The incidence and mortality rates of coronary heart disease combined with hypertension in China have been steadily rising, posing a significant threat to public health security. Consequently, it is essential to standardize and synthesize the treatment protocols for coronary heart disease combined with hypertension within the framework of traditional Chinese medicine (TCM), thereby providing a robust data foundation for clinical differential diagnosis and management as well as for the development of consensus guidelines.

This study aims to investigate the formulation and compatibility rules of coronary heart disease combined with hypertension utilizing latent structure modeling in conjunction with association rule mining.

The search period for this research extends from the establishment of the database until May 31, 2024, a systematic search was conducted in CNKI, VIP, Wanfang Data and SinoMed databases, the literature on TCM decoction for coronary heart disease complicated with hypertension was screened using EndNote software. Standardized data were imported into Microsoft Excel 2019 to establish a TCM database, lantern 5.0 and Rstudio were used for analyzing the hidden structure model and association rules of high-frequency TCM.

In the end, a total of 122 TCM prescriptions were included, involving 104 medicinals with cumulative use frequency of 1 390, the high-frequency Chinese medicines identified were salvia miltiorrhizomes, Chuanxiong, achyranthus rhizome, red peony root and Yujin, which primarily exerted tonifying effects on deficiencies and promoting blood circulation. Through hidden structure analysis, a total of 19 latent variables, 38 latent categories, 5 comprehensive cluster models and 16 core formulas were obtained, decoctions deduced syndrome types for coronary heart disease complicated with hypertension, common witnessed types included Qi deficiency and blood stasis, Yin deficiency and blood stasis as well as phlegm dampness blocking. Association rule analysis yielded 43 strong association rules with the highest support degree observed between Achyrantha-Chuanxiong and the highest confidence degree between Yujin-Salvia miltiorrhiza.

Coronary heart disease combined with hypertension is a syndrome characterized by deficiency in nature and excess in superficiality, the core pathological mechanism is dominated by blood stasis, followed by deficiency and phlegm, it is closely related to liver, heart and spleen, treatment principles should focus on activating blood circulation while supplementing Qi, clearing phlegm while dispelling dampness, nourishing Yin while strengthening spleen, regulating Qi while soothing liver.

目前我国冠心病合并高血压患病率和死亡率逐年攀升，严重威胁我国公共卫生安全，规范并总结中医组方治疗冠心病合并高血压的方案刻不容缓，以期为临床辨证论治冠心病合并高血压及共识和指南的制订提供数据来源。

基于隐结构模型结合关联规则探索冠心病合并高血压的组方及配伍规律。

本研究检索时间为建库至2024-05-31，系统性检索中国知网、维普中文期刊服务平台、万方数据知识服务平台、中国生物医学文献数据库，通过EndNote软件筛选出中药汤剂治疗冠心病合并高血压的最终文献。运用Microsoft Excel 2019导入规范化的数据并建立中药数据库，应用Lantern 5.0和Rstudio软件对高频中药进行隐结构模型和关联规则分析。

最终纳入中医处方122首，涉及中药104味，中药累计使用频次为1 390次，高频中药（使用率>4%）为丹参、川芎、牛膝、赤芍、郁金等，功效以活血化瘀、补虚为主。隐结构分析共获得19个隐变量、38个隐类、5个综合聚类模型、16个核心方剂，以方测证来推断出冠心病合并高血压证型以气虚血瘀证、气滞血瘀证、阴虚血瘀证和痰湿闭阻证为常见证型。关联规则分析获取43条强关联规则，支持度最高为牛膝-川芎，置信度最高为郁金-丹参。

冠心病合并高血压为本虚标实之证，核心病机以"瘀"为主，"虚""痰"次之，与肝、心、脾三脏关系密切，当以活血补气、豁痰祛湿为治疗原则，随证结合滋阴健脾、理气疏肝治法。