Abstract: Objective　To investigate the risk factors，etiological type and prognosis of pontine infarction patients of different age groups.Methods　We enrolled 74 pontion infarction patients from Department of Neurology，Beijing Zhongguancun Hospital from March 2015 to March 2017 and assigned 37 younger than 65 years old of them to the young-to-middle-aged group，and other 37 aged ≥65 to elderly group，respectively.We collected and analyzed their baseline characteristics，such as demographic data，past medical history，laboratory findings and imaging findings as well as modified Rankin Scale （mRS） score.Results　Compared with the young-to-middle-aged group，elderly group demonstrated higher percentage of patients with diabetes but lower percentage of patients with hyperlipidemia（P<0.05）.Moreover，elderly patients were found with higher levels of mean glycosylated hemoglobin and systolic pressure and lower level of mean triacylglycerol（P<0.05）.Two groups presented no significant differences in types of etiology for pontine infarction（χ2=2.303，P=0.316）.To be specific，young-to-middle-aged group and elderly group showed similar prevalence of large-artery-occlusive disease-related pontine infarction〔5.4%（2/37） vs.16.2%（6/37）〕，similar prevalence of basilar artery branch disease related-pontine infarction〔45.9%（17/37） vs.43.3%（16/37）〕 and similar prevalence of small vessel disease-related pontine infarction〔48.7% （18/37） vs.40.5% （15/37）〕.Young-to-middle-aged group and elderly group also presented similar rate of poor short-term prognosis〔27.0% （10/37） vs.29.7% （11/37）〕（χ2=0.111，P>0.05）.Conclusion　Hypertension，hyperlipidemia，and history of smoking and drinking were major risk factors for pontion infarction in young-to-middle-aged people，while diabetes was the major risk factor for pontion infarction in elderly people.Pontion infarction in young-to-middle-aged people was mainly due to small vessel disease，whereas that in elderly people was mainly due to basilar artery branch disease.Poor short-term prognosis was found in 1/3 of the young-to-middle-aged patients and elderly patients with pontion infarction.

Key words: Brain infarction, Young adult, Middle aged, Aged, Risk factors, Prognosis

摘要： 目的　探讨不同年龄脑桥梗死患者的危险因素、病因分型和预后。方法　回顾性分析2015年3月—2017年3月北京市中关村医院神经内科收治的脑桥梗死患者74例，以年龄65岁为界，将其分为青中年组（年龄<65岁）37例和老年组（年龄≥65岁）37例。收集患者入院时基线资料、既往史及个人史、化验指标、影像学资料及改良Rankin量表（mRS）评分。结果　老年组糖尿病所占比例高于青中年组，高脂血症所占比例低于青中年组（P<0.05）。老年组糖化血红蛋白、收缩压高于青中年组，三酰甘油低于青中年组（P<0.05）。青中年组病因为大动脉闭塞性2例（5.4%），基底动脉分支病变17例（45.9%），小血管病变18例（48.7%）；老年组病因为大动脉闭塞性6例（16.2%），基底动脉分支病变16例（43.3%），小血管病变15例（40.5%）。两组病因分型比较，差异无统计学意义（χ2=2.303，P=0.316）。青中年组短期预后不良10例（27.0%），老年组为11例（29.7%）。两组短期预后不良发生率比较，差异无统计学意义（χ2=0.111，P>0.05）。结论　青中年组主要危险因素为高血压、高脂血症、吸烟及饮酒史等；而老年组相比青中年组，糖尿病因素更突出。青中年组主要病因为小血管病变，老年组主要病因为基底动脉分支病变。青中年组及老年组约有1/3的患者短期预后不良。

关键词: 脑梗死, 青年人, 中年人, 老年人, 危险因素, 预后