Chinese General Practice ›› 2022, Vol. 25 ›› Issue (29): 3658-3663.DOI: 10.12114/j.issn.1007-9572.2022.0429
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Received:
2022-04-21
Revised:
2022-07-04
Published:
2022-10-15
Online:
2022-07-21
Contact:
Li LIAO
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通讯作者:
廖力
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0429
项目 | 肌少症组(n=44) | 非肌少症组(n=284) | 检验统计量值 | P值 | |
---|---|---|---|---|---|
性别〔n(%)〕 | 6.549 | 0.010 | |||
男 | 20(45.5) | 186(65.5) | |||
女 | 24(54.5) | 98(34.5) | |||
年龄( | 64.2±10.8 | 60.5±11.2 | 2.073a | 0.039 | |
糖尿病〔n(%)〕 | 7(15.9) | 21(7.4) | 3.538 | 0.060 | |
高血压〔n(%)〕 | 8(18.2) | 47(16.5) | 0.073 | 0.787 | |
冠心病〔n(%)〕 | 4(9.1) | 9(3.2) | 3.510 | 0.061 | |
脑血管疾病〔n(%)〕 | 3(6.8) | 9(3.2) | 1.439 | 0.230 | |
NRS2002≥3分〔n(%)〕 | 27(61.4) | 118(41.5) | 6.064 | 0.014 | |
内科合并症指数( | 4.57±1.74 | 4.54±4.39 | 0.039a | 0.969 | |
ASA分级≥3级〔n(%)〕 | 18(40.9) | 127(44.7) | 0.224 | 0.636 | |
腹部手术史〔n(%)〕 | 15(34.1) | 46(16.2) | 8.058 | 0.005 | |
化疗史〔n(%)〕 | 3(6.8) | 43(15.1) | 2.189 | 0.139 | |
术前血清白蛋白( | 38.27±6.00 | 40.00±5.35 | -2.253a | 0.028 | |
术前血红蛋白( | 111.52±20.48 | 112.59±22.22 | -0.627a | 0.510 | |
术前C反应蛋白〔M(P25,P75),mg/L〕 | 5.45(1.53,22.13) | 2.70(0.64,10.40) | -1.944b | 0.052 | |
肿瘤分化程度〔n(%)〕 | 10.212 | 0.037 | |||
低分化 | 4(9.1) | 4(1.4) | |||
中分化 | 22(50.0) | 174(61.3) | |||
高分化 | 5(14.7) | 29(10.2) | |||
低中分化 | 3(6.8) | 20(7.0) | |||
高中分化 | 10(22.7) | 57(20.1) | |||
神经侵犯〔n(%)〕 | 3(6.8) | 29(10.2) | 0.498 | 0.480 | |
脉管癌栓侵犯〔n(%)〕 | 2(4.5) | 17(6.0) | 0.145 | 0.704 | |
AJCC肿瘤分期〔n(%)〕 | 4.399 | 0.222 | |||
Ⅰ期 | 0 | 23(8.1) | |||
Ⅱ期 | 19(43.2) | 94(33.1) | |||
Ⅲ期 | 19(43.2) | 134(47.2) | |||
Ⅳ期 | 6(13.6) | 33(11.6) |
Table 1 Comparison of general data between colorectal cancer patients with and without CT-assessed sarcopenia
项目 | 肌少症组(n=44) | 非肌少症组(n=284) | 检验统计量值 | P值 | |
---|---|---|---|---|---|
性别〔n(%)〕 | 6.549 | 0.010 | |||
男 | 20(45.5) | 186(65.5) | |||
女 | 24(54.5) | 98(34.5) | |||
年龄( | 64.2±10.8 | 60.5±11.2 | 2.073a | 0.039 | |
糖尿病〔n(%)〕 | 7(15.9) | 21(7.4) | 3.538 | 0.060 | |
高血压〔n(%)〕 | 8(18.2) | 47(16.5) | 0.073 | 0.787 | |
冠心病〔n(%)〕 | 4(9.1) | 9(3.2) | 3.510 | 0.061 | |
脑血管疾病〔n(%)〕 | 3(6.8) | 9(3.2) | 1.439 | 0.230 | |
NRS2002≥3分〔n(%)〕 | 27(61.4) | 118(41.5) | 6.064 | 0.014 | |
