Chinese General Practice ›› 2024, Vol. 27 ›› Issue (06): 723-732.DOI: 10.12114/j.issn.1007-9572.2023.0449
Special Issue: 中医最新文章合集
• Original Research • Previous Articles Next Articles
Received:
2023-06-12
Revised:
2023-08-20
Published:
2024-02-20
Online:
2023-11-21
Contact:
WANG Chunai
通讯作者:
王春爱
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0449
组别 | 只数 | 第1天 | 第2天 | 第3天 | 第4天 | 第5天 |
---|---|---|---|---|---|---|
对照组术后3 d亚组 | 11 | 89.01±14.95 | 56.72±19.55 | 42.25±17.55 | 27.72±10.25 | 23.68±8.89 |
模型组术后3 d亚组 | 12 | 94.83±18.17 | 55.49±24.96 | 38.38±25.10 | 30.14±17.67 | 24.09±5.31 |
电针组术后3 d亚组 | 11 | 90.99±18.35 | 61.82±19.23 | 36.31±16.19 | 24.90±10.31 | 22.18±8.87 |
F值 | F交互=0.469,F组间=0.046,F时间=126.000 | |||||
P值 | P交互=0.876,P组间=0.956,P时间<0.001 |
Table 1 Comparison of cognitive function training escape latency in 3 d postoperative subgroups
组别 | 只数 | 第1天 | 第2天 | 第3天 | 第4天 | 第5天 |
---|---|---|---|---|---|---|
对照组术后3 d亚组 | 11 | 89.01±14.95 | 56.72±19.55 | 42.25±17.55 | 27.72±10.25 | 23.68±8.89 |
模型组术后3 d亚组 | 12 | 94.83±18.17 | 55.49±24.96 | 38.38±25.10 | 30.14±17.67 | 24.09±5.31 |
电针组术后3 d亚组 | 11 | 90.99±18.35 | 61.82±19.23 | 36.31±16.19 | 24.90±10.31 | 22.18±8.87 |
F值 | F交互=0.469,F组间=0.046,F时间=126.000 | |||||
P值 | P交互=0.876,P组间=0.956,P时间<0.001 |
组别 | 只数 | 第1天 | 第2天 | 第3天 | 第4天 | 第5天 |
---|---|---|---|---|---|---|
对照组术后7 d亚组 | 12 | 87.82±21.73 | 58.45±25.88 | 37.79±16.06 | 27.37±15.46 | 21.96±8.21 |
模型组术后7 d亚组 | 11 | 86.78±27.43 | 57.71±28.77 | 42.15±22.49 | 27.27±14.48 | 20.21±4.08 |
电针组术后7 d亚组 | 11 | 94.19±18.24 | 60.58±35.51 | 36.95±19.26 | 24.24±12.35 | 19.89±12.93 |
F值 | F交互=0.344,F组间=0.003,F时间=109.200 | |||||
P值 | P交互=0.947,P组间=0.997,P时间<0.001 |
Table 2 Comparison of cognitive function training escape latency in 7 d postoperative subgroups
组别 | 只数 | 第1天 | 第2天 | 第3天 | 第4天 | 第5天 |
---|---|---|---|---|---|---|
对照组术后7 d亚组 | 12 | 87.82±21.73 | 58.45±25.88 | 37.79±16.06 | 27.37±15.46 | 21.96±8.21 |
模型组术后7 d亚组 | 11 | 86.78±27.43 | 57.71±28.77 | 42.15±22.49 | 27.27±14.48 | 20.21±4.08 |
电针组术后7 d亚组 | 11 | 94.19±18.24 | 60.58±35.51 | 36.95±19.26 | 24.24±12.35 | 19.89±12.93 |
F值 | F交互=0.344,F组间=0.003,F时间=109.200 | |||||
P值 | P交互=0.947,P组间=0.997,P时间<0.001 |
组别 | 只数 | 逃避潜伏期[M(P25,P75),s] | 穿越平台次数(次) | 目标象限停留时间(s) | 平均游泳速度(cm/s) |
---|---|---|---|---|---|
对照组术后3 d亚组 | 11 | 15.66(13.34,25.77) | 10.82±3.95 | 50.77±11.09 | 24.14±3.56 |
模型组术后3 d亚组 | 12 | 55.67(36.54,67.66)b | 3.92±1.73b | 35.50±7.55b | 24.73±3.86 |
