clear guidelines to guide its use，HFNC has become a routine practice applied in different diseases and clinical environments.In this paper，the physiological effect，mechanism of HFNC and its application in a series of clinical environments are reviewed，which provides the basis and reference for the clinical application of HFNC.

Key words: Respiratory insufficiency, Oxygen inhalation therapy, Humidified high flow oxygen therapy, Review

摘要： 高流量湿化氧疗（HFNC）是一种新型的供氧装置，能够以最大流量60 L/min输送100％的加湿、加热氧气，与传统的氧气输送装置相比其存在诸多优势。越来越多的证据表明HFNC是成人早期呼吸衰竭的有效治疗方法。但也有研究指出，不适当使用HFNC可能会延迟气管插管并增加病死率，还有报道HFNC造成严重漏气事件，尽管缺乏一套指导HFNC使用的指南，但将其应用于不同疾病及临床环境已成为惯例。本文从HFNC的生理效应及其在临床中的一系列应用等方面进行综述，为HFNC的临床应用提供依据和参考。

关键词: 呼吸功能不全, 氧吸入疗法, 高流量湿化氧疗, 综述

WU Yuejiao,YANG Shumei,CHEN Ruilin. Research Progress on Clinical Application of Humidified High Flow Oxygen Therapy　[J]. Chinese General Practice, 2019, 22(18): 2253-2257. DOI: 10.12114/j.issn.1007-9572.2018.00.442.
吴月姣,杨淑梅,陈瑞琳. 高流量湿化氧疗的临床应用研究进展[J]. 中国全科医学, 2019, 22(18): 2253-2257. DOI: 10.12114/j.issn.1007-9572.2018.00.442.

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