Advances in the Application of Vagus Nerve Stimulation in Inflammation and Apoptosis Mechanism of Chronic Heart Failure

doi:10.12114/j.issn.1007-9572.2023.0693

Abstract

Abstract:

As a crucial component of the cardiac autonomic nervous system, the cardiac vagus nerve plays a significant role in the management of chronic heart failure. In recent years, several studies have found that vagus nerve stimulation protects cardiac function and delays the progression of chronic heart failure by reducing the expression of inflammatory factors and related proteins, apoptosis-related proteins, and improving myocardial function and ventricular remodeling. However, there are limited reports related to the mechanism of inflammation and apoptosis of the vagus nerve in chronic heart failure. Hence, this article reviews the anatomy of the cardiac vagus nerve, potential treatment mechanisms, practical parameters of vagus nerve stimulation, and the recent applications and clinical progress of vagus nerve stimulation in inflammation and apoptosis mechanisms in chronic heart failure, in order to provide a reference for the future related research.

Key words: Heart failure, Vagus nerve stimulation, Chronic heart failure, Inflammation, Apoptosis, Review

摘要：

心迷走神经作为心脏自主神经系统重要的神经，对于慢性心力衰竭的治疗有着重要的作用。近年来，多个研究发现迷走神经刺激通过减少炎性因子及相关蛋白的表达、凋亡相关蛋白的表达，来改善心肌功能及心室重塑等，从而对心脏功能进行保护，延缓慢性心力衰竭的进展。然而，关于迷走神经在慢性心力衰竭炎症及凋亡机制的相关报道较少，因此本文综述了心迷走神经的解剖、治疗的可能机制、迷走神经刺激实用参数以及近年来有关迷走神经刺激在慢性心力衰竭炎症和凋亡机制中的应用和最新临床进展，为后续相关研究开展提供借鉴。

关键词: 心力衰竭, 迷走神经刺激术, 慢性心力衰竭, 炎症, 凋亡, 综述

CLC Number:

R 541.62

HU Yuchi,DAI Songyuan,ZHAO Ling, et al. Advances in the Application of Vagus Nerve Stimulation in Inflammation and Apoptosis Mechanism of Chronic Heart Failure[J]. Chinese General Practice, 2024, 27(24): 3044-3050. DOI: 10.12114/j.issn.1007-9572.2023.0693.
胡宇驰,代松源,赵玲等. 迷走神经刺激在慢性心力衰竭炎症及凋亡机制中的应用研究进展[J]. 中国全科医学, 2024, 27(24): 3044-3050. DOI: 10.12114/j.issn.1007-9572.2023.0693.

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