电针组术后3 d亚组 | 11 | 27.11(23.29,32.77)c | 7.27±2.33bc | 46.82±9.51c | 27.03±5.42 |
F(H)值 | 19.410a | 17.460 | 8.185 | 1.372 | |
P值 | <0.001 | <0.001 | 0.010 | 0.269 |
Table 3 Comparison of learning and memory of rats in 3 d postoperative subgroups
组别 | 只数 | 逃避潜伏期[M(P25,P75),s] | 穿越平台次数(次) | 目标象限停留时间(s) | 平均游泳速度(cm/s) |
---|---|---|---|---|---|
对照组术后3 d亚组 | 11 | 15.66(13.34,25.77) | 10.82±3.95 | 50.77±11.09 | 24.14±3.56 |
模型组术后3 d亚组 | 12 | 55.67(36.54,67.66)b | 3.92±1.73b | 35.50±7.55b | 24.73±3.86 |
电针组术后3 d亚组 | 11 | 27.11(23.29,32.77)c | 7.27±2.33bc | 46.82±9.51c | 27.03±5.42 |
F(H)值 | 19.410a | 17.460 | 8.185 | 1.372 | |
P值 | <0.001 | <0.001 | 0.010 | 0.269 |
组别 | 只数 | 逃避潜伏期(s) | 穿越平台次数(次) | 目标象限停留时间(s) | 平均游泳速度(cm/s) |
---|---|---|---|---|---|
对照组术后7 d亚组 | 12 | 22.83±12.75 | 8.92±3.50 | 48.12±7.94 | 25.90±4.39 |
模型组术后7 d亚组 | 11 | 39.60±16.22a | 5.64±1.80a | 37.49±8.51a | 23.63±7.19 |
电针组术后7 d亚组 | 11 | 24.29±9.91b | 8.73±3.17 | 49.67±6.63b | 28.03±3.78 |
F值 | 5.550 | 4.396 | 8.153 | 1.896 | |
P值 | 0.009 | 0.021 | 0.010 | 0.167 |
Table 4 Comparison of learning and memory of rats in 7 d postoperative subgroups
组别 | 只数 | 逃避潜伏期(s) | 穿越平台次数(次) | 目标象限停留时间(s) | 平均游泳速度(cm/s) |
---|---|---|---|---|---|
对照组术后7 d亚组 | 12 | 22.83±12.75 | 8.92±3.50 | 48.12±7.94 | 25.90±4.39 |
模型组术后7 d亚组 | 11 | 39.60±16.22a | 5.64±1.80a | 37.49±8.51a | 23.63±7.19 |
电针组术后7 d亚组 | 11 | 24.29±9.91b | 8.73±3.17 | 49.67±6.63b | 28.03±3.78 |
F值 | 5.550 | 4.396 | 8.153 | 1.896 | |
P值 | 0.009 | 0.021 | 0.010 | 0.167 |
组别 | 只数 | IL-6 | TNF-α | IL-10[M(P25,P75)] |
---|---|---|---|---|
对照组术后3 d亚组 | 11 | 19.59±9.01 | 233.20±24.53 | 38.25(36.56,43.88) |
模型组术后3 d亚组 | 12 | 54.19±14.98b | 390.10±47.78b | 80.25(73.08,87.57)b |
电针组术后3 d亚组 | 11 | 34.26±15.72c | 308.50±48.90bc | 159.50(135.60,172.80)bc |
F(H)值 | 18.750 | 39.910 | 29.110a | |
P值 | <0.001 | <0.001 | <0.001 |
Table 5 Comparison of serum IL-6,TNF-α and IL-10 levels in 3 d postoperative subgroups
组别 | 只数 | IL-6 | TNF-α | IL-10[M(P25,P75)] |
---|---|---|---|---|
对照组术后3 d亚组 | 11 | 19.59±9.01 | 233.20±24.53 | 38.25(36.56,43.88) |
模型组术后3 d亚组 | 12 | 54.19±14.98b | 390.10±47.78b | 80.25(73.08,87.57)b |
电针组术后3 d亚组 | 11 | 34.26±15.72c | 308.50±48.90bc | 159.50(135.60,172.80)bc |
F(H)值 | 18.750 | 39.910 | 29.110a | |
P值 | <0.001 | <0.001 | <0.001 |
组别 | 只数 | IL-6[M(P25,P75)] | TNF-α | IL-10 |
---|---|---|---|---|
对照组术后7 d亚组 | 12 | 22.54(11.02,27.43) | 201.90±39.48 | 37.71±5.70 |
模型组术后7 d亚组 | 11 | 39.76(26.78,49.81)b | 336.10±85.63b | 50.69±9.08b |
