Effects of Music Therapy Assisted Anagliptin on Glycolipid Metabolism in Patients with Type 2 Diabetes

doi:10.12114/j.issn.1007-9572.2022.0271

Chinese General Practice ›› 2022, Vol. 25 ›› Issue (26): 3275-3280.DOI: 10.12114/j.issn.1007-9572.2022.0271

Special Issue: 内分泌代谢性疾病最新文章合辑

• Original Research • Previous Articles Next Articles

Effects of Music Therapy Assisted Anagliptin on Glycolipid Metabolism in Patients with Type 2 Diabetes

1. School of Rehabilitation Medicine, Capital Medical University, Beijing 100068, China
2. Department of Endocrine, Beijing Boai Hospital, China Rehabilitation Research Center, Beijing 100068, China
3. Music Therapy Center, Beijing Boai Hospital, China Rehabilitation Research Center, Beijing 100068, China
4. Department of Neurological Rehabilitation, Beijing Boai Hospital, China Rehabilitation Research Center, Beijing 100068, China

Received:2022-01-27 Revised:2022-05-25 Published:2022-09-15 Online:2022-07-06
Contact: Xin ZHENG
About author:
LI M X, ZHENG X, ZHANG X Y, et al. Effects of music therapy assisted anagliptin on glycolipid metabolism in patients with type 2 diabetes[J]. Chinese General Practice, 2022, 25 (26) : 3275-3280.

音乐辅助阿格列汀对2型糖尿病患者糖脂代谢的影响研究

1．100068　北京市，首都医科大学康复医学院
2．100068　北京市，中国康复研究中心北京博爱医院内分泌科
3．100068　北京市，中国康复研究中心北京博爱医院音乐治疗中心
4．100068　北京市，中国康复研究中心北京博爱医院神经康复科

通讯作者: 郑欣
作者简介:
作者贡献：李梅欣、郑欣负责文章的构思与设计、实施、记录、结果的分析与解释、撰写；张晓颖负责对音乐治疗内容的选择、指导；杜晓霞负责项目的申请及资金支持；郑欣负责文章的质量控制及审校，对文章整体负责。李梅欣，郑欣，张晓颖，等.音乐辅助阿格列汀对2型糖尿病患者糖脂代谢的影响研究[J].中国全科医学，2022，25（26）：3275-3280.[www.chinagp.net]
基金资助:
中国康复研究中心科研项目(2019zx-01)

Abstract

Abstract:

Background

Music therapy, as an emerging treatment, has a gradually evolving role in the rehabilitation of chronic diseases and is gaining increasing attention. But there are few studies on the effects of music therapy on diabetes rehabilitation.

Objective

To observe the effects of music assisted anagliptin on glycolipid metabolism in patients with type 2 diabetes.

Methods

Sixty five type 2 diabetic patients with poor glycemic control on oral agents who visited the outpatient clinic of Department of Endocrinology, Boai Hospital, China Rehabilitation Research Center, from October 2019 to February 2021 were selected. Patients were divided into group A (n=35) and group B (n=30) by random numbers, and patients in both groups maintained their original diet and exercise habits. Group A was treated with anagliptin tablets in combination with the original treatment (drug type, dose unchanged) , while group B was given music adjuvant therapy on the basis of group A. Patients in both groups were treated continuously for 12 weeks. Fasting plasma glucose (FPG) , glycated hemoglobin (HbA_1c) , low-density lipoprotein cholesterol (LDL-C) , total cholesterol (TC) , triacylglycerol (TG) , high-density lipoprotein cholesterol (HDL-C) , uric acid (UA) , 2 h postprandial plasma glucose (2 hPG) , hypersensitivity C-reactive protein (hs-CRP) , free fatty acids (FFA) , insulin resistance index (HOMA-IR) , β Cell function secretion index (HOMA-β) before and 12 weeks after treatment were compared between the two groups. The patients were observed for the occurrence of adverse reactions during the treatment.