内科合并症指数( | 4.57±1.74 | 4.54±4.39 | 0.039a | 0.969 | |
ASA分级≥3级〔n(%)〕 | 18(40.9) | 127(44.7) | 0.224 | 0.636 | |
腹部手术史〔n(%)〕 | 15(34.1) | 46(16.2) | 8.058 | 0.005 | |
化疗史〔n(%)〕 | 3(6.8) | 43(15.1) | 2.189 | 0.139 | |
术前血清白蛋白( | 38.27±6.00 | 40.00±5.35 | -2.253a | 0.028 | |
术前血红蛋白( | 111.52±20.48 | 112.59±22.22 | -0.627a | 0.510 | |
术前C反应蛋白〔M(P25,P75),mg/L〕 | 5.45(1.53,22.13) | 2.70(0.64,10.40) | -1.944b | 0.052 | |
肿瘤分化程度〔n(%)〕 | 10.212 | 0.037 | |||
低分化 | 4(9.1) | 4(1.4) | |||
中分化 | 22(50.0) | 174(61.3) | |||
高分化 | 5(14.7) | 29(10.2) | |||
低中分化 | 3(6.8) | 20(7.0) | |||
高中分化 | 10(22.7) | 57(20.1) | |||
神经侵犯〔n(%)〕 | 3(6.8) | 29(10.2) | 0.498 | 0.480 | |
脉管癌栓侵犯〔n(%)〕 | 2(4.5) | 17(6.0) | 0.145 | 0.704 | |
AJCC肿瘤分期〔n(%)〕 | 4.399 | 0.222 | |||
Ⅰ期 | 0 | 23(8.1) | |||
Ⅱ期 | 19(43.2) | 94(33.1) | |||
Ⅲ期 | 19(43.2) | 134(47.2) | |||
Ⅳ期 | 6(13.6) | 33(11.6) |
指标 | 肌少症组(n=44) | 非肌少症组(n=284) | χ2(t)值 | P值 |
---|---|---|---|---|
术中出血量≥200 ml〔n(%)〕 | 11(25.0) | 36(12.7) | 4.713 | 0.030 |
术后输白蛋白〔n(%)〕 | 18(40.9) | 73(25.7) | 4.394 | 0.036 |
术后输血〔n(%)〕 | 5(11.4) | 19(6.7) | 1.227 | 0.268 |
肠造口〔n(%)〕 | 23(52.3) | 115(40.5) | 2.169 | 0.141 |
SSI〔n(%)〕 | 12(27.3) | 35(12.3) | 6.935 | 0.008 |
再手术〔n(%)〕 | 4(9.1) | 9(3.2) | 3.510 | 0.061 |
总住院天数( | 22.80±12.00 | 19.15±8.57 | 3.263a | 0.002 |
术后住院天数( | 16.16±9.75 | 13.65±7.50 | 4.051a | <0.001 |
Table 2 Comparison of surgical outcome indicators between colorectal cancer patients with and without CT-assessed sarcopenia
指标 | 肌少症组(n=44) | 非肌少症组(n=284) | χ2(t)值 | P值 |
---|---|---|---|---|
术中出血量≥200 ml〔n(%)〕 | 11(25.0) | 36(12.7) | 4.713 | 0.030 |
术后输白蛋白〔n(%)〕 | 18(40.9) | 73(25.7) | 4.394 | 0.036 |
术后输血〔n(%)〕 | 5(11.4) | 19(6.7) | 1.227 | 0.268 |
肠造口〔n(%)〕 | 23(52.3) | 115(40.5) | 2.169 | 0.141 |
SSI〔n(%)〕 | 12(27.3) | 35(12.3) | 6.935 | 0.008 |
再手术〔n(%)〕 | 4(9.1) | 9(3.2) | 3.510 | 0.061 |
总住院天数( | 22.80±12.00 | 19.15±8.57 | 3.263a | 0.002 |
术后住院天数( | 16.16±9.75 | 13.65±7.50 | 4.051a | <0.001 |
变量 | β | SE | Wald χ2值 | P值 | OR值 | 95%CI |
---|---|---|---|---|---|---|
肌少症 | 1.202 | 0.430 | 7.825 | 0.005 | 3.325 | (1.433,7.717) |
性别 | 0.651 | 0.389 | 2.800 | 0.094 | 1.917 | (0.895,4.110) |
年龄 | -0.012 | 0.019 | 0.411 | 0.521 | 0.988 | (0.952,1.025) |
内科合并症指数 | 0.059 | 0.128 | 0.212 | 0.645 | 1.061 | (0.825,1.364) |
NRS2002≥3分 | -0.363 | 0.350 | 1.074 | 0.300 | 0.695 | (0.350,1.382) |
