Abstract: Objective　To explore the clinical effect of endoscopic hemostasis combined with intravenous administration of different doses of esomeprazole sodium on acute peptic ulcer bleeding（APUB）.Methods　We enrolled 160 inpatients with APUB from Department of Gastroenterology，General Hospital of Chinese People's Armed Police Force from January 2016 to January 2018 and equally divided them into standard-dose group（study group） and large-dose group（control group） by the random number table.Based on endoscopic hemostasis，the study group received 3-day management including intravenous injection of esomeprazole sodium 80 mg combined with intravenous drip of esomeprazole sodium 40 mg，once every 12 hours，and the control group received 3-day management consisting of intravenous injection of esomeprazole sodium 80 mg combined with continuous infusion of esomeprazole sodium 8 mg/h by the infusion pump.We compared the indicators for evaluating the treatment effectiveness such as mean time needed for bleeding to stop，mean amount of blood transfusion，rate of re-bleeding，mean length of stay，rate of having adverse events，and rate of receiving surgical intervention between the groups.Results　Both groups showed no significant differences in the aforementioned indicators for evaluating the treatment effectiveness（P>0.05）.Conclusion　Although both regimens achieved similar hemostatic effects，we recommend intravenous administration of standard dose of esomeprazole sodium in combination with endoscopic hemostasis，for it uses less medical resources.

Key words: Peptic ulcer hemorrhage, Gastroscopy, Omeprazole, Hemostasis, Dose, Treatment outcome

摘要： 目的　比较内镜下止血联合不同剂量注射用艾司奥美拉唑钠治疗急性消化性溃疡出血的临床效果。方法　选取2016年1月—2018年1月武警总医院消化内科收治的160例急性消化性溃疡出血患者，采用随机数字表法将其分为标准剂量组（研究组）和大剂量组（对照组），各80例。所有患者接受内镜下止血治疗。研究组给予注射用艾司奥美拉唑钠80 mg静脉注射+40 mg静脉滴注，每12 h 1次，维持治疗72 h。对照组给予注射用艾司奥美拉唑钠80 mg静脉注射+8 mg/h静脉持续泵入，维持治疗72 h。对比两组患者的平均止血时间、平均输血量、再出血率、平均住院时间、不良反应发生率及手术干预情况。结果　两组平均止血时间、平均输血量、再出血率、平均住院时间、不良反应发生率以及转外科手术率比较，差异均无统计学意义（P>0.05）。结论　对于急性消化性溃疡出血患者，内镜下止血联合标准剂量注射用艾司奥美拉唑钠间歇静脉滴注与大剂量持续泵入的止血效果相当，但前者更有利于减少医疗资源，值得临床应用与推广。

关键词: 消化性溃疡出血, 胃镜检查, 奥美拉唑, 止血, 剂量, 治疗结果