Results

One patient was eliminated from the trial because of adverse drug reactions during the course of the trial in both groups, and 34 and 29 patients finally completed the trial in groups A and B, respectively. Patients in group B had lower 2 hPG than those in group A after 12 weeks of treatment (P<0.05) . FPG, HbA_1c, and 2 hPG were lower in both groups after 12 weeks of treatment whereas HOMA-β were higher after treatment (P<0.05) ; LDL-C and TC of group B patients after 12 weeks of treatment were lower (P<0.05) . No hypoglycemic events occurred in either group.

Conclusion

Music-assisted alagliptin can reduce postprandial blood glucose and improve lipid profile of type 2 diabetes patients more than that without music-assisted alagliptin. It also needs to be emphasized that the effects of music therapy must be based on diet control, proper exercise, and rational medication.

Key words: Diabetes mellitus, type 2, Hypoglycemic agents, Anagliptin, Music therapy, Dyslipidemias, Glycemic control, Treatment outcome

摘要：

背景

音乐治疗作为新兴的治疗方法，在慢性疾病康复中的应用逐渐兴起，且日益得到重视。但音乐治疗对糖尿病康复的效果研究尚少见报道。

目的

观察音乐辅助阿格列汀对2型糖尿病患者糖脂代谢的影响。

方法

选取2019年10月至2021年2月在中国康复研究中心北京博爱医院内分泌科门诊就诊的口服药物血糖控制不佳的2型糖尿病患者65例。采用随机数字表法将患者分为A组（n=35）和B组（n=30），两组患者均保持原有饮食、运动习惯。A组在原治疗（药物种类、剂量不变）基础上联用阿格列汀片治疗，B组在A组基础上给予音乐辅助治疗。两组患者均连续治疗12周。比较治疗前及治疗12周后两组患者空腹血糖（FPG）、糖化血红蛋白（HbA_1c）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）、餐后2 h血糖（2 hPG）、超敏C反应蛋白（hs-CRP）、游离脂肪酸（FFA）、胰岛素抵抗指数（HOMA-IR）、β细胞功能分泌指数（HOMA-β）；观察患者治疗过程中不良反应发生情况。

结果

两组试验过程中因药物不良反应均剔除1例患者，A组、B组最终分别有34、29例患者完成试验。B组患者治疗12周后2 hPG低于A组（P<0.05）。治疗12周后两组患者FPG、HbA_1c、2 hPG均低于组内治疗前，HOMA-β高于组内治疗前（P<0.05）；治疗12周后B组患者LDL-C、TC均低于组内治疗前（P<0.05）。两组均未发生低血糖事件。

结论

音乐辅助阿格列汀较无音乐辅助更能降低2型糖尿病患者的餐后血糖，改善血脂情况。需要强调的是，音乐治疗的效果一定是在饮食控制、适当运动、合理用药的基础上。

关键词: 糖尿病，2型, 降血糖药, 阿格列汀, 音乐治疗, 血脂异常, 血糖控制, 治疗结果

Meixin LI,Xin ZHENG,Xiaoying ZHANG, et al. Effects of Music Therapy Assisted Anagliptin on Glycolipid Metabolism in Patients with Type 2 Diabetes[J]. Chinese General Practice, 2022, 25(26): 3275-3280. DOI: 10.12114/j.issn.1007-9572.2022.0271.
李梅欣,郑欣,张晓颖等. 音乐辅助阿格列汀对2型糖尿病患者糖脂代谢的影响研究[J]. 中国全科医学, 2022, 25(26): 3275-3280. DOI: 10.12114/j.issn.1007-9572.2022.0271.

