The Glymphatic System：a New
Exploration of Pathological Mechanism in Stroke

doi:10.12114/j.issn.1007-9572.2021.02.107

Abstract

Abstract:

The glymphatic system is a system that promotes the exchange and flow of cerebrospinal fluid (CSF) -interstitial fluid (ISF) to maintain the balance of CSF-ISF, and rid the neuropil of toxic proteinaceous metabolites with astroglial water channel aquaporin-4 as the mediator. Increasing evidence has shown that the glymphatic system is strongly related to the pathological changes and outcomes of stroke. Available studies have found that the glymphatic system partially affects post-stroke cerebrospinal fluid circulation and cerebral edema. Different types of strokes include acute ischemic stroke, subarachnoid hemorrhage and intracerebral hemorrhage also have pathological changes in the glymphatic system. This review summarizes the structure and function of the glymphatic system, and the latest developments in its impact on pathological changes of different types of strokes, providing a new direction for the prevention and treatment of stroke.

Key words: Stroke, Glymphatic system, Aquaporin 4, Review

摘要：

胶质淋巴系统是一个由星形胶质细胞上水通道蛋白4（AQP4）介导的促进脑脊液（CSF）-组织液（ISF）交换流动的系统，起到维持CSF-ISF平衡及清除脑内代谢废物等作用。越来越多的证据显示胶质淋巴系统与脑卒中病理改变及转归密切相关。目前研究发现胶质淋巴系统对脑卒中后CSF循环及脑水肿的发生有一定影响，且对急性缺血性脑卒中、蛛网膜下腔出血、脑出血等不同类型的脑卒中的病理改变也有影响。本文就胶质淋巴系统的结构、功能及其对不同类型脑卒中病理变化影响的研究进展进行综述，为脑卒中的防治提供参考。

关键词: 卒中, 脑胶质淋巴系统, 水通道蛋白质4, 综述

CLC Number:

R322.811

YI Ting, JIN Shuoguo, YIN Haiyan, GAO Ping, ZHU Tianmin.

The Glymphatic System：a New Exploration of Pathological Mechanism in Stroke [J]. Chinese General Practice, 2022, 25(09): 1136-1140.

易婷,金硕果,尹海燕等. 脑胶质淋巴系统——脑卒中病理机制的新探索[J]. 中国全科医学, 2022, 25(09): 1136-1140. DOI: 10.12114/j.issn.1007-9572.2021.02.107.

Figures/Tables 2

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