ASA分级≥3级 | 0.803 | 0.340 | 5.508 | 0.019 | 2.232 | (1.142,4.364) |
术前血清白蛋白 | 0.031 | 0.032 | 0.951 | 0.329 | 1.032 | (0.969,1.098) |
术前血红蛋白 | 0.007 | 0.008 | 0.687 | 0.407 | 1.007 | (0.991,1.023) |
术前C反应蛋白 | -0.002 | 0.003 | 0.220 | 0.639 | 0.998 | (0.992,1.005) |
术中出血量≥200 ml | -0.291 | 0.474 | 0.377 | 0.539 | 0.747 | (0.295,1.892) |
肠造口 | 0.804 | 0.348 | 5.330 | 0.021 | 2.235 | (1.129,4.424) |
常量 | -4.019 | 2.260 | 3.162 | 0.075 | 0.018 | — |
Table 3 Univariate Logistic regression analysis of the influencing factors of postoperative surgical site infection in patients with colorectal cancer
变量 | β | SE | Wald χ2值 | P值 | OR值 | 95%CI |
---|---|---|---|---|---|---|
肌少症 | 1.202 | 0.430 | 7.825 | 0.005 | 3.325 | (1.433,7.717) |
性别 | 0.651 | 0.389 | 2.800 | 0.094 | 1.917 | (0.895,4.110) |
年龄 | -0.012 | 0.019 | 0.411 | 0.521 | 0.988 | (0.952,1.025) |
内科合并症指数 | 0.059 | 0.128 | 0.212 | 0.645 | 1.061 | (0.825,1.364) |
NRS2002≥3分 | -0.363 | 0.350 | 1.074 | 0.300 | 0.695 | (0.350,1.382) |
ASA分级≥3级 | 0.803 | 0.340 | 5.508 | 0.019 | 2.232 | (1.142,4.364) |
术前血清白蛋白 | 0.031 | 0.032 | 0.951 | 0.329 | 1.032 | (0.969,1.098) |
术前血红蛋白 | 0.007 | 0.008 | 0.687 | 0.407 | 1.007 | (0.991,1.023) |
术前C反应蛋白 | -0.002 | 0.003 | 0.220 | 0.639 | 0.998 | (0.992,1.005) |
术中出血量≥200 ml | -0.291 | 0.474 | 0.377 | 0.539 | 0.747 | (0.295,1.892) |
肠造口 | 0.804 | 0.348 | 5.330 | 0.021 | 2.235 | (1.129,4.424) |
常量 | -4.019 | 2.260 | 3.162 | 0.075 | 0.018 | — |
变量 | β | SE | Wald χ2值 | P值 | OR值 | 95%CI |
---|---|---|---|---|---|---|
肌少症 | 0.978 | 0.397 | 6.062 | 0.014 | 2.659 | (1.221,5.791) |
ASA分级≥3级 | 0.785 | 0.334 | 5.535 | 0.019 | 2.192 | (1.140,4.216) |
肠造口 | 0.799 | 0.332 | 5.800 | 0.016 | 2.222 | (1.160,4.257) |
常量 | -2.354 | 0.985 | 5.716 | 0.017 | 0.095 | — |
Table 4 Multivariate Logistic regression analysis of the influencing factors of postoperative surgical site infection in patients with colorectal cancer
变量 | β | SE | Wald χ2值 | P值 | OR值 | 95%CI |
---|---|---|---|---|---|---|
肌少症 | 0.978 | 0.397 | 6.062 | 0.014 | 2.659 | (1.221,5.791) |
ASA分级≥3级 | 0.785 | 0.334 | 5.535 | 0.019 | 2.192 | (1.140,4.216) |
肠造口 | 0.799 | 0.332 | 5.800 | 0.016 | 2.222 | (1.160,4.257) |
常量 | -2.354 | 0.985 | 5.716 | 0.017 | 0.095 | — |
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