Figures/Tables 2

References 24

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组别	例数	年龄（岁）	性别（男/女）	病程（年）	BMI（kg/m²）	eGFR〔ml·min^-1·（1.73 m²）^-1〕	SBP（mm Hg）	DBP（mm Hg）
A组	34	58.3±12.1	20/14	8.9±2.0	24.8±3.6	94.47±19.28	134±15	78±11
B组	29	56.7±12.6	16/13	9.1±2.2	25.1±3.6	95.35±20.12	135±15	79±11
t（χ²）值		0.341	0.059^a	-0.781	0.331	0.551	-0.296	0.314
P值		0.736	0.803	0.435	0.750	0.597	0.769	0.755

组别	例数	年龄（岁）	性别（男/女）	病程（年）	BMI（kg/m²）	eGFR〔ml·min^-1·（1.73 m²）^-1〕	SBP（mm Hg）	DBP（mm Hg）
A组	34	58.3±12.1	20/14	8.9±2.0	24.8±3.6	94.47±19.28	134±15	78±11
B组	29	56.7±12.6	16/13	9.1±2.2	25.1±3.6	95.35±20.12	135±15	79±11
t（χ²）值		0.341	0.059^a	-0.781	0.331	0.551	-0.296	0.314
P值		0.736	0.803	0.435	0.750	0.597	0.769	0.755

组别	例数	FPG（mmol/L）				HbA_1c（%）				LDL-C（mmol/L）
组别	例数	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值
A组	34	8.20±1.19	7.29±1.17	2.295	0.031	7.92±0.75	7.22±0.61	2.941	0.008	2.48±0.77	2.40±0.71	0.151	0.201
B组	29	8.39±1.03	7.07±0.98	4.041	0.001	8.18±1.03	7.20±0.90	3.296	0.004	2.92±0.72	2.60±0.79	0.201	0.034
t（Z）值		1.163	-0.955			0.822	0.098			1.730	0.969
P值		0.252	0.346			0.416	0.922			0.092	0.339
组别	TC（mmol/L）				TG（mmol/L）				HDL-C（mmol/L）
组别	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值
A组	4.67±1.05	4.38±0.96	-1.749	0.096	1.78±1.02	1.55±0.97	0.644	0.527	1.16±0.32	1.18±0.21	-0.129	0.899
B组	4.83±0.92	4.36±0.98	0.255	0.001	1.85±1.16	1.60±0.85	0.787	0.441	1.17±0.21	1.24±0.24	-0.923	0.368
t（Z）值	0.482	0.319			0.325	0.182			0.355	0.957
P值	0.632	0.751			0.747	0.857			0.724	0.345
组别	UA（μmol/L）				2 hPG（mmol/L）				hs-CRP〔M（QR），mg/d〕
组别	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	Z值	P值
A组	360.92±29.11	327.00±21.85	1.661	0.123	11.60±1.70	9.72±1.65	3.979	0.001	0.12（0.27）	0.11（0.17）	0.541	0.594
B组	339.77±34.16	304.85±41.75	1.505	0.171	11.42±1.47	8.76±1.10	14.130	<0.001	0.11（0.18）	0.11（0.21）	0.458	0.654
t（Z）值	-1.632	-1.099			-0.199	-2.163			-0.038^a	-0.032^a
P值	0.114	0.281			0.844	0.037			0.970	0.742
组别	FFA（mmol/L）				HOMA-IR				HOMA-β
组别	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值
A组	0.50±0.20	0.52±0.23	-0.283	0.780	3.96±2.48	3.70±1.68	1.322	0.202	52.26±23.26	79.03±27.26	-3.256	0.005
B组	0.44±0.21	0.57±0.28	-1.534	0.141	4.26±2.65	4.08±2.14	0.746	0.467	53.93±29.07	86.88±54.95	-3.432	0.005
t（Z）值	-0.317	0.656			0.478	0.320			1.218	0.909
P值	0.753	0.516			0.645	0.753			0.234	0.380

