With the advancement of modern neuroimaging and neuronavigation techniques, frameless intracranial biopsy techniques have been increasingly used.

To assess the application value of a neuronavigation system using 3.0T magnetic resonance imaging (MRI) in frameless stereotactic brain biopsies.

Twenty-seven patients with intracranial lesions were recruited in the Department of Neurosurgery, People's Hospital of Xinjiang Uygur Autonomous Region from March 2018 to June 2021. All of them underwent brain MRI at 3.0T, then registered for using the Medtronic Stealth Station S7 neuronavigation system to implement frameless stereotactic brain biopsies. Pre-biopsy data, post-biopsy complications and pathological diagnosis rate were reviewed retrospectively.

In all, 27 biopsies were performed in these 27 cases, among which anaplastic astrocytoma and large B-cell lymphoma accounted for 33.3% (9/27) , and 18.5% (5/27) , respectively. Twenty-six cases obtained a definite diagnosis by frameless stereotactic brain biopsies, with a rate of pathological diagnosis of 96.3%. During the brain biopsy, puncture tract bleeding occurred in two cases (7.4%) , and one of them was confirmed with serious bleeding by post-biopsy brain CT. Five cases had post-biopsy complications (18.5%) , four of them had intracranial hemorrhage (14.8%) , and the other one case had pulmonary infection (3.7%) . No death occurred in the biopsy.

This kind of frameless stereotactic brain biopsy is safe and effective with a high diagnostic rate.

随着现代神经影像学和神经导航技术的进步，无框架脑活检技术在当今越来越普及。

探讨基于3.0T磁共振注册的神经导航系统在无框架立体定向颅内病变活检术中的应用。

选取2018年3月至2021年6月在新疆维吾尔自治区人民医院神经外科住院的27例颅内病变患者为研究对象，患者术前行3.0T磁共振扫描，注册并应用美敦力Stealth S7神经导航系统行无框架立体定向颅内病变活检术。回顾性分析患者的术前资料、术后并发症、病理诊断率等资料。

对27例患者进行了无框架立体定向颅内病变活检术，其中间变性星形细胞瘤占33.3%（9/27），大B细胞淋巴瘤占18.5%（5/27）。26例（96.3%）患者经立体定向活检术明确病理诊断，术中穿刺道出血发生率为7.4%（2/27）；术后并发症发生率为18.5%（5/27），术后颅内出血发生率为14.8%（4/27），术后肺部感染发生率为3.7%（1/27）；无死亡病例。

基于3.0T磁共振注册的神经导航系统下无框架立体定向颅内病变活检术是一种安全有效的方法，具有较高的诊断率。