电针组术后7 d亚组 | 11 | 25.45(12.17,38.67) | 248.60±41.62c | 80.89±16.12bc |
F(H)值 | 9.622a | 15.200 | 45.680 | |
P值 | 0.008 | <0.001 | <0.001 |
Table 6 Comparison of serum IL-6,TNF-α and IL-10 levels in 7 d postoperative subgroups
组别 | 只数 | IL-6[M(P25,P75)] | TNF-α | IL-10 |
---|---|---|---|---|
对照组术后7 d亚组 | 12 | 22.54(11.02,27.43) | 201.90±39.48 | 37.71±5.70 |
模型组术后7 d亚组 | 11 | 39.76(26.78,49.81)b | 336.10±85.63b | 50.69±9.08b |
电针组术后7 d亚组 | 11 | 25.45(12.17,38.67) | 248.60±41.62c | 80.89±16.12bc |
F(H)值 | 9.622a | 15.200 | 45.680 | |
P值 | 0.008 | <0.001 | <0.001 |
组别 | 只数 | IL-6 | TNF-α | IL-10 |
---|---|---|---|---|
对照组术后3 d亚组 | 5 | 34.35±3.94 | 45.22±4.60 | 13.06±0.96 |
模型组术后3 d亚组 | 5 | 88.79±3.93a | 148.10±12.78a | 33.74±2.17a |
电针组术后3 d亚组 | 5 | 55.96±3.66ab | 93.62±16.31ab | 57.48±3.77ab |
F值 | 254.000 | 88.200 | 373.800 | |
P值 | <0.001 | <0.001 | <0.001 |
Table 7 Comparison of IL-6,TNF-α and IL-10 levels in hippocampus in 3 d postoperative subgroups
组别 | 只数 | IL-6 | TNF-α | IL-10 |
---|---|---|---|---|
对照组术后3 d亚组 | 5 | 34.35±3.94 | 45.22±4.60 | 13.06±0.96 |
模型组术后3 d亚组 | 5 | 88.79±3.93a | 148.10±12.78a | 33.74±2.17a |
电针组术后3 d亚组 | 5 | 55.96±3.66ab | 93.62±16.31ab | 57.48±3.77ab |
F值 | 254.000 | 88.200 | 373.800 | |
P值 | <0.001 | <0.001 | <0.001 |
组别 | 只数 | IL-6 | TNF-α | IL-10 |
---|---|---|---|---|
对照组术后7 d亚组 | 5 | 30.29±2.21 | 43.98±2.82 | 11.69±0.78 |
模型组术后7 d亚组 | 5 | 58.52±5.10a | 88.99±12.32a | 25.78±1.90a |
电针组术后7 d亚组 | 5 | 35.73±3.31b | 50.21±2.45b | 37.78±3.75ab |
F值 | 80.490 | 53.860 | 140.200 | |
P值 | <0.001 | <0.001 | <0.001 |
Table 8 Comparison of IL-6,TNF-α and IL-10 levels in hippocampus in 7 d postoperative subgroups
组别 | 只数 | IL-6 | TNF-α | IL-10 |
---|---|---|---|---|
对照组术后7 d亚组 | 5 | 30.29±2.21 | 43.98±2.82 | 11.69±0.78 |
模型组术后7 d亚组 | 5 | 58.52±5.10a | 88.99±12.32a | 25.78±1.90a |
电针组术后7 d亚组 | 5 | 35.73±3.31b | 50.21±2.45b | 37.78±3.75ab |
F值 | 80.490 | 53.860 | 140.200 | |
P值 | <0.001 | <0.001 | <0.001 |
组别 | 只数 | Fe2+ | LPO | ACSL4 | FTH1 | LPCAT3 |
---|---|---|---|---|---|---|
对照组术后3 d亚组 | 5 | 1.03±0.12 | 0.99±0.17 | 0.66±0.05 | 1.20±0.10 | 0.46±0.04 |
模型组术后3 d亚组 | 5 | 1.77±0.19a | 2.82±0.24a | 1.27±0.08a | 0.60±0.04a | 1.20±0.13a |
电针组术后3 d亚组 | 5 | 1.39±0.11ab | 1.85±0.23ab | 0.86±0.06ab | 0.78±0.03ab | 0.86±0.12ab |
F值 | 33.680 | 89.120 | 110.300 | 120.700 | 63.600 | |
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
Table 9 Comparison of relative expression levels of Fe2+,LPO,ACSL4,FTH1,and LPCAT3 in 3 d postoperative subgroups