组别	例数	FPG（mmol/L）				HbA_1c（%）				LDL-C（mmol/L）
组别	例数	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值
A组	34	8.20±1.19	7.29±1.17	2.295	0.031	7.92±0.75	7.22±0.61	2.941	0.008	2.48±0.77	2.40±0.71	0.151	0.201
B组	29	8.39±1.03	7.07±0.98	4.041	0.001	8.18±1.03	7.20±0.90	3.296	0.004	2.92±0.72	2.60±0.79	0.201	0.034
t（Z）值		1.163	-0.955			0.822	0.098			1.730	0.969
P值		0.252	0.346			0.416	0.922			0.092	0.339
组别	TC（mmol/L）				TG（mmol/L）				HDL-C（mmol/L）
组别	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值
A组	4.67±1.05	4.38±0.96	-1.749	0.096	1.78±1.02	1.55±0.97	0.644	0.527	1.16±0.32	1.18±0.21	-0.129	0.899
B组	4.83±0.92	4.36±0.98	0.255	0.001	1.85±1.16	1.60±0.85	0.787	0.441	1.17±0.21	1.24±0.24	-0.923	0.368
t（Z）值	0.482	0.319			0.325	0.182			0.355	0.957
P值	0.632	0.751			0.747	0.857			0.724	0.345
组别	UA（μmol/L）				2 hPG（mmol/L）				hs-CRP〔M（QR），mg/d〕
组别	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	Z值	P值
A组	360.92±29.11	327.00±21.85	1.661	0.123	11.60±1.70	9.72±1.65	3.979	0.001	0.12（0.27）	0.11（0.17）	0.541	0.594
B组	339.77±34.16	304.85±41.75	1.505	0.171	11.42±1.47	8.76±1.10	14.130	<0.001	0.11（0.18）	0.11（0.21）	0.458	0.654
t（Z）值	-1.632	-1.099			-0.199	-2.163			-0.038^a	-0.032^a
P值	0.114	0.281			0.844	0.037			0.970	0.742
组别	FFA（mmol/L）				HOMA-IR				HOMA-β
组别	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值	治疗前	治疗12周后	t_配对值	P值
A组	0.50±0.20	0.52±0.23	-0.283	0.780	3.96±2.48	3.70±1.68	1.322	0.202	52.26±23.26	79.03±27.26	-3.256	0.005
B组	0.44±0.21	0.57±0.28	-1.534	0.141	4.26±2.65	4.08±2.14	0.746	0.467	53.93±29.07	86.88±54.95	-3.432	0.005
t（Z）值	-0.317	0.656			0.478	0.320			1.218	0.909
P值	0.753	0.516			0.645	0.753			0.234	0.380

Effects of Music Therapy Assisted Anagliptin on Glycolipid Metabolism in Patients with Type 2 Diabetes

