Abstract: Background　Cancer is a health threat to humans，which has become a worldwide concern.However，studies about cancer-related deaths in working-age population are still rare.Objective　To explore the epidemiological characteristics and trend of cancer-related deaths in working-age population from 2002 to 2015 in Pudong New Area of Shanghai，so as to provide a reference for the development of corresponding intervention measures.Methods　From January 2002 to February 2016，we collected the data regarding cancer-related deaths among working-age population in Shanghai's Pudong New Area during January 1，2002 to December 31，2015 from Pudong New Area Cause-of-death Surveillance Database.Demographic data were collected from Pudong Branch，Shanghai Public Security Bureau.Cancer-related deaths（number of deaths，crude mortality）during 2002—2015 were analyzed by sex，and age group.And the trend of annual crude cancer mortality during the period was analyzed by sex，age group and cause-of-death category.Results　The number of cancer-related deaths among working-age population in Pudong New Area during 2002 to 2015 was 19 021，and the crude mortality was 74.15 per 100 000 persons.The crude cancer mortality in males was higher than that in females（P<0.005）．The crude cancer mortality increased with age（P<0.005）．The crude cancer mortality during the period showed a trend of fluctuation（APC=-0.20，P=0.420），and the changes in annual crude cancer mortality trend were not significant in both males and females（APCmale=-0.01%，P=0.983；APCfemale=-0.48%，P=0.208）．The crude cancer mortality declined significantly in 30-39，40-49，and 50-59 age groups over the year（APC30-39=-2.96%，P<0.001；APC40-49=-2.90%，P=0.002；APC50-59=-1.59%，P=0.033）．Among the leading causes of cancer-related deaths，the crude lung cancer mortality，crude colorectal cancer mortality，and crude pancreatic cancer mortality showed a significant upward trend year by year（APClung cancer=2.04%，P<0.001；APCcolorectal cancer=1.99%，P=0.019；APCpancreatic cancer=2.35%，P=0.038），and the crude liver cancer mortality and crude gastric cancer mortality declined significantly year by year（APCliver cancer=-3.78%，P<0.001；APCgastric cancer=-2.12%，P=0.004）．Conclusion　The annual crude cancer mortality of working-age population in Pudong New Area showed a trend of fluctuation between 2002 and 2015.In particular，the crude lung cancer mortality，crude colorectal cancer mortality，and crude pancreatic cancer mortality increased over the year.So more attention should be paid to prevent against the deaths caused by lung cancer，colorectal cancer and pancreatic cancer，and corresponding interventions should be taken.

Key words: Neoplasms, Mortality, Population of working ages, Trend analysis

摘要： 背景　恶性肿瘤对人群健康的危害已得到全世界的广泛关注，但目前针对劳动适龄人群恶性肿瘤死亡情况的研究依然较少。目的　了解2002—2015年上海市浦东新区劳动适龄人口恶性肿瘤死亡情况及其趋势，为制定相关干预措施提供依据。方法　2002年1月—2016年2月收集上海市浦东新区居民死因监测数据库中2002-01-01至2015-12-31死亡的劳动适龄人口恶性肿瘤死亡资料。人口学资料来源于上海市浦东新区公安局。分析2002—2015年上海市浦东新区不同性别、年龄段劳动适龄人口恶性肿瘤死亡情况（死亡人数、粗死亡率）及不同性别、年龄段、死因分类劳动适龄人口恶性肿瘤粗死亡率年变化趋势。结果　2002—2015年上海市浦东新区劳动适龄人口恶性肿瘤死亡19 021例，粗死亡率为74.15/10万。2002—2015年上海市浦东新区男性劳动适龄人口恶性肿瘤粗死亡率大于女性（P<0.005）。2002—2015年上海市浦东新区劳动适龄人口恶性肿瘤粗死亡率随年龄的增大而上升（P<0.005）。2002—2015年上海市浦东新区劳动适龄人口恶性肿瘤粗死亡率呈现波动状态〔年均变化百分比（APC）=-0.20%，P=0.420〕。2002—2015年上海市浦东新区男、女性劳动适龄人口恶性肿瘤粗死亡率年变化趋势不显著（APC男性=-0.01%，P=0.983；APC女性=-0.48%，P=0.208）。2002—2015年上海市浦东新区30~39、40~49、50~59岁劳动适龄人口恶性肿瘤粗死亡率均呈逐年下降趋势（APC30~39岁=-2.96%，P<0.001；APC40~49岁=-2.90%，P=0.002；APC50~59岁=-1.59%，P=0.033）。2002—2015年上海市浦东新区劳动适龄人口主要恶性肿瘤死因分类中，肺癌、结直肠癌、胰腺癌粗死亡率呈逐年上升趋势（APC肺癌=2.04%，P<0.001；APC结直肠癌=1.99%，P=0.019；APC胰腺癌=2.35%，P=0.038），肝癌、胃癌粗死亡率呈逐年下降趋势（APC肝癌=-3.78%，P<0.001；APC胃癌=-2.12%，P=0.004）。结论　2002—2015年上海市浦东新区劳动适龄人口恶性肿瘤粗死亡率现波动状态，其中肺癌、结直肠癌、胰腺癌粗死亡率逐年上升，值得关注，需采取有针对性的干预措施。

关键词: 肿瘤, 死亡率, 劳动适龄人口, 趋势分析