组别 | 只数 | Fe2+ | LPO | ACSL4 | FTH1 | LPCAT3 |
---|---|---|---|---|---|---|
对照组术后3 d亚组 | 5 | 1.03±0.12 | 0.99±0.17 | 0.66±0.05 | 1.20±0.10 | 0.46±0.04 |
模型组术后3 d亚组 | 5 | 1.77±0.19a | 2.82±0.24a | 1.27±0.08a | 0.60±0.04a | 1.20±0.13a |
电针组术后3 d亚组 | 5 | 1.39±0.11ab | 1.85±0.23ab | 0.86±0.06ab | 0.78±0.03ab | 0.86±0.12ab |
F值 | 33.680 | 89.120 | 110.300 | 120.700 | 63.600 | |
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
组别 | 只数 | Fe2+ | LPO | ACSL4 | FTH1 | LPCAT3 |
---|---|---|---|---|---|---|
对照组术后7 d亚组 | 5 | 1.01±0.16 | 1.00±0.10 | 0.83±0.03 | 1.08±0.11 | 0.62±0.09 |
模型组术后7 d亚组 | 5 | 1.50±0.13a | 1.50±0.24a | 1.05±0.07a | 0.71±0.07a | 1.06±0.09a |
电针组术后7 d亚组 | 5 | 1.09±0.13b | 1.12±0.11b | 0.89±0.07b | 1.02±0.10b | 0.68±0.08b |
F值 | 18.300 | 13.010 | 16.590 | 22.910 | 39.240 | |
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
Table 10 Comparison of relative expression levels of Fe2+,LPO,ACSL4,FTH1,and LPCAT3 in 7 d postoperative subgroups
组别 | 只数 | Fe2+ | LPO | ACSL4 | FTH1 | LPCAT3 |
---|---|---|---|---|---|---|
对照组术后7 d亚组 | 5 | 1.01±0.16 | 1.00±0.10 | 0.83±0.03 | 1.08±0.11 | 0.62±0.09 |
模型组术后7 d亚组 | 5 | 1.50±0.13a | 1.50±0.24a | 1.05±0.07a | 0.71±0.07a | 1.06±0.09a |
电针组术后7 d亚组 | 5 | 1.09±0.13b | 1.12±0.11b | 0.89±0.07b | 1.02±0.10b | 0.68±0.08b |
F值 | 18.300 | 13.010 | 16.590 | 22.910 | 39.240 | |
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
[1] |
|
[2] |
|
[3] |
|
[4] |
中华医学会麻醉学分会老年人麻醉学组,国家老年疾病临床医学研究中心,中华医学会精神病学分会,等. 中国老年患者围术期脑健康多学科专家共识(二)[J]. 中华医学杂志,2019,99(29):2252-2269. DOI:10.3760/cma.j.issn.0376-2491.2019.29.004.
|
[5] |
|
[6] |
|
[7] |
秦晓宇,王春爱. 术后认知功能障碍新机制铁死亡的研究进展[J]. 生命科学研究,2022,26(6):501-508. DOI:10.16605/j.cnki.1007-7847.2022.03.0125.
|
[8] |
邓福谋,罗晓东,郎海丽,等. β-淀粉样蛋白在老龄大鼠术后认知功能障碍中的作用及石杉碱甲的干预作用[J]. 中国老年学杂志,2018,38(24):6034-6036. DOI:10.3969/j.issn.1005-9202.2018.24.057.
|
[9] |
牛聪. 电针预刺激对术后认知功能的影响及其机制的研究[D]. 南京:南京中医药大学,2022.
|
[10] |
|
[11] |
中国针灸学会. 实验动物常用穴位名称与定位第2部分:大鼠[J]. 针刺研究,2021,46(4):351-352.
|
[12] |
白雪,范欣怡,苏帆. 老年患者术后认知功能障碍的中医病机探讨[J]. 中国中西医结合外科杂志,2019,25(1):116-119. DOI:10.3969/j.issn.1007-6948.2019.01.030.
|
[13] |
|
[14] |
|
[15] |
|
[16] |
|
[17] |
|
[18] |
|
[19] |
|
[20] |
|
[21] |
|
[22] |
|
[23] |
|
[24] |
|
[25] |
吴建丽,于致顺,魏庆双,等. 浅谈"医工结合"对针灸针具改革的影响[J]. 中华中医药杂志,2018,33(12):5409-5411.
|
[26] |
秦晓宇,逯晓婷,段蓉蓉,等. 电针复合全身麻醉对胃肠道肿瘤切除术后认知功能障碍影响的Meta分析[J]. 湖南中医杂志,2022,38(10):122-128. DOI:10.16808/j.cnki.issn1003-7705.2022.10.034.
|
[27] |
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