音乐辅助阿格列汀对2型糖尿病患者糖脂代谢的影响研究

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[1]	WANG Ying, YAN Yijun, LIU Lei, HU Yumin, ZHANG Yang, LIU Kai, JIANG Boren. Effects of Resistance Exercise Combined with Nutritional Intervention on Blood Glucose Stability in Elderly Patients with Type 2 Diabetes Mellitus with Sarcopenia [J]. Chinese General Practice, 2025, 28(21): 2604-2610.
[2]	MA Panpan, WANG Sijing, YOU Na, DING Dafa, LU Yibing. Efficacy and Safety of Danuglipron and Orforglipron in the Treatment of Type 2 Diabetes Mellitus: a Meta-analysis [J]. Chinese General Practice, 2025, 28(21): 2679-2685.
[3]	HUANG Zhijie, MAI Zhihua, WANG Haoxiang, HE Yuming, DENG Qiaoyan, DAI Ranran, ZHOU Zhiheng. Multimorbidity of Hypertension, Diabetes, and Dyslipidemia and Influencing Factors of Family Function among the Elderly [J]. Chinese General Practice, 2025, 28(16): 2001-2010.
[4]	ZHU Shengjie, DIAO Huaqiong, HANG Xiaoyi, SUN Wenjun. Network Meta-analysis of Different Traditional Chinese Medicine Injections for the Treatment of Posterior Circulatory Ischemic Vertigo [J]. Chinese General Practice, 2025, 28(14): 1795-1808.
[5]	LIU Caiping, ZHANG Yanhua, TANG Jianpin, WANG Chengpeng, XUE Fengfeng, WANG Huijuan, LI Chuanwei, ZHANG Guangya, LI Huafang. Efficacy and Safety of Long-acting Risperidone Microspheres in the Maintenance Treatment of Schizophrenia [J]. Chinese General Practice, 2025, 28(13): 1622-1627.
[6]	WANG Die, WU Bangyun, TAN Cunyao, SHEN Shihui, LI You, MENG Yue, WANG Dashan, HU Jin, WANG Ziyun, WANG Junhua. Association between Sleep Efficiency and Dyslipidemia among Adults Aged 40 to 65 [J]. Chinese General Practice, 2025, 28(13): 1601-1606.
[7]	FAN Haojie, LIU Lewei, XIA Lei, TIAN Yinghan, YANG Cheng, HAO Mingru, ZHAO Xin, SHEN Qingqing, MO Daming, GENG Feng, LIU Huanzhong. Correlation of Non-suicidal Self-injury with 25-Hydroxyvitamin D₃ and Blood Lipid Levels in Adolescents with Major Depressive Disorder [J]. Chinese General Practice, 2025, 28(05): 612-618.
[8]	YANG Hong, LIU Cheng, LIU Sen, SHAO Qiqi, YAO Yuanhao, FU Zhenyan. Association of Residual Cholesterol with Vulnerable Plaques in Non-culprit Lesions Progressing to Major Adverse Cardiovascular Events [J]. Chinese General Practice, 2025, 28(03): 299-304.
[9]	MA Huping, REN Rong, HOU Mei, YUAN Aiyun. Clinical Observation of the New Antiepileptic Drug Perampanel in the Treatment of Refractory Epilepsy in Children Aged 0-18 Years [J]. Chinese General Practice, 2025, 28(02): 250-256.
[10]	LI Yiguang, LIU Hejun, ZHAO Jinpeng, FENG Yan, XU Yinlan. Meta-analysis of the Effect of Carbohydrates on Cardiovascular Disease Risk Factors [J]. Chinese General Practice, 2024, 27(34): 4341-4349.
[11]	ZHENG Chuanlei, DING Ruicong, WANG Qi, GUO Yixing, LI Jian, HUANG Zhengchun, DONG Minghua, LUO Xiaoting, WU Qingfeng. Study on the Relationship between Dietary Patterns and Dyslipidemia among Residents Aged ≥35 Years: Based on the Gannan Chronic Disease Cohort Survey Data [J]. Chinese General Practice, 2024, 27(30): 3739-3745.
[12]	Beijing Hypertension Association, China Association of Gerontology and Geriatrics, Beijing Community Health Service Association, Beijing Community Health Promotion Association. Chinese Expert Consensus on Grassroots Prevention and Treatment of Hypertension Combined with Type 2 Diabetes Mellitus and Dyslipidemia in Adults 2024 [J]. Chinese General Practice, 2024, 27(28): 3453-3475.
[13]	YANG Can, LI Ning, LI Xuefei, ZHAO Li, XU Hao, SHI Qi, WANG Yongjun, LIANG Qianqian. Efficacy of Zang Bi Formula in Treating Arthritis and Its Pulmonary Complications in Rheumatoid Arthritis Interstitial Lung Disease Mice [J]. Chinese General Practice, 2024, 27(24): 3015-3022.
[14]	PANG Lan, LI Peifan, ZHU Xiaogang, YANG Zaihong, ZHENG Lei. Deep Transcranial Magnetic Stimulation Combined with Escitalopram Oxalate in the Treatment of Depression: a Randomized Controlled Trial [J]. Chinese General Practice, 2024, 27(17): 2098-2103.
[15]	LIU Wenjun, YAO Mi, JING Guanning, YAN Cunling, YAN Hui. Interpretation of Screening for Lipid Disorders in Children and Adolescents: U.S. Preventive Services Task Force Recommendation Statement [J]. Chinese General Practice, 2024, 27(15): 1796-1801.