Sleep problems are increasingly common in residents with the acceleration of pace of life. Studies have shown that sleep duration is associated with chronic diseases such as hypertension and diabetes, but there is a lack of research on its association with hyperuricemia.

To assess the association and its dose-response level between sleep duration and hyperuricemia.

Data stemmed from the 2019 surveillance of epidemiology and risk factors of chronic diseases in adult residents in Haidian District, Beijing, involving individuals aged 18-79 years old, with an experience of living in Haidian District at least six months. The information was obtained via a face-to-face questionnaire survey, including the following aspects: demographics (sex, age, education level, marital status, occupation) , lifestyle factors (smoking and drinking, physical activity level, sleep duration) , history of chronic diseases (hypertension and diabetes) , height, weight, blood pressure, laboratory indices (fasting blood glucose, serum uric acid, and serum creatinine) . A multivariable Logistic regression model was used to assess the association between sleep duration and the risk of hyperuricemia, whose dose-response relationship was analysed using restricted cubic spline regression.

A total of 5 380 people were enrolled, with an average age of (46.9±16.0) years and an average sleep duration of (7.24±1.16) hours. Univariate Logistic regression analysis showed that, compared with those with 7-9 hours of sleep duration, the risk of hyperuricemia increased in those with less than 7 hours of sleep duration and in those with greater than 9 hours of sleep duration 〔OR (95%CI) =1.30 (1.12, 1.51) ; OR (95%CI) =1.48 (1.15, 1.89) 〕. After adjusting for age, gender, education level, marital status, occupation, smoking, drinking, physical activity level, BMI, hypertension, diabetes, and serum creatinine, the risk of hyperuricemia still increased in those with less than 7 hours of sleep duration and in those with greater than 9 hours of sleep duration 〔OR (95%CI) =1.37 (1.17, 1.62) ; OR (95%CI) =1.39 (1.07, 1.81) 〕. Restricted cubic spline regression analysis showed that sleep duration had a U-shaped association with hyperuricemia (non-linear test, χ²=27.530, P<0.001) .

Too longer or shorter sleep duration was a factor responsible for increased risk of hyperuricemia among adults in Haidian District of Beijing.

随着社会节奏加快，居民睡眠问题十分普遍，有研究显示睡眠时间与高血压、糖尿病等慢性病相关，但其和高尿酸血症的关联研究较为缺乏。

探讨睡眠时间和高尿酸血症之间的关联，并评估其量效关系。

采用2019年北京市海淀区成人慢性病及其危险因素监测数据，以北京市海淀区18~79岁的常住居民（在海淀区居住6个月以上）为研究对象。收集研究对象的基本人口学信息（性别、年龄、文化程度、婚姻状况、职业）、个人生活方式（吸烟情况、饮酒情况、身体活动水平、睡眠时间）、慢性病患病情况（是否患高血压、糖尿病）、身高、体质量、血压、血糖、血尿酸、血肌酐，应用多因素Logistic回归模型分析探讨睡眠时间与高尿酸血症患病的关联，采用限制性立方样条回归分析睡眠时间与高尿酸血症患病风险的量效关系。

本研究共纳入5 380例居民，平均年龄（46.9±16.0）岁，平均睡眠时间（7.24±1.16）h。单因素Logistic回归分析结果显示，与睡眠时间7~9 h组相比，睡眠时间<7 h组和>9 h组患病风险增高〔OR_{<7 h}（95%CI）=1.30（1.12，1.51），OR_{>9 h}（95%CI）=1.48（1.15，1.89）〕。调整年龄、性别、文化程度、婚姻状况、职业、吸烟情况、饮酒情况、身体活动水平、BMI水平、高血压、糖尿病、血肌酐后，与睡眠时间7~9 h人群相比，睡眠时间<7 h和>9 h的人群高尿酸血症患病风险较高〔OR_{<7 h}（95%CI）=1.37（1.17，1.62），OR_{>9 h}（95%CI）=1.39（1.07，1.81）〕。限制性立方样条回归分析结果显示，睡眠时间与高尿酸血症患病的关联强度呈"U"型分布（非线性检验χ²=27.530，P<0.001）。

北京市海淀区成年人睡眠时间过长或过短均会增加高尿酸血症患病风险。